INS ELISA Kit for Human(Homo sapiens) | EIAab.comINS ELISA Kit for Human(Homo sapiens)

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Index > Protein center > INS(Gene name) > Human

INS (Gene name),

Insulin (Protein name ), INS_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (3)

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Gene name:

INS;

Protein name:

Insulin;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Function:

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

110

Sequence:

50:

100:

110:

SLYQLENYCN |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P01308

Pfam:

PF00049

String:

P01308

KEGG:

hsa:3630

UniGene:

Hs.272259

MIM:

125852

STRING:

9606.ENSP00000348986

Uniprot:

P01308

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ELISA Kit for Human Insulin

Cat.:

E0448b

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96T

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ELISA Kit for Human Insulin

Cat.:

E0448d

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96T

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ELISA Kit for Human Insulin

Cat.:

E0448c

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96T

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ELISA Kit for Human Insulin

Cat.:

E0448h

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96T

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ELISA Kit for Human Insulin

Cat.:

E0448p

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96T

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ELISA Kit for Human Insulin

MSDS:

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ELISA Kit for Human Insulin

Cat.:

E0448m

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96T

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ELISA Kit for Human Insulin

Cat.:

E0448r

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Packing:

96T

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CLIA Kit for Human Insulin

MSDS:

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CLIA Kit for Human Insulin

Cat.:

U0448m

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Packing:

96T

CLIA Kit for Human Insulin

Cat.:

U0448r

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96T

CLIA Kit for Human Insulin

Cat.:

U0448h

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Packing:

96T

CLIA Kit for Human Insulin

Cat.:

U0448c

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96T

CLIA Kit for Human Insulin

Cat.:

U0448p

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96T

CLIA Kit for Human Insulin

Cat.:

U0448d

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96T

CLIA Kit for Human Insulin

Cat.:

U0448b

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96T

Polyclonal Antibody for Human Insulin

Cat.:

P0448Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Insulin

Cat.:

P0448Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Insulin

Cat.:

P0448Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Insulin

Monoclonal Antibody for Human Insulin

Cat.:

M0448h

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Packing:

40ug

Monoclonal Antibody for Human Insulin

Protein for Human Insulin

Cat.:

R0448h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human Insulin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Inhibition of SREBP by a Small Molecule, Betulin, Improves Hyperlipidemia and Insulin Resistance and Reduces Atherosclerotic Plaques"

Jing-Jie Tang, Jia-Gui Li, Wei Qi, Wen-Wei Qiu, Pei-Shan Li, Bo-Liang Li, Bao-Liang Song

From:Cell Metabolism, Volume 13, Issue 1, 44-56, 5 January 2011

[2].

"The study of soluble intercellular adhesion molecule-1 and ghrelin in adolescents with family history of type 2 diabetes"

BW Liu, Q Lu, CM Ma, et al.

From:Endocrine

[3].

"Coexistence of non-alcoholic fatty liver disease with elevated alanine aminotransferase is associated with insulin resistance in young Han males"

R Wang, Q Lu, J Feng, et al.

From:Endocrine

References

1.

"Sequence of the human insulin gene."
Bell G.I. , Pictet R.L. , Rutter W.J. , Cordell B. , Tischer E. , Goodman H.M.
Nature284:26-32(1980) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Genetic variation in the human insulin gene."
Ullrich A. , Dull T.J. , Gray A. , Brosius J. , Sures I.
Science209:612-615(1980) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Nucleotide sequence of a cDNA clone encoding human preproinsulin."
Bell G.I. , Swain W.F. , Pictet R.L. , Cordell B. , Goodman H.M. , Rutter W.J.
Nature282:525-527(1979) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Nucleotide sequence of human preproinsulin complementary DNA."
Sures I. , Goeddel D.V. , Gray A. , Ullrich A.
Science208:57-59(1980) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR."
Lucassen A.M. , Julier C. , Beressi J.-P. , Boitard C. , Froguel P. , Lathrop M. , Bell J.I.
Nat. Genet.4:305-310(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Insulinomas and expression of an insulin splice variant."
Minn A.H. , Kayton M. , Lorang D. , Hoffmann S.C. , Harlan D.M. , Libutti S.K. , Shalev A.
Lancet363:363-367(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
7.

