Protein name:
Interleukin-12 subunit beta (IL-12B) ;
Alternative:
IL-12 subunit p40 ;Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
Function:
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Location:
Secreted
Protein Attributes:
50:
MHPQQLVVSW | FSLVLLASPI | VAMWELEKNV | YVVELDWYPD | APGETVVLTC |
100:
DTPEEDGITW | TSDQSSEVLG | SGKTLTIQVK | EFGDAGQYTC | HKGGEALSRS |
150:
LLLLHKKEDG | IWSTDILKDQ | KEPKAKSFLK | CEAKDYSGHF | TCWWLTAIST |
200:
DLKFSVKSSR | GSSDPRGVTC | GAALLSAEKV | SLEHREYNKY | TVECQEGSAC |
250:
PAAEESLLIE | VVVEAVHKLK | YENYTSSFFI | RDIIKPDPPK | NLQLRPLKNS |
300:
RQVEVSWEYP | DTWSTPHSYF | SLTFCVQVQG | KNKREKKLFM | DQTSAKVTCH |
327:
KDANVRVQAR | DRYYSSFWSE | WASVSCS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Dog
Bovine
Human
ELISA Kit for Bovine IL-12B
ELISA Kit for Bovine IL-12B
ELISA Kit for Bovine IL-12B
ELISA Kit for Bovine IL-12B
ELISA Kit for Bovine IL-12B
CLIA Kit for Bovine IL-12B
CLIA Kit for Bovine IL-12B
CLIA Kit for Bovine IL-12B
CLIA Kit for Bovine IL-12B
CLIA Kit for Bovine IL-12B
Polyclonal Antibody for Bovine IL-12B
Polyclonal Antibody for Bovine IL-12B
Polyclonal Antibody for Bovine IL-12B
Polyclonal Antibody for Bovine IL-12B
Polyclonal Antibody for Bovine IL-12B
Monoclonal Antibody for Bovine IL-12B
Monoclonal Antibody for Bovine IL-12B
Monoclonal Antibody for Bovine IL-12B
Monoclonal Antibody for Bovine IL-12B
Monoclonal Antibody for Bovine IL-12B
Protein for Bovine IL-12B
Protein for Bovine IL-12B
Protein for Bovine IL-12B
Protein for Bovine IL-12B
Protein for Bovine IL-12B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Holstein .
tissue :
Lymphoid tissue .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Belted Galloway .
tissue :
Peripheral blood .