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Index > Protein center > IL34(Gene name) > Human
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  • IL34 (Gene name),
  • Interleukin-34 (Protein name ),  IL34_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    IL34(C16orf77);
    Protein name:
    Interleukin-34(IL-34);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    242
    Sequence:
    50:
    MPRGFTWLRY | LGIFLGVALG | NEPLEMWPLT | QNEECTVTGF | LRDKLQYRSR | 
    100:
    LQYMKHYFPI | NYKISVPYEG | VFRIANVTRL | QRAQVSEREL | RYLWVLVSLS | 
    150:
    ATESVQDVLL | EGHPSWKYLQ | EVETLLLNVQ | QGLTDVEVSP | KVESVLSLLN | 
    200:
    APGPNLKLVR | PKALLDNCFR | VMELLYCSCC | KQSSVLNWQD | CEVPSPQSCS | 
    242:
    PEPSLQYAAT | QLYPPPPWSP | SSPPHSTGSV | RPVRAQGEGL | LP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human IL-34
    Cat.:
    E2007b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human IL-34
    Cat.:
    E2007m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human IL-34
    Cat.:
    E2007r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human IL-34
    Cat.:
    E2007h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human IL-34
    Cat.:
    U2007h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human IL-34
    Cat.:
    U2007b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-34
    Cat.:
    U2007r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human IL-34
    Cat.:
    U2007m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human IL-34
    Cat.:
    P2007Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-34
    Cat.:
    P2007Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-34
    Cat.:
    P2007Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human IL-34
    Monoclonal Antibody for Human IL-34
    Monoclonal Antibody for Human IL-34
    Monoclonal Antibody for Human IL-34
    Monoclonal Antibody for Human IL-34
    Protein for Human IL-34
    Protein for Human IL-34
    Protein for Human IL-34
    Protein for Human IL-34

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    References
    1. 1.
      "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome."
      Lin H. , Lee E. , Hestir K. , Leo C. , Huang M. , Bosch E. , Halenbeck R. , Wu G. , Zhou A. , Behrens D. , Hollenbaugh D. , Linnemann T. , Qin M. , Wong J. , Chu K. , Doberstein S.K. , Williams L.T.
      Science320:807-811(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANT GLN-123
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT GLN-123
      tissue: Adipose tissue.
      tissue: Amygdala.
    3. 3.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "IL-34 and M-CSF share the receptor Fms but are not identical in biological activity and signal activation."
      Chihara T. , Suzu S. , Hassan R. , Chutiwitoonchai N. , Hiyoshi M. , Motoyoshi K. , Kimura F. , Okada S.
      Cell Death Differ.17:1917-1927(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CSF1R
    7. 7.
      "Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood."
      Eda H. , Zhang J. , Keith R.H. , Michener M. , Beidler D.R. , Monahan J.B.
      Cytokine52:215-220(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN RELEASE OF PROINFLAMMATORY CHEMOKINES
    8. 8.
      "Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells."
      Wei S. , Nandi S. , Chitu V. , Yeung Y.G. , Yu W. , Huang M. , Williams L.T. , Lin H. , Stanley E.R.
      J. Leukoc. Biol.88:495-505(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CSF1R
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