LGALS3 ELISA Kit for Human(Homo sapiens) | EIAab.comLGALS3 ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > LGALS3(Gene name) > Human

LGALS3 (Gene name),

Galectin-3 (Protein name ), LEG3_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

Feedback

Gene name:

LGALS3(MAC2);

Protein name:

Galectin-3(Gal-3);

Alternative:

Carbohydrate-binding protein 35(CBP 35);35 kDa lectin;Galactoside-binding protein(GALBP);Galactose-specific lectin 3;L-31;IgE-binding protein;Lectin L-29;Laminin-binding protein;Mac-2 antigen;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.

Function:

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.

Subcellular Location:

Cytoplasm Nucleus Secreted Secreted by a non-classical secretory pathway and associates with the cell surface.

Protein Attributes:

Sequence length:

250

Sequence:

50:

100:

150:

200:

250:

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.531081

String:

P17931

KEGG:

hsa:3958

Pfam:

PF00337

MIM:

153619

STRING:

9606.ENSP00000254301

SMR:

P17931

Uniprot:

P17931

FOR

ELISA Kit for Human Gal-3

Cat.:

E0497m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Gal-3

Cat.:

E0497h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Gal-3

Cat.:

E0497r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Gal-3

Cat.:

E0497d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Gal-3

MSDS:

Please sign in first.

CLIA Kit for Human Gal-3

Cat.:

U0497d

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Gal-3

Cat.:

U0497r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Gal-3

MSDS:

Please sign in first.

CLIA Kit for Human Gal-3

Cat.:

U0497h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Gal-3

Cat.:

U0497m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Gal-3

Cat.:

P0497Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gal-3

Cat.:

P0497Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gal-3

Cat.:

P0497Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Gal-3

Monoclonal Antibody for Human Gal-3

Protein for Human Gal-3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Expression and clinical significance of galectin-3 in osteosarcoma"

X Zhou, J Jing, W Mao, et al.

From:Gene

References

1.

"Human IgE-binding protein: a soluble lectin exhibiting a highly conserved interspecies sequence and differential recognition of IgE glycoforms."
Robertson M.W. , Albrandt K. , Keller D. , Liu F.-T.
Biochemistry29:8093-8100(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIS-64 AND PRO-98
2.

"Molecular cloning of a human macrophage lectin specific for galactose."
Cherayil B. , Chaitovitz S. , Wong C. , Pillai S.
Proc. Natl. Acad. Sci. U.S.A.87:7324-7328(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-98
tissue: Carcinoma.
3.

"Human breast carcinoma cDNA encoding a galactoside-binding lectin homologous to mouse Mac-2 antigen."
Oda Y. , Leffler H. , Sakakura Y. , Kasai K. , Barondes S.H.
Gene99:279-283(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS HIS-64 AND PRO-98
4.

"Molecular cloning and chromosomal mapping of a human galactoside-binding protein."
Raz A. , Carmi P. , Raz T. , Hogan V. , Mohamed A. , Wolman S.R.
Cancer Res.51:2173-2178(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Decreased expression of Mac-2 (carbohydrate binding protein 35) and loss of its nuclear localization are associated with the neoplastic progression of colon carcinoma."
Lotz M.M. , Andrews C.W. Jr. , Korzelius C.A. , Lee E.C. , Steele G.D. Jr. , Clarke A. , Mercurio A.M.
Proc. Natl. Acad. Sci. U.S.A.90:3466-3470(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
6.

"The human LGALS3 (galectin-3) gene: determination of the gene structure and functional characterization of the promoter."
Kadrofske M.M. , Openo K.P. , Wang J.L.
Arch. Biochem. Biophys.349:7-20(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Human galectin-3 full-length cDNA."
Kato S.
Submitted (1997-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Gastric adenocarcinoma.
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Thalamus.
9.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
10.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS HIS-64 AND PRO-98
tissue: Skin.
13.

"L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I."
Huflejt M.E. , Turck C.W. , Lindstedt R. , Barondes S.H. , Leffler H.
J. Biol. Chem.268:26712-26718(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-6 AND SER-12
14.

"Mac-2 binding protein is a cell-adhesive protein of the extracellular matrix which self-assembles into ring-like structures and binds beta1 integrins, collagens and fibronectin."
Sasaki T. , Brakebusch C. , Engel J. , Timpl R.
EMBO J.17:1606-1613(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LGALS3BP
15.

"NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
Fukushi J. , Makagiansar I.T. , Stallcup W.B.
Mol. Biol. Cell15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGB1; ITGA3 AND CSPG4;SUBCELLULAR LOCATION;FUNCTION
16.

"The regulation of inflammation by galectin-3."
Henderson N.C. , Sethi T.
Immunol. Rev.230:160-171(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INFLAMMATION
17.

"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death."
Than N.G. , Romero R. , Goodman M. , Weckle A. , Xing J. , Dong Z. , Xu Y. , Tarquini F. , Szilagyi A. , Gal P. , Hou Z. , Tarca A.L. , Kim C.J. , Kim J.S. , Haidarian S. , Uddin M. , Bohn H. , Benirschke K. , more...
Proc. Natl. Acad. Sci. U.S.A.106:9731-9736(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
18.

"Dynamics of galectin-3 in the nucleus and cytoplasm."
Haudek K.C. , Spronk K.J. , Voss P.G. , Patterson R.J. , Wang J.L. , Arnoys E.J.
Biochim. Biophys. Acta1800:181-189(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution."
Seetharaman J. , Kanigsberg A. , Slaaby R. , Leffler H. , Barondes S.H. , Rini J.M.
J. Biol. Chem.273:13047-13052(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 114-250

Product Feedback Wall

* Email:
*Comments: