Protein name:
Interleukin-12 subunit beta (IL-12B) ;
Alternative:
IL-12 subunit p40 ;Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) ;NK cell stimulatory factor chain 2 (NKSF2) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
Function:
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Location:
Secreted
Protein Attributes:
50:
MCHQQLVISW | FSLVFLASPL | VAIWELKKDV | YVVELDWYPD | APGEMVVLTC |
100:
DTPEEDGITW | TLDQSSEVLG | SGKTLTIQVK | EFGDAGQYTC | HKGGEVLSHS |
150:
LLLLHKKEDG | IWSTDILKDQ | KEPKNKTFLR | CEAKNYSGRF | TCWWLTTIST |
200:
DLTFSVKSSR | GSSDPQGVTC | GAATLSAERV | RGDNKEYEYS | VECQEDSACP |
250:
AAEESLPIEV | MVDAVHKLKY | ENYTSSFFIR | DIIKPDPPKN | LQLKPLKNSR |
300:
QVEVSWEYPD | TWSTPHSYFS | LTFCVQVQGK | SKREKKDRVF | TDKTSATVIC |
328:
RKNASISVRA | QDRYYSSSWS | EWASVPCS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Dog
Bovine
Human
ELISA Kit for Human IL-12B
ELISA Kit for Human IL-12B
ELISA Kit for Human IL-12B
ELISA Kit for Human IL-12B
ELISA Kit for Human IL-12B
CLIA Kit for Human IL-12B
CLIA Kit for Human IL-12B
CLIA Kit for Human IL-12B
CLIA Kit for Human IL-12B
CLIA Kit for Human IL-12B
Polyclonal Antibody for Human IL-12B
Polyclonal Antibody for Human IL-12B
Polyclonal Antibody for Human IL-12B
Polyclonal Antibody for Human IL-12B
Polyclonal Antibody for Human IL-12B
Monoclonal Antibody for Human IL-12B
Monoclonal Antibody for Human IL-12B
Monoclonal Antibody for Human IL-12B
Monoclonal Antibody for Human IL-12B
Monoclonal Antibody for Human IL-12B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Gubler U.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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4.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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tissue :
Brain .
7.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SIMILARITY TO IL-6 RECEPTOR
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT TRP-319
11.
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Cited for : INVOLVEMENT IN IMD29
12.
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more...
Immunity13:715-725(2000)
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[
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[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH IL23A
13.
"Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds."
Picard C.
,
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more...
Am. J. Hum. Genet.70:336-348(2002)
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Cited for : INVOLVEMENT IN IMD29
14.
"Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis."
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Cited for : ASSOCIATION WITH PSORIASIS
15.
"Genetic variants of the IL-23R pathway: association with psoriatic arthritis and psoriasis vulgaris, but no specific risk factor for arthritis."
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[
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Cited for : ASSOCIATION WITH PSORIASIS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-328 ALONE AND IN COMPLEX WITH IL12A;GLYCOSYLATION AT ASN-222;DISULFIDE BONDS
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A AND ANTIBODY
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 23-328 IN COMPLEX WITH IL23A;SUBUNIT