HDAC4 ELISA Kit for Human(Homo sapiens) | EIAab.comHDAC4 ELISA Kit for Human(Homo sapiens) | EIAab.com

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HDAC4 (Gene name),

Histone deacetylase 4 (Protein name ), HDAC4_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

HDAC4(KIAA0288);

Protein name:

Histone deacetylase 4(HD4);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with HDAC7 (By similarity). Homodimer. Homodimerization via its N-terminal domain. Interacts with MEF2C, AHRR, and NR2C1. Interacts with a 14-3-3 chaperone protein in a phosphorylation dependent manner. Interacts with BTBD14B (By similarity). Interacts with KDM5B. Interacts with MYOCD (By similarity). Interacts with MORC2.

Function:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Subcellular Location:

Nucleus Cytoplasm Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Protein Attributes:

Sequence length:

1084

Sequence:

50:

MSSQSHPDGL | SGRDQPVELL | NPARVNHMPS | TVDVATALPL | QVAPSAVPMD |

100:

LRLDHQFSLP | VAEPALREQQ | LQQELLALKQ | KQQIQRQILI | AEFQRQHEQL |

150:

SRQHEAQLHE | HIKQQQEMLA | MKHQQELLEH | QRKLERHRQE | QELEKQHREQ |

200:

KLQQLKNKEK | GKESAVASTE | VKMKLQEFVL | NKKKALAHRN | LNHCISSDPR |

250:

YWYGKTQHSS | LDQSSPPQSG | VSTSYNHPVL | GMYDAKDDFP | LRKTASEPNL |

300:

KLRSRLKQKV | AERRSSPLLR | RKDGPVVTAL | KKRPLDVTDS | ACSSAPGSGP |

350:

SSPNNSSGSV | SAENGIAPAV | PSIPAETSLA | HRLVAREGSA | APLPLYTSPS |

400:

LPNITLGLPA | TGPSAGTAGQ | QDAERLTLPA | LQQRLSLFPG | THLTPYLSTS |

450:

PLERDGGAAH | SPLLQHMVLL | EQPPAQAPLV | TGLGALPLHA | QSLVGADRVS |

500:

PSIHKLRQHR | PLGRTQSAPL | PQNAQALQHL | VIQQQHQQFL | EKHKQQFQQQ |

550:

QLQMNKIIPK | PSEPARQPES | HPEETEEELR | EHQALLDEPY | LDRLPGQKEA |

600:

HAQAGVQVKQ | EPIESDEEEA | EPPREVEPGQ | RQPSEQELLF | RQQALLLEQQ |

650:

RIHQLRNYQA | SMEAAGIPVS | FGGHRPLSRA | QSSPASATFP | VSVQEPPTKP |

700:

RFTTGLVYDT | LMLKHQCTCG | SSSSHPEHAG | RIQSIWSRLQ | ETGLRGKCEC |

750:

IRGRKATLEE | LQTVHSEAHT | LLYGTNPLNR | QKLDSKKLLG | SLASVFVRLP |

800:

CGGVGVDSDT | IWNEVHSAGA | ARLAVGCVVE | LVFKVATGEL | KNGFAVVRPP |

850:

GHHAEESTPM | GFCYFNSVAV | AAKLLQQRLS | VSKILIVDWD | VHHGNGTQQA |

900:

FYSDPSVLYM | SLHRYDDGNF | FPGSGAPDEV | GTGPGVGFNV | NMAFTGGLDP |

950:

PMGDAEYLAA | FRTVVMPIAS | EFAPDVVLVS | SGFDAVEGHP | TPLGGYNLSA |

1000:

RCFGYLTKQL | MGLAGGRIVL | ALEGGHDLTA | ICDASEACVS | ALLGNELDPL |

1050:

PEKVLQQRPN | ANAVRSMEKV | MEIHSKYWRC | LQRTTSTAGR | SLIEAQTCEN |

1084:

EEAETVTAMA | SLSVGVKPAE | KRPDEEPMEE | EPPL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000264606

SMR:

Pfam:

UniGene:

KEGG:

String:

MIM:

Uniprot:

FOR

ELISA Kit for Human HD4

ELISA Kit for Human HD4

ELISA Kit for Human HD4

ELISA Kit for Human HD4

CLIA Kit for Human HD4

CLIA Kit for Human HD4

CLIA Kit for Human HD4

CLIA Kit for Human HD4

Polyclonal Antibody for Human HD4

Polyclonal Antibody for Human HD4

Polyclonal Antibody for Human HD4

Polyclonal Antibody for Human HD4

Monoclonal Antibody for Human HD4

Monoclonal Antibody for Human HD4

Monoclonal Antibody for Human HD4

Monoclonal Antibody for Human HD4

Protein for Human HD4

Protein for Human HD4

Protein for Human HD4

Protein for Human HD4

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Three proteins define a class of human histone deacetylases related to yeast Hda1p."
Grozinger C.M. , Hassig C.A. , Schreiber S.L.
Proc. Natl. Acad. Sci. U.S.A.96:4868-4873(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Leukemia.
2.

"Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins."
Ohara O. , Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Nomura N.
DNA Res.4:53-59(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

Ohara O. , Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Nomura N.
Submitted (1999-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO N-TERMINUS
4.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
7.

"HDAC4 deacetylase associates with and represses the MEF2 transcription factor."
Miska E.A. , Karlsson C. , Langley E. , Nielsen S.J. , Pines J. , Kouzarides T.
EMBO J.18:5099-5107(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH MEF2A
8.

"HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor."
Wang A.H. , Bertos N.R. , Vezmar M. , Pelletier N. , Crosato M. , Heng H.H. , Th'ng J. , Han J. , Yang X.-J.
Mol. Cell. Biol.19:7816-7827(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MEF2C AND MEF2D;MUTAGENESIS OF HIS-803
9.

"Regulation of histone deacetylase 4 by binding of 14-3-3 proteins."
Wang A.H. , Kruhlak M.J. , Wu J. , Bertos N.R. , Vezmar M. , Posner B.I. , Bazett-Jones D.P. , Yang X.-J.
Mol. Cell. Biol.20:6904-6912(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-246; SER-467 AND SER-632;MUTAGENESIS OF SER-246; SER-467 AND SER-632
10.

"The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking."
Zhao X. , Ito A. , Kane C.D. , Liao T.-S. , Bolger T.A. , Lemrow S.M. , Means A.R. , Yao T.-P.
J. Biol. Chem.276:35042-35048(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION;MUTAGENESIS OF SER-467 AND SER-632
11.

"Identification of a signal-responsive nuclear export sequence in class II histone deacetylases."
McKinsey T.A. , Zhang C.-L. , Olson E.N.
Mol. Cell. Biol.21:6312-6321(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEAR EXPORT SIGNAL;MUTAGENESIS OF VAL-1056 AND LEU-1062
12.

"The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases."
Franco P.J. , Farooqui M. , Seto E. , Wei L.-N.
Mol. Endocrinol.15:1318-1328(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR2C1
13.

"The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase."
Kirsh O. , Seeler J.-S. , Pichler A. , Gast A. , Mueller S. , Miska E. , Mathieu M. , Harel-Bellan A. , Kouzarides T. , Melchior F. , Dejean A.
EMBO J.21:2682-2691(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HOMODIMERIZATION;SUMOYLATION AT LYS-559;MUTAGENESIS OF LYS-559
14.

"Breast cancer associated transcriptional repressor PLU-1/JARID1B interacts directly with histone deacetylases."
Barrett A. , Santangelo S. , Tan K. , Catchpole S. , Roberts K. , Spencer-Dene B. , Hall D. , Scibetta A. , Burchell J. , Verdin E. , Freemont P. , Taylor-Papadimitriou J.
Int. J. Cancer121:265-275(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KDM5B
15.

"Nuclear calcium/calmodulin-dependent protein kinase IIdelta preferentially transmits signals to histone deacetylase 4 in cardiac cells."
Little G.H. , Bai Y. , Williams T. , Poizat C.
J. Biol. Chem.282:7219-7231(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMK2D
16.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-632 AND SER-633;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-350;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
18.

"Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems."
Williams S.R. , Aldred M.A. , Der Kaloustian V.M. , Halal F. , Gowans G. , McLeod D.R. , Zondag S. , Toriello H.V. , Magenis R.E. , Elsea S.H.
Am. J. Hum. Genet.87:219-228(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BDMR
19.

"Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX."
Shao Y. , Li Y. , Zhang J. , Liu D. , Liu F. , Zhao Y. , Shen T. , Li F.
Nucleic Acids Res.38:2813-2824(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MORC2
20.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
Kang H.J. , Lee M.H. , Kang H.L. , Kim S.H. , Ahn J.R. , Na H. , Na T.Y. , Kim Y.N. , Seong J.K. , Lee M.O.
Cancer Res.74:1484-1494(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EP300
23.

"Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock."
Xu C. , Jin J. , Bian C. , Lam R. , Tian R. , Weist R. , You L. , Nie J. , Bochkarev A. , Tempel W. , Tan C.S. , Wasney G.A. , Vedadi M. , Gish G.D. , Arrowsmith C.H. , Pawson T. , Yang X.J. , Min J.
Sci. Signal.5:RA39-RA39(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) OF 343-359 IN COMPLEX WITH ANKRA2;PHOSPHORYLATION AT SER-350
24.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-727

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