Protein name:
Interleukin-12 subunit beta (IL-12B) ;
Alternative:
IL-12 subunit p40 ;Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40) ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Heterodimer with IL12A; disulfide-linked. The heterodimer is known as interleukin IL-12. Heterodimer with IL23A; disulfide-linked. The heterodimer is known as interleukin IL-23. Also secreted as a monomer.
Function:
Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Subcellular Location:
Secreted
Protein Attributes:
50:
MHLQQLVVSW | FSLVWLASPI | VAIWELEKNV | YVVELDWYPN | APGEMVVLTC |
100:
NTPEEDGITW | TSDQSSEVLG | TGKTLTIHVK | EFGDAGQYTC | RKGGAVLSQS |
150:
LLLLHKKEDG | IWSTDILKDQ | KEPKNKSFLK | CEAKNYSGRF | TCWWLTAIST |
200:
DLKFSVKSSR | GSTDPRGVTC | GTATLSEDLG | EYKKYRVECQ | EGSACPAAEE |
250:
SLPIEVVLEA | VHKLKYENYT | SSFFIRDIIK | PDPPKNLQLN | PLKNSRHVEI |
300:
SWEYPDTWST | PHSYFSLMFG | VQVQGKNKRE | KKDKLFTDQI | SAKVTCHKDA |
324:
NIRVQARDRY | YSSSWSEWAS | VSCN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Dog
Bovine
Human
Polyclonal Antibody for Pig IL-12B
Polyclonal Antibody for Pig IL-12B
Polyclonal Antibody for Pig IL-12B
Polyclonal Antibody for Pig IL-12B
Polyclonal Antibody for Pig IL-12B
Monoclonal Antibody for Pig IL-12B
Monoclonal Antibody for Pig IL-12B
Monoclonal Antibody for Pig IL-12B
Monoclonal Antibody for Pig IL-12B
Monoclonal Antibody for Pig IL-12B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Spleen .