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Index > Protein center > Jmjd6(Gene name) > Rat
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  • Jmjd6 (Gene name),
  • Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (Protein name ),  JMJD6_RAT from NCBI database.
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  • Gene name:
    Jmjd6(Ptdsr);
    Protein name:
    Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6;
    Alternative:
    JmjC domain-containing protein 6;Histone arginine demethylase JMJD6;Lysyl-hydroxylase JMJD6;Jumonji domain-containing protein 6;Phosphatidylserine receptor(Protein PTDSR);Peptide-lysine 5-dioxygenase JMJD6;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with LUC7L2, LUC7L3 and U2AF2/U2AF65.
    Function:
    Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
    Subcellular Location:
    Nucleus nucleoplasm Nucleus nucleolus Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
    Protein Attributes:
    Sequence length:
    403
    Sequence:
    50:
    MNHKSKKRIR | EAKRSARPEL | KDSLDWTRHN | YYESYPLSPA | AVPDNVERAD | 
    100:
    ALQLSVKEFV | ERYERPYKPV | VLLNAQEGWS | AQEKWTLERL | KRKYRNQKFK | 
    150:
    CGEDNDGYSV | KMKMKYYIEY | MESTRDDSPL | YIFDSSYGEH | PKRRKLLEDY | 
    200:
    KVPKFFTDDL | FQYAGEKRRP | PYRWFVMGPP | RSGTGIHIDP | LGTSAWNALV | 
    250:
    QGHKRWCLFP | TNTPRELIKV | TREEGGNQQD | EAITWFNVIY | PRTQLPTWPP | 
    300:
    EFKPLEILQK | PGETVFVPGG | WWHVVLNLDT | TIAITQNFAS | STNFPVVWHK | 
    350:
    TVRGRPKLSR | KWYRILKQEH | PELAVLADAV | DLQESTGIAS | DSSSDSSSSS | 
    400:
    SSSSSDSDSE | CESGSEGDGT | THRRKKRRTC | SMVGNGDTTS | QDDCVSKERS | 
    403:
    SSR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
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    E1916h
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    96T
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    ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    E1916m
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    Packing:
    96T
    ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
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    E1916r
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    96T
    ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
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    E1916b
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    96T
    ELISA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    E1916c
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    Packing:
    96T
    CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    U1916c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    U1916m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    U1916h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    U1916r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    U1916b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    P1916Rb-m
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    P1916Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Cat.:
    P1916Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Polyclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Monoclonal Antibody for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
    Protein for Rat Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

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    Linearity
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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
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