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Index > Protein center > KSR2(Gene name) > Human
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  • KSR2 (Gene name),
  • Kinase suppressor of Ras 2 (Protein name ),  KSR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    KSR2;
    Protein name:
    Kinase suppressor of Ras 2(hKSR2);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF.
    Function:
    Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    950
    Sequence:
    50:
    MDEENMTKSE | EQQPLSLQKA | LQQCELVQNM | IDLSISNLEG | LRTKCATSND | 
    100:
    LTQKEIRTLE | SKLVKYFSRQ | LSCKKKVALQ | ERNAELDGFP | QLRHWFRIVD | 
    150:
    VRKEVLEEIS | PGQLSLEDLL | EMTDEQVCET | VEKYGANREE | CARLNASLSC | 
    200:
    LRNVHMSGGN | LSKQDWTIQW | PTTETGKENN | PVCPPEPTPW | IRTHLSQSPR | 
    250:
    VPSKCVQHYC | HTSPTPGAPV | YTHVDRLTVD | AYPGLCPPPP | LESGHRSLPP | 
    300:
    SPRQRHAVRT | PPRTPNIVTT | VTPPGTPPMR | KKNKLKPPGT | PPPSSRKLIH | 
    350:
    LIPGFTALHR | SKSHEFQLGH | RVDEAHTPKA | KKKSKPLNLK | IHSSVGSCEN | 
    400:
    IPSQQRSPLL | SERSLRSFFV | GHAPFLPSTP | PVHTEANFSA | NTLSVPRWSP | 
    450:
    QIPRRDLGNS | IKHRFSTKYW | MSQTCTVCGK | GMLFGLKCKN | CKLKCHNKCT | 
    500:
    KEAPPCHLLI | IHRGDPARLV | RTESVPCDIN | NPLRKPPRYS | DLHISQTLPK | 
    550:
    TNKINKDHIP | VPYQPDSSSN | PSSTTSSTPS | SPAPPLPPSA | TPPSPLHPSP | 
    600:
    QCTRQQKNFN | LPASHYYKYK | QQFIFPDVVP | VPETPTRAPQ | VILHPVTSNP | 
    650:
    ILEGNPLLQI | EVEPTSENEE | VHDEAEESED | DFEEMNLSLL | SARSFPRKAS | 
    700:
    QTSIFLQEWD | IPFEQLEIGE | LIGKGRFGQV | YHGRWHGEVA | IRLIDIERDN | 
    750:
    EDQLKAFKRE | VMAYRQTRHE | NVVLFMGACM | SPPHLAIITS | LCKGRTLYSV | 
    800:
    VRDAKIVLDV | NKTRQIAQEI | VKGMGYLHAK | GILHKDLKSK | NVFYDNGKVV | 
    850:
    ITDFGLFSIS | GVLQAGRRED | KLRIQNGWLC | HLAPEIIRQL | SPDTEEDKLP | 
    900:
    FSKHSDVFAL | GTIWYELHAR | EWPFKTQPAE | AIIWQMGTGM | KPNLSQIGMG | 
    950:
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    String:
    UniGene:
    Pfam:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human hKSR2
    Cat.:
    E1806m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human hKSR2
    Cat.:
    E1806h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hKSR2
    Cat.:
    U1806h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hKSR2
    Cat.:
    U1806m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human hKSR2
    Cat.:
    P1806Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human hKSR2
    Cat.:
    P1806Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human hKSR2
    Monoclonal Antibody for Human hKSR2
    Protein for Human hKSR2
    Protein for Human hKSR2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    2. 2.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling."
      Channavajhala P.L. , Wu L. , Cuozzo J.W. , Hall J.P. , Liu W. , Lin L.-L. , Zhang Y.
      J. Biol. Chem.278:47089-47097(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-950 (ISOFORM 1);FUNCTION;INTERACTION WITH MAP2K; RAS; RAF; MAPK AND MAP3K8;TISSUE SPECIFICITY
      tissue: Testis.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 122-950 (ISOFORM 1)
    5. 5.
      "hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation."
      Channavajhala P.L. , Rao V.R. , Spaulding V. , Lin L.-L. , Zhang Y.G.
      Biochem. Biophys. Res. Commun.334:1214-1218(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK."
      Brennan D.F. , Dar A.C. , Hertz N.T. , Chao W.C. , Burlingame A.L. , Shokat K.M. , Barford D.
      Nature472:366-369(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.46 ANGSTROMS) OF 634-950 OF MUTANT ALA-786 IN COMPLEX WITH ATP AND MAP2K1;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;SUBUNIT;INTERACTION WITH BRAF AND MAP2K1;ACTIVE SITE;MUTAGENESIS OF ARG-718; ASP-786 AND ALA-879
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