"Global haplotype diversity in the human insulin gene region."
Stead J.D.H. , Hurles M.E. , Jeffreys A.J.
Genome Res.13:2101-2111(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Pancreas.
11.

"Description of a novel RFLP diallelic polymorphism (-127 BsgI C/G) within the 5' region of insulin gene."
Fajardy I.I. , Weill J.J. , Stuckens C.C. , Danze P.M.P.
Submitted (1998-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-59
tissue: Blood.
12.

"Amino-acid sequence of human insulin."
Nicol D.S.H.W. , Smith L.F.
Nature187:483-485(1960) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-54 AND 90-110
13.

"Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide."
Oyer P.E. , Cho S. , Peterson J.D. , Steiner D.F.
J. Biol. Chem.246:1375-1386(1971) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-87
14.

"The amino acid sequence of the C-peptide of human proinsulin."
Ko A. , Smyth D.G. , Markussen J. , Sundby F.
Eur. J. Biochem.20:190-199(1971) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-87
15.

"Total synthesis of human insulin under directed formation of the disulfide bonds."
Sieber P. , Kamber B. , Hartmann A. , Joehl A. , Riniker B. , Rittel W.
Helv. Chim. Acta57:2617-2621(1974) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS
16.

"Studies on polypeptides, IV. The synthesis of C-peptide of human proinsulin."
Naithani V.K.
Hoppe-Seyler's Z. Physiol. Chem.354:659-672(1973) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 57-87
17.

"Synthesis of peptides with the properties of human proinsulin C peptides (hC peptide). 3. Synthesis of the sequences 14-17 and 9-13 of human proinsulin C peptides."
Geiger R. , Volk A.
Chem. Ber.106:199-205(1973) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 65-69 AND 70-73
18.

"Synthesis of peptides with the properties of human proinsulin C peptides (hC peptide). I. Scheme for the synthesis and preparation of the sequence 28-31 of human proinsulin C peptide."
Geiger R. , Jaeger G. , Keonig W. , Treuth G.
Chem. Ber.106:188-192(1973) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 84-87
19.

"Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding [SerB24]insulin."
Haneda M. , Chan S.J. , Kwok S.C.M. , Rubenstein A.H. , Steiner D.F.
Proc. Natl. Acad. Sci. U.S.A.80:6366-6370(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LOS ANGELES SER-48
20.

"Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution."
Shoelson S. , Fickova M. , Haneda M. , Nahum A. , Musso G. , Kaiser E.T. , Rubenstein A.H. , Tager H.
Proc. Natl. Acad. Sci. U.S.A.80:7390-7394(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LOS ANGELES SER-48 AND CHICAGO LEU-49
21.

"A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia."
Chan S.J. , Seino S. , Gruppuso P.A. , Schwartz R. , Steiner D.F.
Proc. Natl. Acad. Sci. U.S.A.84:2194-2197(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI ASP-34
22.

"Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val-->Leu) isolated from the pancreas."
Sakura H. , Iwamoto Y. , Sakamoto Y. , Kuzuya T. , Hirata H.
J. Clin. Invest.78:1666-1672(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT WAKAYAMA LEU-92
23.

"Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction."
Barbetti F. , Raben N. , Kadowaki T. , Cama A. , Accili D. , Gabbay K.H. , Merenich J.A. , Taylor S.I. , Roth J.
J. Clin. Endocrinol. Metab.71:164-169(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI HIS-89
24.

"Posttranslational cleavage of proinsulin is blocked by a point mutation in familial hyperproinsulinemia."
Shibasaki Y. , Kawakami T. , Kanazawa Y. , Akanuma Y. , Takaku F.
J. Clin. Invest.76:378-380(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI HIS-89
25.

