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Index > Protein center > LIMA1(Gene name) > Human
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  • LIMA1 (Gene name),
  • LIM domain and actin-binding protein 1 (Protein name ),  LIMA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    LIMA1(PP624;EPLIN;SREBP3);
    Protein name:
    LIM domain and actin-binding protein 1;
    Alternative:
    Epithelial protein lost in neoplasm;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments.
    Subcellular Location:
    Cytoplasm Cell junction focal adhesion Cytoplasm cytoskeleton This cytoskeletal protein co-localizes with actin stress fibers and focal adhesion plaques.
    Protein Attributes:
    Sequence length:
    759
    Sequence:
    50:
    MESSPFNRRQ | WTSLSLRVTA | KELSLVNKNK | SSAIVEIFSK | YQKAAEETNM | 
    100:
    EKKRSNTENL | SQHFRKGTLT | VLKKKWENPG | LGAESHTDSL | RNSSTEIRHR | 
    150:
    ADHPPAEVTS | HAASGAKADQ | EEQIHPRSRL | RSPPEALVQG | RYPHIKDGED | 
    200:
    LKDHSTESKK | MENCLGESRH | EVEKSEISEN | TDASGKIEKY | NVPLNRLKMM | 
    250:
    FEKGEPTQTK | ILRAQSRSAS | GRKISENSYS | LDDLEIGPGQ | LSSSTFDSEK | 
    300:
    NESRRNLELP | RLSETSIKDR | MAKYQAAVSK | QSSSTNYTNE | LKASGGEIKI | 
    350:
    HKMEQKENVP | PGPEVCITHQ | EGEKISANEN | SLAVRSTPAE | DDSRDSQVKS | 
    400:
    EVQQPVHPKP | LSPDSRASSL | SESSPPKAMK | KFQAPARETC | VECQKTVYPM | 
    450:
    ERLLANQQVF | HISCFRCSYC | NNKLSLGTYA | SLHGRIYCKP | HFNQLFKSKG | 
    500:
    NYDEGFGHRP | HKDLWASKNE | NEEILERPAQ | LANARETPHS | PGVEDAPIAK | 
    550:
    VGVLAASMEA | KASSQQEKED | KPAETKKLRI | AWPPPTELGS | SGSALEEGIK | 
    600:
    MSKPKWPPED | EISKPEVPED | VDLDLKKLRR | SSSLKERSRP | FTVAASFQST | 
    650:
    SVKSPKTVSP | PIRKGWSMSE | QSEESVGGRV | AERKQVENAK | ASKKNGNVGK | 
    700:
    TTWQNKESKG | ETGKRSKEGH | SLEMENENLV | ENGADSDEDD | NSFLKQQSPQ | 
    750:
    EPKSLNWSSF | VDNTFAEEFT | TQNQKSQDVE | LWEGEVVKEL | SVEEQIKRNR | 
    759:
    YYDEDEDEE
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    SMR:
    UniGene:
    KEGG:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human LIM domain and actin-binding protein 1
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    ELISA Kit for Human LIM domain and actin-binding protein 1
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    ELISA Kit for Human LIM domain and actin-binding protein 1
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    CLIA Kit for Human LIM domain and actin-binding protein 1
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    CLIA Kit for Human LIM domain and actin-binding protein 1
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    CLIA Kit for Human LIM domain and actin-binding protein 1
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    U14083m
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    Polyclonal Antibody for Human LIM domain and actin-binding protein 1
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    P14083Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LIM domain and actin-binding protein 1
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    P14083Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human LIM domain and actin-binding protein 1
    Monoclonal Antibody for Human LIM domain and actin-binding protein 1
    Monoclonal Antibody for Human LIM domain and actin-binding protein 1
    Monoclonal Antibody for Human LIM domain and actin-binding protein 1
    Protein for Human LIM domain and actin-binding protein 1
    Protein for Human LIM domain and actin-binding protein 1
    Protein for Human LIM domain and actin-binding protein 1

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    References
    1. 1.
      "EPLIN, epithelial protein lost in neoplasm."
      Maul R.S. , Chang D.D.
      Oncogene18:7838-7841(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA);SUBCELLULAR LOCATION
      tissue: Cervix carcinoma.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4)
      tissue: Hypothalamus.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
      tissue: Uterus.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA; BETA AND 3)
      tissue: Colon.
      tissue: Hepatoma.
      tissue: Placenta.
    5. 5.
      "Homo sapiens protein coding cDNA."
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Brain.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA)
      tissue: Brain.
      tissue: Cervix.
      tissue: Colon.
      tissue: Placenta.
    8. 8.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 232-759
    9. 9.
      "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing."
      Simpson J.C. , Wellenreuther R. , Poustka A. , Pepperkok R. , Wiemann S.
      EMBO Rep.1:287-292(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 10.
      "Characterization of the human EPLIN (Epithelial protein lost in neoplasm) gene reveals distinct promoters for the two EPLIN isoforms."
      Chen S. , Maul R.S. , Kim H.R. , Chang D.D.
      Gene248:69-76(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE PROMOTER USAGE;INDUCTION
    11. 11.
      "EPLIN regulates actin dynamics by cross-linking and stabilizing filaments."
      Maul R.S. , Song Y. , Amann K.J. , Gerbin S.C. , Pollard T.D. , Chang D.D.
      J. Cell Biol.160:399-407(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362; SER-490; SER-686 AND SER-692;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."
      Yu L.R. , Zhu Z. , Chan K.C. , Issaq H.J. , Dimitrov D.S. , Veenstra T.D.
      J. Proteome Res.6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-362 AND SER-490;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    15. 15.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-490; SER-686 AND SER-692;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-225; TYR-229; SER-362; SER-374; SER-490; SER-604; SER-609; SER-617; SER-686; SER-692 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604; SER-617 AND SER-686;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    19. 19.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-132; SER-225; SER-263; SER-343; SER-362; SER-374; SER-490; SER-604; SER-686; SER-692 AND SER-698;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-350; SER-362; SER-365; SER-369; SER-374; SER-490; SER-686; SER-698 AND SER-726;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Solution structure of the LIM domain of epithelial protein lost in neoplasm."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2006-06) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 381-460
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