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Index > Protein center > FGG(Gene name) > Human
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  • FGG (Gene name),
  • Fibrinogen gamma chain (Protein name ),  FIBG_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (2)
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  • Gene name:
    FGG(PRO2061);
    Protein name:
    Fibrinogen gamma chain;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.
    Function:
    Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    453
    Sequence:
    50:
    MSWSLHPRNL | ILYFYALLFL | SSTCVAYVAT | RDNCCILDER | FGSYCPTTCG | 
    100:
    IADFLSTYQT | KVDKDLQSLE | DILHQVENKT | SEVKQLIKAI | QLTYNPDESS | 
    150:
    KPNMIDAATL | KSRKMLEEIM | KYEASILTHD | SSIRYLQEIY | NSNNQKIVNL | 
    200:
    KEKVAQLEAQ | CQEPCKDTVQ | IHDITGKDCQ | DIANKGAKQS | GLYFIKPLKA | 
    250:
    NQQFLVYCEI | DGSGNGWTVF | QKRLDGSVDF | KKNWIQYKEG | FGHLSPTGTT | 
    300:
    EFWLGNEKIH | LISTQSAIPY | ALRVELEDWN | GRTSTADYAM | FKVGPEADKY | 
    350:
    RLTYAYFAGG | DAGDAFDGFD | FGDDPSDKFF | TSHNGMQFST | WDNDNDKFEG | 
    400:
    NCAEQDGSGW | WMNKCHAGHL | NGVYYQGGTY | SKASTPNGYD | NGIIWATWKT | 
    450:
    RWYSMKKTTM | KIIPFNRLTI | GEGQQHHLGG | AKQVRPEHPA | ETEYDSLYPE | 
    453:
    DDL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    UniGene:
    String:
    MIM:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Fibrinogen gamma chain
    Cat.:
    E0067r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Fibrinogen gamma chain
    Cat.:
    E0067h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Fibrinogen gamma chain
    Cat.:
    E0067m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Fibrinogen gamma chain
    Cat.:
    E0067b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Fibrinogen gamma chain
    Cat.:
    E0067d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Fibrinogen gamma chain
    Cat.:
    U0067d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen gamma chain
    Cat.:
    U0067h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Fibrinogen gamma chain
    Cat.:
    U0067r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Fibrinogen gamma chain
    Cat.:
    U0067m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Fibrinogen gamma chain
    Cat.:
    U0067b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Fibrinogen gamma chain
    Cat.:
    P0067Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fibrinogen gamma chain
    Polyclonal Antibody for Human Fibrinogen gamma chain
    Cat.:
    P0067Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Fibrinogen gamma chain
    Polyclonal Antibody for Human Fibrinogen gamma chain
    Cat.:
    P0067Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Fibrinogen gamma chain
    Monoclonal Antibody for Human Fibrinogen gamma chain
    Monoclonal Antibody for Human Fibrinogen gamma chain
    Monoclonal Antibody for Human Fibrinogen gamma chain
    Monoclonal Antibody for Human Fibrinogen gamma chain
    Protein for Human Fibrinogen gamma chain
    Protein for Human Fibrinogen gamma chain
    Protein for Human Fibrinogen gamma chain
    Protein for Human Fibrinogen gamma chain
    Protein for Human Fibrinogen gamma chain

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of a complementary deoxyribonucleic acid coding for the gamma chain of human fibrinogen."
      Chung D.W. , Chan W.-Y. , Davie E.W.
      Biochemistry22:3250-3256(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "Nucleotide sequence of the gene for the gamma chain of human fibrinogen."
      Rixon M.W. , Chung D.W. , Davie E.W.
      Biochemistry24:2077-2086(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS GAMMA-A AND GAMMA-B)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS GAMMA-A AND GAMMA-B)
      tissue: Liver.
    4. 4.
      "Functional prediction of the coding sequences of 33 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C. , Yu Y. , Zhang S. , Wei H. , Zhou G. , Bi J. , Zhang Y. , Liu M. , He F.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA-A)
      tissue: Fetal liver.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA-A)
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-140 AND ARG-191
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA-A)
      tissue: Skeletal muscle.
    9. 9.
      "Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants."
      Henschen A. , Lottspeich F. , Southan C. , Topfer-Petersen E.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-437
    10. 10.
      "Evidence for the selective association of a subpopulation of GPIIb-IIIa with the actin cytoskeletons of thrombin-activated platelets."
      Bertagnolli M.E. , Beckerle M.C.
      J. Cell Biol.121:1329-1342(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
      tissue: Platelet.
    11. 11.
      "Polymorphism of the human gamma chain fibrinogen gene."
      Marchetti L. , Zanelli T. , Malcovati M. , Tenchini M.L.
