Gene name:
SPAG9(HLC6;HSS;KIAA0516;MAPK8IP4;SYD1);
Protein name:
C-Jun-amino-terminal kinase-interacting protein 4(JIP-4;JNK-interacting protein 4);
Alternative:
Sunday driver 1;Human lung cancer oncogene 6 protein(HLC-6);Cancer/testis antigen 89(CT89);Mitogen-activated protein kinase 8-interacting protein 4;JNK-associated leucine-zipper protein(JLP);Protein highly expressed in testis(PHET);Proliferation-inducing protein 6;Sperm-associated antigen 9;Sperm surface protein;Sperm-specific protein;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. Interacts with MAX, MAPK8, MAPK9, MAPK10, MAPK14, MAP3K3, MYC, KNS2 and MAP2K4. Interaction with KNS2 is important in the formation of ternary complex with MAPK8. Interacts with NFKB1.
Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg-interaction.
Subcellular Location:
Isoform 5
Cytoplasmic vesicle
secretory vesicle
acrosome
Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Protein Attributes:
50:
MELEDGVVYQ | EEPGGSGAVM | SERVSGLAGS | IYREFERLIG | RYDEEVVKEL |
100:
MPLVVAVLEN | LDSVFAQDQE | HQVELELLRD | DNEQLITQYE | REKALRKHAE |
150:
EKFIEFEDSQ | EQEKKDLQTR | VESLESQTRQ | LELKAKNYAD | QISRLEEREA |
200:
ELKKEYNALH | QRHTEMIHNY | MEHLERTKLH | QLSGSDQLES | TAHSRIRKER |
250:
PISLGIFPLP | AGDGLLTPDA | QKGGETPGSE | QWKFQELSQP | RSHTSLKVSN |
300:
SPEPQKAVEQ | EDELSDVSQG | GSKATTPAST | ANSDVATIPT | DTPLKEENEG |
350:
FVKVTDAPNK | SEISKHIEVQ | VAQETRNVST | GSAENEEKSE | VQAIIESTPE |
400:
LDMDKDLSGY | KGSSTPTKGI | ENKAFDRNTE | SLFEELSSAG | SGLIGDVDEG |
450:
ADLLGMGREV | ENLILENTQL | LETKNALNIV | KNDLIAKVDE | LTCEKDVLQG |
500:
ELEAVKQAKL | KLEEKNRELE | EELRKARAEA | EDARQKAKDD | DDSDIPTAQR |
550:
KRFTRVEMAR | VLMERNQYKE | RLMELQEAVR | WTEMIRASRE | NPAMQEKKRS |
600:
SIWQFFSRLF | SSSSNTTKKP | EPPVNLKYNA | PTSHVTPSVK | KRSSTLSQLP |
650:
GDKSKAFDFL | SEETEASLAS | RREQKREQYR | QVKAHVQKED | GRVQAFGWSL |
700:
PQKYKQVTNG | QGENKMKNLP | VPVYLRPLDE | KDTSMKLWCA | VGVNLSGGKT |
750:
RDGGSVVGAS | VFYKDVAGLD | TEGSKQRSAS | QSSLDKLDQE | LKEQQKELKN |
800:
QEELSSLVWI | CTSTHSATKV | LIIDAVQPGN | ILDSFTVCNS | HVLCIASVPG |
850:
ARETDYPAGE | DLSESGQVDK | ASLCGSMTSN | SSAETDSLLG | GITVVGCSAE |
900:
GVTGAATSPS | TNGASPVMDK | PPEMEAENSE | VDENVPTAEE | ATEATEGNAG |
950:
SAEDTVDISQ | TGVYTEHVFT | DPLGVQIPED | LSPVYQSSND | SDAYKDQISV |
1000:
LPNEQDLVRE | EAQKMSSLLP | TMWLGAQNGC | LYVHSSVAQW | RKCLHSIKLK |
1050:
DSILSIVHVK | GIVLVALADG | TLAIFHRGVD | GQWDLSNYHL | LDLGRPHHSI |
1100:
RCMTVVHDKV | WCGYRNKIYV | VQPKAMKIEK | SFDAHPRKES | QVRQLAWVGD |
1150:
GVWVSIRLDS | TLRLYHAHTY | QHLQDVDIEP | YVSKMLGTGK | LGFSFVRITA |
1200:
LMVSCNRLWV | GTGNGVIISI | PLTETNKTSG | VPGNRPGSVI | RVYGDENSDK |
1250:
VTPGTFIPYC | SMAHAQLCFH | GHRDAVKFFV | AVPGQVISPQ | SSSSGTDLTG |
1300:
DKAGPSAQEP | GSQTPLKSML | VISGGEGYID | FRMGDEGGES | ELLGEDLPLE |
1321:
PSVTKAERSH | LIVWQVMYGN | E
Vaild Sequence:
Related Databases
Uniprot: