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Index > Protein center > IHH(Gene name) > Human
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  • IHH (Gene name),
  • Indian hedgehog protein (Protein name ),  IHH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    IHH;
    Protein name:
    Indian hedgehog protein(IHH);
    Alternative:
    HHG-2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
    Subcellular Location:
    Indian hedgehog protein C-product Secreted extracellular space The C-terminal peptide diffuses from the cell.
    Protein Attributes:
    Sequence length:
    411
    Sequence:
    50:
    MSPARLRPRL | HFCLVLLLLL | VVPAAWGCGP | GRVVGSRRRP | PRKLVPLAYK | 
    100:
    QFSPNVPEKT | LGASGRYEGK | IARSSERFKE | LTPNYNPDII | FKDEENTGAD | 
    150:
    RLMTQRCKDR | LNSLAISVMN | QWPGVKLRVT | EGWDEDGHHS | EESLHYEGRA | 
    200:
    VDITTSDRDR | NKYGLLARLA | VEAGFDWVYY | ESKAHVHCSV | KSEHSAAAKT | 
    250:
    GGCFPAGAQV | RLESGARVAL | SAVRPGDRVL | AMGEDGSPTF | SDVLIFLDRE | 
    300:
    PHRLRAFQVI | ETQDPPRRLA | LTPAHLLFTA | DNHTEPAARF | RATFASHVQP | 
    350:
    GQYVLVAGVP | GLQPARVAAV | STHVALGAYA | PLTKHGTLVV | EDVVASCFAA | 
    400:
    VADHHLAQLA | FWPLRLFHSL | AWGSWTPGEG | VHWYPQLLYR | LGRLLLEEGS | 
    411:
    FHPLGMSGAG | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    MIM:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human IHH
    Cat.:
    E0025m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IHH
    Cat.:
    E0025h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human IHH
    Cat.:
    E0025c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IHH
    Cat.:
    U0025m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IHH
    Cat.:
    U0025h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IHH
    Cat.:
    U0025c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IHH
    Polyclonal Antibody for Human IHH
    Cat.:
    P0025Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IHH
    Cat.:
    P0025Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human IHH
    Monoclonal Antibody for Human IHH
    Monoclonal Antibody for Human IHH
    Protein for Human IHH
    Protein for Human IHH
    Protein for Human IHH

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Expression of Sonic hedgehog and its receptor Patched/Smoothened in human cancer cell lines and embryonic organs."
      Tate G. , Kishimoto K. , Mitsuya T.
      J. Biochem. Mol. Biol. Biophys.4:27-34(2000)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    4. 4.
      "Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog."
      Marigo V. , Roberts D.J. , Lee S.M.K. , Tsukurov O. , Levi T. , Gastier J.M. , Epstein D.J. , Gilbert D.J. , Copeland N.G. , Seidman C.E. , Jenkins N.A. , Seidman J.G. , McMahon A.P. , Tabin C.
      Genomics28:44-51(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 100-411
      tissue: Fetal lung.
    5. 5.
      "Products, genetic linkage and limb patterning activity of a murine hedgehog gene."
      Chang D.T. , Lopez A. , von Kessler D.P. , Chiang C. , Simandl B.K. , Zhao R. , Seldin M.F. , Fallon J.F. , Beachy P.A.
      Development120:3339-3353(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 124-172
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-28
    7. 7.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-282
      tissue: Plasma.
    8. 8.
      "All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."
      Kavran J.M. , Ward M.D. , Oladosu O.O. , Mulepati S. , Leahy D.J.
      J. Biol. Chem.285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 29-193 IN COMPLEXES WITH CALCIUM IONS; ZINC IONS; BOC AND CDON;DOMAIN;INTERACTION WITH BOC AND CDON
    9. 9.
      "Indian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels."
      Ma G. , Yu J. , Xiao Y. , Chan D. , Gao B. , Hu J. , He Y. , Guo S. , Zhou J. , Zhang L. , Gao L. , Zhang W. , Kang Y. , Cheah K.S. , Feng G. , Guo X. , Wang Y. , Zhou C.Z. , more...
      Cell Res.21:1343-1357(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.44 ANGSTROMS) OF 28-202 OF WILD TYPE AND VARIANTS BDA1 LYS-95; GLU-100 AND LYS-131 IN COMPLEX WITH ZINC IONS;FUNCTION;SUBUNIT;INTERACTION WITH PTCH1;SUBCELLULAR LOCATION;CHOLESTERYLATION;PALMITOYLATION;MUTAGENESIS OF GLU-95;DOMAIN;CHARACTERIZATION OF VARIANTS BDA1 LYS-95; ASN-100; GLU-100 AND LYS-131
    10. 10.
      "Mutations in IHH, encoding Indian hedgehog, cause brachydactyly type A-1."
      Gao B. , Guo J. , She C. , Shu A. , Yang M. , Tan Z. , Yang X. , Guo S. , Feng G. , He L.
      Nat. Genet.28:386-388(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BDA1 LYS-95; GLU-100 AND LYS-131
    11. 11.
      "A novel mutation in the IHH gene causes brachydactyly type A1: a 95-year-old mystery resolved."
      McCready M.E. , Sweeney E. , Fryer A.E. , Donnai D. , Baig A. , Racacho L. , Warman M.L. , Hunter A.G.W. , Bulman D.E.
      Hum. Genet.111:368-375(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDA1 ASN-100
    12. 12.
      "Homozygous mutations in IHH cause acrocapitofemoral dysplasia, an autosomal recessive disorder with cone-shaped epiphyses in hands and hips."
      Hellemans J. , Coucke P.J. , Giedion A. , De Paepe A. , Kramer P. , Beemer F. , Mortier G.R.
      Am. J. Hum. Genet.72:1040-1046(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ACFD LEU-46 AND ALA-190
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