Protein name:
Mast/stem cell growth factor receptor Kit (SCFR) ;
Alternative:
Tyrosine-protein kinase Kit ;Proto-oncogene c-Kit ;
CD:
CD117 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer in the absence of bound KITLG/SCF. Homodimer in the presence of bound KITLG/SCF, forming a heterotetramer with two KITLG/SCF molecules. Interacts (via phosphorylated tyrosine residues) with the adapter proteins GRB2 and GRB7 (via SH2 domain), and SH2B2/APS. Interacts (via C-terminus) with MPDZ (via the tenth PDZ domain). Interacts (via phosphorylated tyrosine residues) with the protein phosphatases PTPN6/SHP-1 (via SH2 domain), PTPN11/SHP-2 (via SH2 domain) and PTPRU (By similarity). Interacts with the protein kinase FES/FPS. Interacts with PLCG1. Interacts (via phosphorylated tyrosine residues) with PIK3R1.
Function:
Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Subcellular Location:
Isoform 3
Cytoplasm
Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head.
Protein Attributes:
50:
MRGARGAWDL | LCVLLVLLRG | QTATSQPSAS | PGEPSPPSIH | PAQSELIVEA |
100:
GDTLSLTCID | PDFVRWTFKT | YFNEMVENKK | NEWIQEKAEA | TRTGTYTCSN |
150:
SNGLTSSIYV | FVRDPAKLFL | VGLPLFGKED | SDALVRCPLT | DPQVSNYSLI |
200:
ECDGKSLPTD | LTFVPNPKAG | ITIKNVKRAY | HRLCVRCAAQ | RDGTWLHSDK |
250:
FTLKVRAAIK | AIPVVSVPET | SHLLKKGDTF | TVVCTIKDVS | TSVNSMWLKM |
300:
NPQPQHIAQV | KHNSWHRGDF | NYERQETLTI | SSARVDDSGV | FMCYANNTFG |
350:
SANVTTTLKV | VEKGFINISP | VKNTTVFVTD | GENVDLVVEY | EAYPKPEHQQ |
400:
WIYMNRTSAN | KGKDYVKSDN | KSNIRYVNQL | RLTRLKGTEG | GTYTFLVSNS |
450:
DASASVTFNV | YVNTKPEILT | YDRLINGMLQ | CVAEGFPEPT | IDWYFCTGAE |
500:
QRCTTPVSPV | DVQVQNVSVS | PFGKLVVQSS | IDSSVFRHNG | TVECKASNDV |
550:
GKSSAFFNFA | FKGNNKEQIQ | AHTLFTPLLI | GFVVAAGAMG | IIVMVLTYKY |
600:
LQKPMYEVQW | KVVEEINGNN | YVYIDPTQLP | YDHKWEFPRN | RLSFGKTLGA |
650:
GAFGKVVEAT | AYGLIKSDAA | MTVAVKMLKP | SAHLTEREAL | MSELKVLSYL |
700:
GNHMNIVNLL | GACTVGGPTL | VITEYCCYGD | LLNFLRRKRD | SFIFSKQEEQ |
750:
AEAALYKNLL | HSTEPSCDSS | NEYMDMKPGV | SYVVPTKTDK | RRSARIDSYI |
800:
ERDVTPAIME | DDELALDLDD | LLSFSYQVAK | GMAFLASKNC | IHRDLAARNI |
850:
LLTHGRITKI | CDFGLARDIR | NDSNYVVKGN | ARLPVKWMAP | ESIFSCVYTF |
900:
ESDVWSYGIF | LWELFSLGSS | PYPGMPVDSK | FYKMIKEGFR | MVSPEHAPAE |
950:
MYDVMKTCWD | ADPLKRPTFK | QVVQLIEKQI | SDSTKHIYSN | LANCNPNPEN |
979:
PVVVDHSVRV | NSVGSSASST | QPLLVHEDA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Dog
Pig
Chicken
Polyclonal Antibody for Mouse SCFR
Polyclonal Antibody for Mouse SCFR
Polyclonal Antibody for Mouse SCFR
Polyclonal Antibody for Mouse SCFR
Polyclonal Antibody for Mouse SCFR
Polyclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
Monoclonal Antibody for Mouse SCFR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT GLU-207
strain :
BALB/c .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Medulla oblongata .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 3);TISSUE SPECIFICITY
strain :
ICR .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);MUTAGENESIS OF PHE-860
strain :
C57BL/6J .
5.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6 .
strain :
FVB/N .
tissue :
Brain .
tissue :
Mammary tumor .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
strain :
BALB/c .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBUNIT
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN ACTIVATION OF PLCG1;INTERACTION WITH PLCG1;ALTERNATIVE SPLICING;PHOSPHORYLATION;GLYCOSYLATION;CHARACTERIZATION OF VARIANTS W37 LYS-586 AND W41 MET-835
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PIK3R1;FUNCTION IN PHOSPHORYLATION OF PIK3R1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION;SUBCELLULAR LOCATION;CATALYTIC ACTIVITY;PHOSPHORYLATION AT TYR-825;INTERACTION WITH PIK3R1;CHARACTERIZATION OF VARIANT W42 ASN-794;MUTAGENESIS OF TYR-723;TISSUE SPECIFICITY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;FUNCTION IN ACTIVATION OF PLCG1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PTPN6/SHP-1 AND PTPN11/SHP-2;FUNCTION IN PHOSPHORYLATION OF PTPN6/SHP-1;MUTAGENESIS OF TYR-571 AND TYR-573
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ROLE IN SPERMATOGENESIS AND FERTILITY
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FES/FPS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-571; TYR-573; TYR-706 AND TYR-938;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN MAST CELL MIGRATION;IN SIGNALING VIA FYN
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;TISSUE SPECIFICITY
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN MAST CELL DEGRANULATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLU-207
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 25-314 IN COMPLEX WITH KITLG/SCF;DISULFIDE BONDS;GLYCOSYLATION AT ASN-296 AND ASN-303
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT W42 ASN-794
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS W37 LYS-586; WV MET-664 AND W41 MET-835