Il12b ELISA Kit for Mouse(Mus musculus) | EIAab.comIl12b ELISA Kit for Mouse(Mus musculus)

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Il12b (Gene name),

Interleukin-12 subunit beta (Protein name ), IL12B_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Il12b;

Protein name:

Interleukin-12 subunit beta(IL-12B);

Alternative:

IL-12 subunit p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit(CLMF p40);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.

Function:

Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

335

Sequence:

50:

100:

150:

200:

250:

300:

335:

TEVQCKGGNV | CVQAQDRYYN | SSCSKWACVP | CRVRS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P43432

KEGG:

mmu:16160

String:

P43432

UniGene:

Mm.239707

Pfam:

PF10420

Uniprot:

P43432

FOR

ELISA Kit for Mouse IL-12B

Cat.:

E0058p

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Packing:

96T

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ELISA Kit for Mouse IL-12B

Cat.:

E0058m

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96T

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ELISA Kit for Mouse IL-12B

Cat.:

E0058d

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96T

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ELISA Kit for Mouse IL-12B

Cat.:

E0058b

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Manual:

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96T

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ELISA Kit for Mouse IL-12B

Cat.:

E0058h

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96T

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CLIA Kit for Mouse IL-12B

Cat.:

U0058h

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Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse IL-12B

Cat.:

U0058b

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse IL-12B

Cat.:

U0058m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Mouse IL-12B

Cat.:

U0058p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

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CLIA Kit for Mouse IL-12B

Cat.:

U0058d

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse IL-12B

Cat.:

P0058Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse IL-12B

Cat.:

P0058Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse IL-12B

Protein for Mouse IL-12B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and expression of murine IL-12."
Schoenhaut D.S. , Chua A.O. , Wolitzky A.G. , Quinn P.M. , Dwyer C.M. , Gately M.K. , Gubler U.
J. Immunol.148:3433-3440(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6.
tissue: Spleen.
2.

"Structure and chromosomal location of the mouse interleukin-12 p35 and p40 subunit genes."
Tone Y. , Thompson S.A. , Babik J.M. , Nolan K.F. , Tone M. , Raven C. , Waldmann H.
Eur. J. Immunol.26:1222-1227(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Sequence polymorphisms in the chemokines Scya1 (TCA-3), Scya2 (monocyte chemoattractant protein (MCP)-1), and Scya12 (MCP-5) are candidates for eae7, a locus controlling susceptibility to monophasic remitting/nonrelapsing experimental allergic encephalomyelitis."
Teuscher C. , Butterfield R.J. , Ma R.Z. , Zachary J.F. , Doerge R.W. , Blankenhorn E.P.
J. Immunol.163:2262-2266(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS THR-169 AND LEU-294
strain: B10.S/J.
strain: SJL/J.
tissue: Spleen.
4.

"Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12."
Oppmann B. , Lesley R. , Blom B. , Timans J.C. , Xu Y. , Hunte B. , Vega F. , Yu N. , Wang J. , Singh K.P. , Zonin F. , Vaisberg E. , Churakova T. , Liu M.-R. , Gorman D. , Wagner J. , Zurawski S. , Liu Y.-J. , more...
Immunity13:715-725(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH IL23A

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