Heat shock 70 kDa protein 1A/1B (Protein name
), HSP71_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Predicted Eptitope
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Vaild Sequence
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Gene name:
HSPA1A(HSPA1;HSX70);
Protein name:
Heat shock 70 kDa protein 1A/1B;
Alternative:
Heat shock 70 kDa protein 1/2(HSP70-1/HSP70-2;HSP70.1/HSP70.2);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of a complex composed at least of CATSPER1, CATSPERB, CATSPERG and HSPA1B (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with TSC2. Interacts with IRAK1BP1. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed. Interacts with DNAJC7. Interacts with CHCHD3.
Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
Subcellular Location:
Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HSPA1A AND HSPA1B);VARIANTS ASP-110 AND SER-499
4.
"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region." Shiina S.
,
Tamiya G.
,
Oka A.
,
Inoko H.
Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HSPA1A AND HSPA1B)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
NIEHS SNPs program
Submitted (2006-02) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-95; ASP-110; VAL-467 AND SER-499
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ASP-110
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36 AND 360-424
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22 AND 617-641
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Cited for: PROTEIN SEQUENCE OF 4-49; 57-71; 77-155; 160-187; 221-247; 273-311; 326-342; 349-357; 362-416; 424-447; 459-469; 510-517; 540-550; 574-595 AND 598-641;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PROTEIN SEQUENCE OF 37-49; 57-71; 78-88; 113-126; 160-187; 221-247; 302-311; 329-342; 349-357; 362-384; 540-550 AND 574-589;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: PROTEIN SEQUENCE OF 551-567;METHYLATION AT LYS-561;MUTAGENESIS OF LYS-561;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: INTERACTION WITH TSC2;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: INTERACTION WITH PPP5C;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: INTERACTION WITH IRAK1BP1;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: IDENTIFICATION IN A MRNP GRANULE COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-108; LYS-246 AND LYS-348;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631; SER-633 AND THR-636;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: METHYLATION AT LYS-561;MUTAGENESIS OF LYS-561;INTERACTION WITH METTL21A
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Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-382 IN COMPLEX WITH ADP;ATP-BINDING
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Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 389-641 IN COMPLEX WITH ATP ANALOG;ATP-BINDING
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Cited for: X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 1-387 IN COMPLEX WITH ADP;ATP-BINDING
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Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-388 IN COMPLEX WITH BAG5
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Cited for: X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 1-388;ATP-BINDING;MUTAGENESIS OF ASP-10 AND ASP-199