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Index > Protein center > KLK3(Gene name) > Human
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  • KLK3 (Gene name),
  • Prostate-specific antigen (Protein name ),  KLK3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    KLK3(APS);
    Protein name:
    Prostate-specific antigen(PSA);
    Alternative:
    Kallikrein-3;Gamma-seminoprotein(Seminin);Semenogelase;P-30 antigen;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    261
    Sequence:
    50:
    MWVPVVFLTL | SVTWIGAAPL | ILSRIVGGWE | CEKHSQPWQV | LVASRGRAVC | 
    100:
    GGVLVHPQWV | LTAAHCIRNK | SVILLGRHSL | FHPEDTGQVF | QVSHSFPHPL | 
    150:
    YDMSLLKNRF | LRPGDDSSHD | LMLLRLSEPA | ELTDAVKVMD | LPTQEPALGT | 
    200:
    TCYASGWGSI | EPEEFLTPKK | LQCVDLHVIS | NDVCAQVHPQ | KVTKFMLCAG | 
    250:
    RWTGGKSTCS | GDSGGPLVCN | GVLQGITSWG | SEPCALPERP | SLYTKVVHYR | 
    261:
    KWIKDTIVAN | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human PSA
    Cat.:
    E0151h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PSA
    Cat.:
    E0151r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PSA
    Cat.:
    U0151r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PSA
    Cat.:
    U0151h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human PSA
    Cat.:
    P0151Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PSA
    Cat.:
    P0151Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human PSA
    Monoclonal Antibody for Human PSA
    Protein for Human PSA
    Protein for Human PSA

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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular cloning of human prostate specific antigen cDNA."
      Lundwall A. , Lilja H.
      FEBS Lett.214:317-322(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 4-238 (ISOFORM 2);ALTERNATIVE SPLICING
      tissue: Prostate.
    2. 2.
      "Human prostate specific antigen (PSA) gene: structure and linkage to the kallikrein-like gene, hGK-1."
      Digby M.R. , Zhang X.Y. , Richard R.I.
      Nucleic Acids Res.17:2137-2137(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Prostate.
    3. 3.
      "Genomic sequence of human prostate specific antigen (PSA)."
      Klobeck H.-G. , Combriato G. , Schulz P. , Arbusow V. , Fittler F.
      Nucleic Acids Res.17:3981-3981(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Characterization of the gene for prostate-specific antigen, a human glandular kallikrein."
      Lundwall A.
      Biochem. Biophys. Res. Commun.161:1151-1159(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Leukocyte.
    5. 5.
      "cDNA coding for the entire human prostate specific antigen shows high homologies to the human tissue kallikrein genes."
      Henttu P. , Vihko P.
      Biochem. Biophys. Res. Commun.160:903-910(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Prostate.
    6. 6.
      "Characterization of the prostate-specific antigen gene: a novel human kallikrein-like gene."
      Riegman P.H.J. , Vlietstra R.J. , van der Korput J.A.G.M. , Romijn J.C. , Trapman J.
      Biochem. Biophys. Res. Commun.159:95-102(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Prostate.
    7. 7.
      "A comparative analysis of prostate-specific antigen gene sequence in benign and malignant prostate tissue."
      Baffa R. , Moreno J.G. , Monne M. , Veronese M.L. , Gomella L.G.
      Urology47:795-800(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Prostate.
    8. 8.
      "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L. , Lee I. , Smith R. , Argonza-Barrett R. , Lei H. , McCuaig J. , Moss P. , Paeper B. , Wang K.
      Gene257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    9. 9.
      "Complex alternative splicing of the hKLK3 gene coding for the tumour marker PSA (prostate-specific-antigen)."
      Heuze-Vourc'h N. , Courty Y.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);ALTERNATIVE SPLICING
      tissue: Prostate.
    10. 10.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    11. 11.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    13. 13.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
      tissue: PNS.
      tissue: Prostate.
      tissue: Sciatic nerve.
    14. 14.
      "Molecular characterization of prostate-specific antigen messenger RNA expressed in breast tumors."
      Monne M. , Croce C.M. , Yu H. , Diamandis E.P.
      Cancer Res.54:6344-6347(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-176 (ISOFORM 1)
    15. 15.
      "Sequence of a cDNA clone encompassing the complete mature human prostate specific antigen (PSA) and an unspliced leader sequence."
      Schulz P. , Stucka R. , Feldmann H. , Combriato G. , Klobeck H.-G. , Fittler F.
      Nucleic Acids Res.16:6226-6226(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-261 (ISOFORM 1)
    16. 16.
      "Human prostate-specific antigen: structural and functional similarity with serine proteases."
      Watt K.W.K. , Lee P.J. , M'Timkulu T. , Chan W.P. , Loor R.
      Proc. Natl. Acad. Sci. U.S.A.83:3166-3170(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-261
    17. 17.
      "Isolation, characterization and amino-acid sequence of gamma-seminoprotein, a glycoprotein from human seminal plasma."
      Schaller J. , Akiyama K. , Tsuda R. , Hara M. , Marti T. , Rickli E.E.
      Eur. J. Biochem.170:111-120(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-261
    18. 18.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-32
    19. 19.
      "Identification of a novel proteoform of prostate specific antigen (SNP-L132I) in clinical samples by multiple reaction monitoring."
      Vegvari A. , Sjodin K. , Rezeli M. , Malm J. , Lilja H. , Laurell T. , Marko-Varga G.
      Mol. Cell. Proteomics12:2761-2773(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 126-138;VARIANT ILE-132
    20. 20.
      "Functionally active protein C inhibitor/plasminogen activator inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at high concentrations in human seminal plasma and complexes with prostate-specific antigen."
      Espana F. , Gilabert J. , Estelles A. , Romeu A. , Aznar J. , Cabo A.
      Thromb. Res.64:309-320(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
    21. 21.
      "A structural model for the prostate disease marker, human prostate-specific antigen."
      Villoutreix B.O. , Getzoff E.D. , Griffin J.H.
      Protein Sci.3:2033-2044(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    23. 23.
      "Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody."
      Menez R. , Michel S. , Muller B.H. , Bossus M. , Ducancel F. , Jolivet-Reynaud C. , Stura E.A.
      J. Mol. Biol.376:1021-1033(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.83 ANGSTROMS) OF 25-261 IN COMPLEX WITH SUBSTRATE AND ACTIVATING ANTIBODY;ENZYME REGULATION;ACTIVE SITE;DISULFIDE BONDS
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