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Index > Protein center > HMGB1(Gene name) > Human
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  • HMGB1 (Gene name),
  • High mobility group protein B1 (Protein name ),  HMGB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    HMGB1(HMG1);
    Protein name:
    High mobility group protein B1;
    Alternative:
    High mobility group protein 1(HMG-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2.
    Function:
    DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells.
    Subcellular Location:
    Nucleus Chromosome
    Protein Attributes:
    Sequence length:
    215
    Sequence:
    50:
    MGKGDPKKPR | GKMSSYAFFV | QTCREEHKKK | HPDASVNFSE | FSKKCSERWK | 
    100:
    TMSAKEKGKF | EDMAKADKAR | YEREMKTYIP | PKGETKKKFK | DPNAPKRPPS | 
    150:
    AFFLFCSEYR | PKIKGEHPGL | SIGDVAKKLG | EMWNNTAADD | KQPYEKKAAK | 
    200:
    LKEKYEKDIA | AYRAKGKPDA | AKKGVVKAEK | SKKKKEEEED | EEDEEDEEEE | 
    215:
    EDEEDEDEEE | DDDDE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    KEGG:
    UniGene:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human High mobility group protein B1
    MSDS:
    Please sign in first.
    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399p
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human High mobility group protein B1
    Cat.:
    E0399b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human High mobility group protein B1
    Cat.:
    U0399m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human High mobility group protein B1
    Polyclonal Antibody for Human High mobility group protein B1
    Cat.:
    P0399Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human High mobility group protein B1
    Cat.:
    P0399Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human High mobility group protein B1
    Polyclonal Antibody for Human High mobility group protein B1
    Polyclonal Antibody for Human High mobility group protein B1
    Cat.:
    P0399Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Monoclonal Antibody for Human High mobility group protein B1
    Protein for Human High mobility group protein B1
    Cat.:
    R0399b
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1
    Cat.:
    R0399d
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1
    Cat.:
    R0399m
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1
    Cat.:
    R0399p
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1
    Cat.:
    R0399r
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1
    Cat.:
    R0399h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human High mobility group protein B1

    R&D Technical Data
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    12% SDS-PAGE analysis

              12% SDS-PAGE analysis

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1."
      Wen L. , Huang J.K. , Johnson B.H. , Reeck G.R.
      Nucleic Acids Res.17:1197-1214(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13."
      Ferrari S. , Finelli P. , Rocchi M. , Bianchi M.E.
      Genomics35:367-371(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa."
      Xiang Y.-Y. , Wang D.-Y. , Tanaka M. , Suzuki M. , Kiyokawa E. , Igarashi H. , Niato Y. , Shen Q. , Sugimura H.
      Int. J. Cancer74:1-6(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS ARG-11; GLU-149 AND GLY-190
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      He F.T. , Yang Z.H. , Ji Q. , Li R. , Peng J. , Jiang Y. , Zhong X.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Cerebellum.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Small intestine.
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    10. 10.
      SeattleSNPs variation discovery resource
      Submitted (2007-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT GLN-156
    11. 11.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Cervix.
      tissue: Testis.
    14. 14.
      "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2."
      Rasmussen R.K. , Ji H. , Eddes J.S. , Moritz R.L. , Reid G.E. , Simpson R.J. , Dorow D.S.
      Electrophoresis18:588-598(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 58-65 AND 113-127
      tissue: Mammary carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-100;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells."
      Tan F. , Lu L. , Cai Y. , Wang J. , Xie Y. , Wang L. , Gong Y. , Xu B.-E. , Wu J. , Luo Y. , Qiang B. , Yuan J. , Sun X. , Peng X.
      Proteomics8:2885-2896(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-112
      tissue: Cervix carcinoma.
    17. 17.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-30;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION
    22. 22.
      "Solution structure of the tandem HMG box domain from human high mobility group protein B1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2008-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-166
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