Gene name:
LIMA1 (PP624;EPLIN;SREBP3) ;
Protein name:
LIM domain and actin-binding protein 1 ;
Alternative:
Epithelial protein lost in neoplasm ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.
Subcellular Location:
Cytoplasm
Cell junction
focal adhesion
Cytoplasm
cytoskeleton
This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.
Protein Attributes:
50:
MESSPFNRRQ | WTSLSLRVTA | KELSLVNKNK | SSAIVEIFSK | YQKAAEETNM |
100:
EKKRSNTENL | SQHFRKGTLT | VLKKKWENPG | LGAESHTDSL | RNSSTEIRHR |
150:
ADHPPAEVTS | HAASGAKADQ | EEQIHPRSRL | RSPPEALVQG | RYPHIKDGED |
200:
LKDHSTESKK | MENCLGESRH | EVEKSEISEN | TDASGKIEKY | NVPLNRLKMM |
250:
FEKGEPTQTK | ILRAQSRSAS | GRKISENSYS | LDDLEIGPGQ | LSSSTFDSEK |
300:
NESRRNLELP | RLSETSIKDR | MAKYQAAVSK | QSSSTNYTNE | LKASGGEIKI |
350:
HKMEQKENVP | PGPEVCITHQ | EGEKISANEN | SLAVRSTPAE | DDSRDSQVKS |
400:
EVQQPVHPKP | LSPDSRASSL | SESSPPKAMK | KFQAPARETC | VECQKTVYPM |
450:
ERLLANQQVF | HISCFRCSYC | NNKLSLGTYA | SLHGRIYCKP | HFNQLFKSKG |
500:
NYDEGFGHRP | HKDLWASKNE | NEEILERPAQ | LANARETPHS | PGVEDAPIAK |
550:
VGVLAASMEA | KASSQQEKED | KPAETKKLRI | AWPPPTELGS | SGSALEEGIK |
600:
MSKPKWPPED | EISKPEVPED | VDLDLKKLRR | SSSLKERSRP | FTVAASFQST |
650:
SVKSPKTVSP | PIRKGWSMSE | QSEESVGGRV | AERKQVENAK | ASKKNGNVGK |
700:
TTWQNKESKG | ETGKRSKEGH | SLEMENENLV | ENGADSDEDD | NSFLKQQSPQ |
750:
EPKSLNWSSF | VDNTFAEEFT | TQNQKSQDVE | LWEGEVVKEL | SVEEQIKRNR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
ELISA Kit for Human LIM domain and actin-binding protein 1
ELISA Kit for Human LIM domain and actin-binding protein 1
ELISA Kit for Human LIM domain and actin-binding protein 1
CLIA Kit for Human LIM domain and actin-binding protein 1
CLIA Kit for Human LIM domain and actin-binding protein 1
CLIA Kit for Human LIM domain and actin-binding protein 1
Polyclonal Antibody for Human LIM domain and actin-binding protein 1
Polyclonal Antibody for Human LIM domain and actin-binding protein 1
Polyclonal Antibody for Human LIM domain and actin-binding protein 1
Monoclonal Antibody for Human LIM domain and actin-binding protein 1
Monoclonal Antibody for Human LIM domain and actin-binding protein 1
Monoclonal Antibody for Human LIM domain and actin-binding protein 1
Protein for Human LIM domain and actin-binding protein 1
Protein for Human LIM domain and actin-binding protein 1
Protein for Human LIM domain and actin-binding protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA);SUBCELLULAR LOCATION
tissue :
Cervix carcinoma .
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
tissue :
Hypothalamus .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
tissue :
Uterus .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA; BETA AND 3)
tissue :
Colon .
tissue :
Hepatoma .
tissue :
Placenta .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue :
Brain .
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
tissue :
Brain .
tissue :
Cervix .
tissue :
Colon .
tissue :
Placenta .
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more...
Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-759
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE PROMOTER USAGE;INDUCTION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-490; SER-686 AND SER-692;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-362 AND SER-490;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Platelet .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490; SER-686 AND SER-692;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-225; TYR-229; SER-362; SER-374; SER-490; SER-604; SER-609; SER-617; SER-686; SER-692 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-617 AND SER-686;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
19.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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Vermeulen M.
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Santamaria A.
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Kumar C.
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Miller M.L.
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Jensen L.J.
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Cox J.
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Jensen T.S.
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Brunak S.
,
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-132; SER-225; SER-263; SER-343; SER-362; SER-374; SER-490; SER-604; SER-686; SER-692 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-350; SER-362; SER-365; SER-369; SER-374; SER-490; SER-686; SER-698 AND SER-726;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
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Lasa M.
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Gazquez C.
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Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 381-460