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Index > Protein center > IL12B(Gene name) > Bovine
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  • IL12B (Gene name),
  • Interleukin-12 subunit beta (Protein name ),  IL12B_BOVIN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    IL12B;
    Protein name:
    Interleukin-12 subunit beta(IL-12B);
    Alternative:
    IL-12 subunit p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit(CLMF p40);
    Organism:
    Bovine (Bos taurus). 
    General Annotation
    Sub Unit:
    Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
    Function:
    Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    327
    Sequence:
    50:
    MHPQQLVVSW | FSLVLLASPI | VAMWELEKNV | YVVELDWYPD | APGETVVLTC | 
    100:
    DTPEEDGITW | TSDQSSEVLG | SGKTLTIQVK | EFGDAGQYTC | HKGGEALSRS | 
    150:
    LLLLHKKEDG | IWSTDILKDQ | KEPKAKSFLK | CEAKDYSGHF | TCWWLTAIST | 
    200:
    DLKFSVKSSR | GSSDPRGVTC | GAALLSAEKV | SLEHREYNKY | TVECQEGSAC | 
    250:
    PAAEESLLIE | VVVEAVHKLK | YENYTSSFFI | RDIIKPDPPK | NLQLRPLKNS | 
    300:
    RQVEVSWEYP | DTWSTPHSYF | SLTFCVQVQG | KNKREKKLFM | DQTSAKVTCH | 
    327:
    KDANVRVQAR | DRYYSSFWSE | WASVSCS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Bovine IL-12B
    Cat.:
    E0058p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Bovine IL-12B
    Cat.:
    E0058m
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Bovine IL-12B
    Cat.:
    E0058d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine IL-12B
    Cat.:
    E0058b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Bovine IL-12B
    Cat.:
    E0058h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine IL-12B
    Cat.:
    U0058h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine IL-12B
    Cat.:
    U0058b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine IL-12B
    Cat.:
    U0058m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine IL-12B
    Cat.:
    U0058p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Bovine IL-12B
    Cat.:
    U0058d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Bovine IL-12B
    Cat.:
    P0058Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Bovine IL-12B
    Polyclonal Antibody for Bovine IL-12B
    Polyclonal Antibody for Bovine IL-12B
    Polyclonal Antibody for Bovine IL-12B
    Cat.:
    P0058Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Bovine IL-12B
    Monoclonal Antibody for Bovine IL-12B
    Monoclonal Antibody for Bovine IL-12B
    Monoclonal Antibody for Bovine IL-12B
    Monoclonal Antibody for Bovine IL-12B
    Protein for Bovine IL-12B
    Protein for Bovine IL-12B
    Protein for Bovine IL-12B
    Protein for Bovine IL-12B
    Protein for Bovine IL-12B

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    References
    1. 1.
      "Enzymatic amplification and molecular cloning of cDNA encoding the small and large subunits of bovine interleukin 12."
      Zarlenga D.S. , Canals A. , Aschenbrenner R.A. , Gasbarre L.C.
      Biochim. Biophys. Acta1270:215-217(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Holstein.
      tissue: Lymphoid tissue.
    2. 2.
      "U.S. veterinary immune reagent network: expressed bovine gene sequences."
      U.S. Veterinary Immune Reagent Network , Hudgens T. , Tompkins D. , Baldwin C.L.
      Submitted (2007-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Belted Galloway.
      tissue: Peripheral blood.
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