      DNA Seq.1:419-422(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-286
      tissue: Liver.
    12. 12.
      "Isolation and characterisation of cDNA clones for the A alpha- and gamma-chains of human fibrinogen."
      Imam A.M.A. , Eaton M.A.W. , Williamson R. , Humphries S.
      Nucleic Acids Res.11:7427-7434(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 209-270
    13. 13.
      "Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen."
      Fornace A.J. Jr. , Cummings D.E. , Comeau C.M. , Kant J.A. , Crabtree G.R.
      J. Biol. Chem.259:12826-12830(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 285-437 (ISOFORMS GAMMA-A AND GAMMA-B)
    14. 14.
      "Abnormal polymerization and normal binding of plasminogen and t-PA in three new dysfibrinogenaemias: Barcelona III and IV (gamma Arg 275-->His) and Villajoyosa (gamma Arg 275-->Cys)."
      Borrell M. , Gari M. , Coll I. , Vallve C. , Tirado I. , Soria J.M. , Sala N. , Munoz C. , Oliver A. , Garcia A.
      Blood Coagul. Fibrinolysis6:198-206(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 291-310;VARIANTS BARCELONA-3/BARCELONA-4 HIS-301 AND VILLAJOYOSA CYS-301
      tissue: Blood.
    15. 15.
      "Carboxy-terminal amino acid sequence of a human fibrinogen gamma-chain variant (gamma')."
      Wolfenstein-Todel C. , Mosesson M.W.
      Biochemistry20:6146-6149(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 411-453 (ISOFORM GAMMA-B)
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;DISULFIDE BONDS
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    18. 18.
      "Disulfide bridges in NH2-terminal part of human fibrinogen."
      Blombaeck B. , Hessel B. , Hogg D.
      Thromb. Res.8:639-658(1976) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    19. 19.
      "Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation."
      Hoeprich P.D. , Doolittle R.F.
      Biochemistry22:2049-2055(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: QUATERNARY STRUCTURE;DISULFIDE BONDS
    20. 20.
      "Recombinant human fibrinogen and sulfation of the gamma' chain."
      Farrel D.H. , Mulvihill E.R. , Huang S. , Chung D.W. , Davie E.W.
      Biochemistry30:9414-9420(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION
    21. 21.
      "The amino acid sequence in fibrin responsible for high affinity thrombin binding."
      Meh D.A. , Siebenlist K.R. , Brennan S.O. , Holyst T. , Mosesson M.W.
      Thromb. Haemost.85:470-474(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SULFATION AT TYR-444 AND TYR-448
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;ELECTRON MICROSCOPY;POLYMERIZATION;LIGANDS
    23. 23.
      "Localization of a fibrin gamma-chain polymerization site within segment Thr-374 to Glu-396 of human fibrinogen."
      Horwitz B.H. , Varadi A. , Scheraga H.A.
      Proc. Natl. Acad. Sci. U.S.A.81:5980-5984(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMERIZATION SITE
    24. 24.
      "Localization of a fibrin polymerization site."
      Olexa S.A. , Budzynski A.Z.
      J. Biol. Chem.256:3544-3549(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMERIZATION SITE
    25. 25.
      "Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the gamma chain."
      Kloczewiak M. , Timmons S. , Lukas T.J. , Hawiger J.
      Biochemistry23:1767-1774(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PLATELET AGGREGATION SITE
    26. 26.
      "Evidence that three adhesive proteins interact with a common recognition site on activated platelets."
      Plow E.F. , Srouji A.H. , Meyer D. , Marguerie G. , Ginsberg M.H.
      J. Biol. Chem.259:5388-5391(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PLATELET AGGREGATION SITE
    27. 27.
      "Localization of a fibrinogen calcium binding site between gamma-subunit positions 311 and 336 by terbium fluorescence."
      Dang C.V. , Ebert R.F. , Bell W.R.
      J. Biol. Chem.260:9713-9719(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CALCIUM-BINDING SITE
    28. 28.
      "Human plasma fibrinogen heterogeneity: evidence for an extended carboxyl-terminal sequence in a normal gamma chain variant (gamma')."
      Wolfenstein-Todel C. , Mosesson M.W.
      Proc. Natl. Acad. Sci. U.S.A.77:5069-5073(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMATOGRAPHIC COMPARISON OF GAMMA-A AND GAMMA-B CHAINS
    29. 29.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
      tissue: Plasma.
    30. 30.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
      tissue: Plasma.
    31. 31.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
      tissue: Platelet.
    32. 32.
      "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
      Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
      Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
      tissue: Milk.
    33. 33.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-78
      tissue: Liver.
    34. 34.
      "A strategy for precise and large scale identification of core fucosylated glycoproteins."
      Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
      Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-78
    35. 35.
      "A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule."
      Kirschbaum N.E. , Budzynski A.Z.
      J. Biol. Chem.265:13669-13676(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY HEMENTIN AND PLASMIN
    36. 36.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    37. 37.
      "Crystal structure of a 30 kDa C-terminal fragment from the gamma chain of human fibrinogen."
      Yee V.C. , Pratt K.P. , Cote H.C.F. , le Trong I. , Chung D.W. , Davie E.W. , Stenkamp R.E. , Teller D.C.
      Structure5:125-138(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 169-437
    38. 38.
      "The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro."
      Pratt K.P. , Cote H.C.F. , Chung D.W. , Stenkamp R.E. , Davie E.W.
      Proc. Natl. Acad. Sci. U.S.A.94:7176-7181(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 169-437
    39. 39.
      "Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin."
      Spraggon G. , Everse S.J. , Doolittle R.F.
      Nature389:455-462(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 114-432
    40. 40.
      "Crystal structure of fragment double-D from human fibrin with two different bound ligands."
      Everse S.J. , Spraggon G. , Veerapandian L. , Riley M. , Doolittle R.F.
      Biochemistry37:8637-8642(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 114-432
    41. 41.
      "Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide."
      Everse S.J. , Spraggon G. , Veerapandian L. , Doolittle R.F.
      Biochemistry38:2941-2946(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 114-432
    42. 42.
      "A gamma methionine-310 to threonine substitution and consequent N-glycosylation at gamma asparagine-308 identified in a congenital dysfibrinogenemia associated with posttraumatic bleeding, fibrinogen Asahi."
      Yamazumi K. , Shimura K. , Terukina S. , Takahashi N. , Matsuda M.
      J. Clin. Invest.83:1590-1597(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASAHI THR-336
    43. 43.
      "Gene analyses of abnormal fibrinogens with a mutation in the gamma chain."
      Mimuro J. , Muramatsu S. , Maekawa H. , Sakata Y. , Kaneko M. , Yoshitake S. , Okuma M. , Ito Y. , Takeda Y. , Matsuda M.
      Int. J. Hematol.56:129-134(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OSAKA-2 CYS-301; KYOTO-1 LYS-334; ASAHI THR-336 AND KYOTO-3 TYR-356
    44. 44.
      "Fibrinogen Baltimore I: polymerization defect associated with a gamma 292Gly-->Val (GGC-->GTC) mutation."
      Bantia S. , Mane S.M. , Bell W.R. , Dang C.V.
      Blood76:2279-2283(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BALTIMORE-1 VAL-318
    45. 45.
      "Polymerization defect of fibrinogen Baltimore III due to a gamma Asn308-->Ile mutation."
      Bantia S. , Bell W.R. , Dang C.V.
      Blood75:1659-1663(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BALTIMORE-3 ILE-334
    46. 46.
      "Fibrinogen Bern I: substitution gamma 337 Asn-->Lys is responsible for defective fibrin monomer polymerization."
      Steinmann C. , Reber P. , Jungo M. , Laemmle B. , Heinemann G. , Wermuth B. , Furlan M.
      Blood82:2104-2108(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BERN-1 LYS-363
    47. 47.
      "Characterization of an apparently lower molecular weight gamma-chain variant in fibrinogen Kyoto I. The replacement of gamma-asparagine 308 by lysine which causes accelerated cleavage of fragment D1 by plasmin and the generation of a new plasmin cleavage site."
      Yoshida N. , Terukina S. , Okuma M. , Moroi M. , Aoki N. , Matsuda M.
      J. Biol. Chem.263:13848-13856(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT KYOTO-1 LYS-334
    48. 48.
      "Fibrinogen Kyoto III: a congenital dysfibrinogen with a gamma aspartic acid-330 to tyrosine substitution manifesting impaired fibrin monomer polymerization."
      Terukina S. , Yamazumi K. , Okamoto K. , Yamashita H. , Ito Y. , Matsuda M.
      Blood74:2681-2687(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT KYOTO-3 TYR-356
    49. 49.
      "Characterization of fibrinogen Milano I: amino acid exchange gamma 330 Asp-->Val impairs fibrin polymerization."
      Reber P. , Furlan M. , Rupp C. , Kehl M. , Henschen A. , Mannucci P.M. , Beck E.A.
      Blood67:1751-1756(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MILANO-1 VAL-356
    50. 50.
      "Fibrinogen Milano V: a congenital dysfibrinogenaemia with a gamma 275 Arg-->Cys substitution."
      Steinmann C. , Boegli C. , Jungo M. , Laemmle B. , Heinemann G. , Wermuth B. , Redaelli R. , Baudo F. , Furlan M.
