KLK8 ELISA Kit for Human(Homo sapiens) | EIAab.comKLK8 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > KLK8(Gene name) > Human

KLK8 (Gene name),

Kallikrein-8 (Protein name ), KLK8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

KLK8(UNQ283/PRO322;NRPN;PRSS19;TADG14);

Protein name:

Kallikrein-8(hK8);

Alternative:

Ovasin;Neuropsin(NP);Serine protease TADG-14;Serine protease 19;Tumor-associated differentially expressed gene 14 protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SPINK9.

Function:

Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury.

Subcellular Location:

Secreted Cytoplasm Shows a cytoplasmic distribution in the keratinocytes.

Protein Attributes:

Sequence length:

260

Sequence:

50:

100:

150:

200:

250:

260:

WIKKIIGSKG |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O60259

UniGene:

Hs.104570

KEGG:

hsa:11202

SMR:

O60259

Pfam:

PF00089

MIM:

605644

Uniprot:

O60259

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ELISA Kit for Human hK8

Cat.:

E0690h

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96T

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ELISA Kit for Human hK8

Cat.:

E0690m

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96T

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ELISA Kit for Human hK8

Cat.:

E0690r

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96T

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CLIA Kit for Human hK8

Cat.:

U0690r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human hK8

Cat.:

U0690m

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MSDS:

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Packing:

96T

CLIA Kit for Human hK8

Cat.:

U0690h

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Packing:

96T

Polyclonal Antibody for Human hK8

Cat.:

P0690Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human hK8

Cat.:

P0690Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human hK8

Cat.:

P0690Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human hK8

Protein for Human hK8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"Proteomic biomarkers for psoriasis and psoriasis arthritis"

Reindl J, Pesek J, Krüger T, et al.

From:Journal of proteomics

References

1.

"Sequence analysis and expression of human neuropsin cDNA and gene."
Yoshida S. , Taniguchi M. , Hirata A. , Shiosaka S.
Gene213:9-16(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
tissue: Hippocampus.
2.

"Cloning of tumor-associated differentially expressed gene-14, a novel serine protease overexpressed by ovarian carcinoma."
Underwood L.J. , Tanimoto H. , Wang Y. , Shigemasa K. , Parmley T.H. , O'Brien T.J.
Cancer Res.59:4435-4439(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Ovary.
3.

"A novel form of human neuropsin, a brain-related serine protease, is generated by alternative splicing and is expressed preferentially in human adult brain."
Mitsui S. , Tsuruoka N. , Yamashiro K. , Nakazato H. , Yamaguchi N.
Eur. J. Biochem.260:627-634(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
4.

"Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
Gan L. , Lee I. , Smith R. , Argonza-Barrett R. , Lei H. , McCuaig J. , Moss P. , Paeper B. , Wang K.
Gene257:119-130(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer."
Magklara A. , Scorilas A. , Katsaros D. , Massobrio M. , Yousef G.M. , Fracchioli S. , Danese S. , Diamandis E.P.
Clin. Cancer Res.7:806-811(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3 AND 4);TISSUE SPECIFICITY
6.

"Molecular cloning and characterization of a novel serine protease, ovasin, a potential molecular marker for ovarian carcinomas."
Gan L. , Gelinas R. , Gown A.M. , Moss P. , Smith R. , Wang K.
Submitted (1998-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
7.

"Human kallikrein 8 and human kallikrein 9 are organized as a bicistronic operon."
Michael I.P. , Diamandis E.P.
Submitted (2005-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
8.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
12.

"Recent origin of a hominoid-specific splice form of neuropsin, a gene involved in learning and memory."
Li Y. , Qian Y.-P. , Yu X.-J. , Wang Y.-Q. , Dong D.-G. , Sun W. , Ma R.-M. , Su B.
Mol. Biol. Evol.21:2111-2115(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2)
13.

"Expression of the kallikrein gene family in normal and Alzheimer's disease brain."
Shimizu-Okabe C. , Yousef G.M. , Diamandis E.P. , Yoshida S. , Shiosaka S. , Fahnestock M.
NeuroReport12:2747-2751(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples."
Kuwae K. , Matsumoto-Miyai K. , Yoshida S. , Sadayama T. , Yoshikawa K. , Hosokawa K. , Shiosaka S.
Mol. Pathol.55:235-241(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
15.

"Human kallikrein 8, a novel biomarker for ovarian carcinoma."
Kishi T. , Grass L. , Soosaipillai A. , Scorilas A. , Harbeck N. , Schmalfeldt B. , Dorn J. , Mysliwiec M. , Schmitt M. , Diamandis E.P.
Cancer Res.63:2771-2774(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: USE AS A MARKER FOR OVARIAN CANCER
16.

"Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins."
Rajapakse S. , Ogiwara K. , Takano N. , Moriyama A. , Takahashi T.
FEBS Lett.579:6879-6884(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
17.

"A human-specific mutation leads to the origin of a novel splice form of neuropsin (KLK8), a gene involved in learning and memory."
Lu Z.-X. , Peng J. , Su B.
Hum. Mutat.28:978-984(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2)
18.

"SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes."
Scott F.L. , Sun J. , Whisstock J.C. , Kato K. , Bird P.I.
J. Biochem.142:435-442(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
19.

"SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."
Brattsand M. , Stefansson K. , Hubiche T. , Nilsson S.K. , Egelrud T.
J. Invest. Dermatol.129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPINK9

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