"A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto)."
Yano H. , Kitano N. , Morimoto M. , Polonsky K.S. , Imura H. , Seino Y.
J. Clin. Invest.89:1902-1907(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FHPRI LEU-89
26.

"Toward the solution structure of human insulin: sequential 2D 1H NMR assignment of a des-pentapeptide analogue and comparison with crystal structure."
Hua Q.-X. , Weiss M.A.
Biochemistry29:10545-10555(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
27.

"Comparative 2D NMR studies of human insulin and des-pentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor recognition."
Hua Q.-X. , Weiss M.A.
Biochemistry30:5505-5515(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
28.

"Two-dimensional NMR studies of Des-(B26-B30)-insulin: sequence-specific resonance assignments and effects of solvent composition."
Hua Q.-X. , Weiss M.A.
Biochim. Biophys. Acta1078:101-110(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
29.

"Three-dimensional solution structure of an insulin dimer. A study of the B9(Asp) mutant of human insulin using nuclear magnetic resonance, distance geometry and restrained molecular dynamics."
Joergensen A.M.M. , Kristensen S.M. , Led J.J. , Balschmidt P.
J. Mol. Biol.227:1146-1163(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
30.

"Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus."
Hua Q.-X. , Shoelson S.E. , Inouye K. , Weiss M.A.
Proc. Natl. Acad. Sci. U.S.A.90:582-586(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF VARIANT LOS-ANGELES SER-48
31.

"Solution structures of the R6 human insulin hexamer."
Chang X. , Joergensen A.M. , Bardrum P. , Led J.J.
Biochemistry36:9409-9422(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
32.

"Insulin gene mutations as a cause of permanent neonatal diabetes."
Stoy J. , Edghill E.L. , Flanagan S.E. , Ye H. , Paz V.P. , Pluzhnikov A. , Below J.E. , Hayes M.G. , Cox N.J. , Lipkind G.M. , Lipton R.B. , Greeley S.A. , Patch A.M. , Ellard S. , Steiner D.F. , Hattersley A.T. , Philipson L.H. , Bell G.I.
Proc. Natl. Acad. Sci. U.S.A.104:15040-15044(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PNDM ASP-24; ARG-32; SER-32; GLY-43; VAL-47; CYS-48; CYS-89; CYS-90; TYR-96 AND CYS-108
33.

"Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood."
Edghill E.L. , Flanagan S.E. , Patch A.M. , Boustred C. , Parrish A. , Shields B. , Shepherd M.H. , Hussain K. , Kapoor R.R. , Malecki M. , MacDonald M.J. , Stoy J. , Steiner D.F. , Philipson L.H. , Bell G.I. , Hattersley A.T. , Ellard S.
Diabetes57:1034-1042(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PNDM ASP-24; ASP-29; ARG-32; SER-32; PRO-35; GLY-43; VAL-47; CYS-48; ARG-84; CYS-89; CYS-90; SER-96; TYR-96; CYS-101; CYS-103 AND CYS-108;VARIANT MODY10 CYS-6;VARIANT MET-68
34.

"Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes."
Molven A. , Ringdal M. , Nordbo A.M. , Raeder H. , Stoy J. , Lipkind G.M. , Steiner D.F. , Philipson L.H. , Bergmann I. , Aarskog D. , Undlien D.E. , Joner G. , Sovik O. , Bell G.I. , Njolstad P.R.
Diabetes57:1131-1135(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MODY10 GLN-46;VARIANT IDDM2 CYS-55
35.

"Further evidence that mutations in INS can be a rare cause of Maturity-Onset Diabetes of the Young (MODY)."
Boesgaard T.W. , Pruhova S. , Andersson E.A. , Cinek O. , Obermannova B. , Lauenborg J. , Damm P. , Bergholdt R. , Pociot F. , Pisinger C. , Barbetti F. , Lebl J. , Pedersen O. , Hansen T.
BMC Med. Genet.11:42-42(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MODY10 HIS-6 AND GLN-46

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