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Index > Protein center > HAVCR1(Gene name) > Human
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  • HAVCR1 (Gene name),
  • Hepatitis A virus cellular receptor 1 (Protein name ),  HAVR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (6)
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  • Gene name:
    HAVCR1(KIM1;TIM1;TIMD1);
    Protein name:
    Hepatitis A virus cellular receptor 1(HAVcr-1);
    Alternative:
    T-cell immunoglobulin and mucin domain-containing protein 1(TIMD-1);Kidney injury molecule 1(KIM-1);TIM-1(TIM);T-cell membrane protein 1(TIM);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    359
    Sequence:
    50:
    MHPQVVILSL | ILHLADSVAG | SVKVGGEAGP | SVTLPCHYSG | AVTSMCWNRG | 
    100:
    SCSLFTCQNG | IVWTNGTHVT | YRKDTRYKLL | GDLSRRDVSL | TIENTAVSDS | 
    150:
    GVYCCRVEHR | GWFNDMKITV | SLEIVPPKVT | TTPIVTTVPT | VTTVRTSTTV | 
    200:
    PTTTTVPTTT | VPTTMSIPTT | TTVLTTMTVS | TTTSVPTTTS | IPTTTSVPVT | 
    250:
    TTVSTFVPPM | PLPRQNHEPV | ATSPSSPQPA | ETHPTTLQGA | IRREPTSSPL | 
    300:
    YSYTTDGNDT | VTESSDGLWN | NNQTQLFLEH | SLLTANTTKG | IYAGVCISVL | 
    350:
    VLLALLGVII | AKKYFFKKEV | QQLSVSFSSL | QIKALQNAVE | KEVQAEDNIY | 
    359:
    IENSLYATD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    UniGene:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human HAVcr-1
    Cat.:
    E0785m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human HAVcr-1
    Cat.:
    E0785h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HAVcr-1
    Cat.:
    E0785r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HAVcr-1
    Cat.:
    U0785h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HAVcr-1
    Cat.:
    U0785m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HAVcr-1
    Cat.:
    U0785r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human HAVcr-1
    Cat.:
    P0785Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HAVcr-1
    Cat.:
    P0785Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HAVcr-1
    Cat.:
    P0785Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HAVcr-1
    Monoclonal Antibody for Human HAVcr-1
    Monoclonal Antibody for Human HAVcr-1
    Protein for Human HAVcr-1
    Protein for Human HAVcr-1
    Protein for Human HAVcr-1
    Cat.:
    R0785m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.6%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤6.9%

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.3%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.8%

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤4.5%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.9%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    95

    92-98

    Plasma

    89

    86-93

    Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    104

    94-110

    Plasma

    96

    89-105

     

     

     

     

    Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery  Range (%)

    Serum

    102

    95-114

    Plasma

    96

    93-99

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    89-93%

    89-101%

    86-99%

    93-102%

    EDTA plasma(n=5)

    92-104%

    88-101%

    82-93%

    86-91%

    heparin plasma(n=5)

    86-98%

     

    84-95%

    83-92%

    90-103%

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

    Sample               

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    89-103%

    86-101%

    83-99%

    97-110%

    EDTA plasma(n=5)

    97-108%

    88-101%

    79-102%

    89-99%

    heparin plasma(n=5)

    86-98%

     

    86-99%

    94-108%

    90-103%

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    89-101%

    90-105%

    93-97%

    93-107%

    EDTA plasma(n=5)

    95-110%

    89-97%

    94-110%

    88-99%

    heparin plasma(n=5)

    86-99%

     

    88-96%

    99-114%

    92-105%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor."
      Feigelstock D. , Thompson P. , Mattoo P. , Zhang Y. , Kaplan G.G.
      J. Virol.72:6621-6628(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION AS A HAV RECEPTOR;TISSUE SPECIFICITY
      tissue: Liver.
    2. 2.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS
      tissue: Kidney.
    4. 5.
      "Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions."
      Tami C. , Silberstein E. , Manangeeswaran M. , Freeman G.J. , Umetsu S.E. , DeKruyff R.H. , Umetsu D.T. , Kaplan G.G.
      J. Virol.81:3437-3446(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IMMUNOGLUBULIN A
    5. 6.
      "Tubular kidney injury molecule-1 (KIM-1) in human renal disease."
      van Timmeren M.M. , van den Heuvel M.C. , Bailly V. , Bakker S.J. , van Goor H. , Stegeman C.A.
      J. Pathol.212:209-217(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    7. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-THR-THR-THR-VAL-PRO-157 INS AND THR-195 DEL
    8. 9.
      Umetsu D.T.
      Submitted (2005-09) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-THR-THR-VAL-PRO-157 INS
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