      Blood Coagul. Fibrinolysis5:463-471(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MILANO-5 CYS-301
    51. 51.
      "A new substitution, gamma 358 Ser-->Cys, in fibrinogen Milano VII causes defective fibrin polymerization."
      Steinmann C. , Boegli C. , Jungo M. , Laemmle B. , Heinemann G. , Wermuth B. , Redaelli R. , Baudo F. , Furlan M.
      Blood84:1874-1880(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MILANO-7 CYS-384
    52. 52.
      "Fibrinogen Nagoya, a replacement of glutamine-329 by arginine in the gamma-chain that impairs the polymerization of fibrin monomer."
      Miyata T. , Furukawa K. , Iwanaga S. , Takamatsu J. , Saito H.
      J. Biochem.105:10-14(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NAGOYA-1 ARG-355
    53. 53.
      "Substitution of gamma Arg-275 by Cys in an abnormal fibrinogen, 'fibrinogen Osaka II'. Evidence for a unique solitary cystine structure at the mutation site."
      Terukina S. , Matsuda M. , Hirata H. , Takeda Y. , Miyata T. , Takao T. , Shimonishi Y.
      J. Biol. Chem.263:13579-13587(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OSAKA-2 CYS-301
    54. 54.
      "Heterozygous abnormal fibrinogen Osaka III with the replacement of gamma arginine-275 by histidine has an apparently higher molecular weight gamma-chain variant."
      Yoshida N. , Imoka S. , Hirata H. , Matsuda M. , Asakura S.
      Thromb. Haemost.68:534-538(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OSAKA-3 HIS-301
    55. 55.
      "Characterization of an abnormal fibrinogen Osaka V with the replacement of gamma-arginine 375 by glycine. The lack of high affinity calcium binding to D-domains and the lack of protective effect of calcium on fibrinolysis."
      Yoshida N. , Hirata H. , Morigami Y. , Imaoka S. , Matsuda M. , Yamazumi K. , Asakura S.
      J. Biol. Chem.267:2753-2759(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OSAKA-5 GLY-401
    56. 56.
      "Paris I dysfibrinogenemia: a point mutation in intron 8 results in insertion of a 15 amino acid sequence in the fibrinogen gamma-chain."
      Rosenberg J.B. , Newman P.J. , Mosesson M.W. , Guillin M.-C. , Amrani D.L.
      Thromb. Haemost.69:217-220(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT PARIS-1 GLY-377 DELINS VAL-MET-CYS-GLY-GLU-ALA-LEU-PRO-MET-LEU-LYS-ASP-PRO-CYS-TYR-SER
    57. 57.
      "An apparently higher molecular weight gamma-chain variant in a new congenital abnormal fibrinogen Tochigi characterized by the replacement of gamma arginine-275 by cysteine."
      Yoshida N. , Ota K. , Moroi M. , Matsuda M.
      Blood71:480-487(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TOCHIGI CYS-301
    58. 58.
      "A congenitally abnormal fibrinogen (Vlissingen) with a 6-base deletion in the gamma-chain gene, causing defective calcium binding and impaired fibrin polymerization."
      Koopman J. , Haverkate F. , Briet E. , Lord S.T.
      J. Biol. Chem.266:13456-13461(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VLISSINGEN 345-ASN-ASP-346 DEL
    59. 59.
      "Three abnormal fibrinogen variants with the same amino acid substitution (gamma 275 Arg-->His): fibrinogens Bergamo II, Essen and Perugia."
      Reber P. , Furlan M. , Henschen A. , Kaudewitz H. , Barbui T. , Hilgard P. , Nenci G.G. , Berrettini M. , Beck E.A.
      Thromb. Haemost.56:401-406(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BERGAMO-2/ESSEN/HAIFA/PERUGIA HIS-301
    60. 60.
      "Normal plasmic cleavage of the gamma-chain variant of 'fibrinogen Saga' with an Arg-275 to His substitution."
      Yamazumi K. , Terukina S. , Onohara S. , Matsuda M.
      Thromb. Haemost.60:476-480(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SAGA HIS-301
    61. 61.
      "Fibrinogen Milano XII: a dysfunctional variant containing 2 amino acid substitutions, A-alpha R16C and gamma G165R."
      Bolliger-Stucki B. , Lord S.T. , Furlan M.
      Blood98:351-357(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MILANO-12 ARG-191
    62. 62.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ARG-191 AND VAL-410
    63. 63.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    64. 64.
      "Fibrinogen Hillsborough: a novel gamma-gly309asp dysfibrinogen with impaired clotting."
      Mullin J.L. , Brennan S.O. , Ganly P.S. , George P.M.
      Blood99:3597-3601(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HILLSBOROUGH ASP-335
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