Protein name:
Lipoprotein lipase (LPL) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1.
Function:
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Secreted
Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
Protein Attributes:
50:
MESKALLVLT | LAVWLQSLTA | SRGGVAAADQ | RRDFIDIESK | FALRTPEDTA |
100:
EDTCHLIPGV | AESVATCHFN | HSSKTFMVIH | GWTVTGMYES | WVPKLVAALY |
150:
KREPDSNVIV | VDWLSRAQEH | YPVSAGYTKL | VGQDVARFIN | WMEEEFNYPL |
200:
DNVHLLGYSL | GAHAAGIAGS | LTNKKVNRIT | GLDPAGPNFE | YAEAPSRLSP |
250:
DDADFVDVLH | TFTRGSPGRS | IGIQKPVGHV | DIYPNGGTFQ | PGCNIGEAIR |
300:
VIAERGLGDV | DQLVKCSHER | SIHLFIDSLL | NEENPSKAYR | CSSKEAFEKG |
350:
LCLSCRKNRC | NNLGYEINKV | RAKRSSKMYL | KTRSQMPYKV | FHYQVKIHFS |
400:
GTESETHTNQ | AFEISLYGTV | AESENIPFTL | PEVSTNKTYS | FLIYTEVDIG |
450:
ELLMLKLKWK | SDSYFSWSDW | WSSPGFAIQK | IRVKAGETQK | KVIFCSREKV |
475:
SHLQKGKAPA | VFVKCHDKSL | NKKSG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Bovine
Chicken
Polyclonal Antibody for Human LPL
Polyclonal Antibody for Human LPL
Polyclonal Antibody for Human LPL
Polyclonal Antibody for Human LPL
Polyclonal Antibody for Human LPL
Polyclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
Monoclonal Antibody for Human LPL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Placenta .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-318
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Cerebellum .
7.
Mural R.J.
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Istrail S.
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Florea L.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT SER-318
tissue :
Brain .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 28-44
tissue :
Milk .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : HEPARIN-BINDING;CATALYTIC ACTIVITY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GPIHBP1
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-70
tissue :
Milk .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : 3D-STRUCTURE MODELING
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY THR-271
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY GLU-215
18.
"A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY GLU-215
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY THR-203
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS LPL DEFICIENCY THR-221 AND HIS-270
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY GLY-183
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY GLU-169
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY THR-221
24.
"Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency."
Gotoda T.
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Yamada N.
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Kawamura M.
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J. Clin. Invest.88:1856-1864(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS LPL DEFICIENCY GLU-231 AND HIS-270;CHARACTERIZATION OF VARIANTS LPL DEFICIENCY GLU-231 AND HIS-270
25.
"A mutation in the human lipoprotein lipase gene as the most common cause of familial chylomicronemia in French Canadians."
Ma Y.
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Ven Murthy M.R.
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Roederer G.
,
Monsalve M.V.
,
Clarke L.A.
,
Normand T.
,
Julien P.
,
Gagne C.
,
Lambert M.
,
Davignon J.
,
Lupien P.J.
,
Brunzell J.
,
Hayden M.R.
N. Engl. J. Med.324:1761-1766(1991)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY LEU-234
26.
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Cited for : VARIANT LPL DEFICIENCY ARG-113
27.
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Cited for : VARIANT LPL DEFICIENCY ARG-184
28.
"A missense mutation (Asp250-->Asn) in exon 6 of the human lipoprotein lipase gene causes chylomicronemia in patients of different ancestries."
Ma Y.
,
Wilson B.I.
,
Bijvoet S.
,
Henderson H.E.
,
Cramb E.
,
Roederer G.
,
Ven Murthy M.R.
,
Julien P.
,
Bakker H.D.
,
Kastelein J.J.
,
Brunzell J.D.
,
Hayden M.R.
Genomics13:649-653(1992)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY ASN-277
29.
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Cited for : VARIANTS LPL DEFICIENCY ASN-183; GLY-183 AND SER-243
30.
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Cited for : CHARACTERIZATION OF VARIANTS LPL DEFICIENCY ASN-183 AND GLY-183;MUTAGENESIS OF SER-159 AND HIS-268
31.
"Missense mutations in exon 5 of the human lipoprotein lipase gene. Inactivation correlates with loss of dimerization."
Hata A.
,
Ridinger D.N.
,
Sutherland S.D.
,
Emi M.
,
Kwong L.K.
,
Shuhua J.
,
Lubbers A.
,
Guy-Grand B.
,
Basdevant A.
,
Iverius P.H.
,
Wilson D.E.
,
Lalouel J.-M.
J. Biol. Chem.267:20132-20139(1992)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY GLU-222
32.
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Cited for : VARIANTS LPL DEFICIENCY GLU-215; HIS-270 AND ASN-277
33.
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Cited for : VARIANTS LPL DEFICIENCY ARG-113; ARG-163; GLU-215; THR-221 AND SER-232
34.
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Cited for : VARIANT LPL DEFICIENCY THR-361
35.
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Cited for : VARIANT LPL DEFICIENCY GLU-207
36.
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Cited for : VARIANT LPL DEFICIENCY CYS-199
37.
"Mutations in exon 3 of the lipoprotein lipase gene segregating in a family with hypertriglyceridemia, pancreatitis, and non-insulin-dependent diabetes."
Wilson D.E.
,
Hata A.
,
Kwong L.K.
,
Lingam A.
,
Shuhua J.
,
Ridinger D.N.
,
Yeager C.
,
Kaltenborn K.C.
,
Iverius P.-H.
,
Lalouel J.-M.
J. Clin. Invest.92:203-211(1993)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY SER-102
38.
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Cited for : VARIANT LPL DEFICIENCY SER-181
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LPL DEFICIENCY VAL-392
40.
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Cited for : VARIANT LPL DEFICIENCY SER-70;CHARACTERIZATION OF VARIANT LPL DEFICIENCY SER-70
41.
"Recurrent missense mutations at the first and second base of codon Arg243 in human lipoprotein lipase in patients of different ancestries."
Ma Y.
,
Liu M.-S.
,
Chitayat D.
,
Bruin T.
,
Beisiegel U.
,
Benlian P.
,
Foubert L.
,
De Gennes J.L.
,
Funke H.
,
Forsythe I.
,
Blaichman S.
,
Papanikolaou M.
,
Erkelens D.W.
,
Kastelein J.
,
Brunzell J.D.
,
Hayden M.R.
Hum. Mutat.3:52-58(1994)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS LPL DEFICIENCY HIS-270 AND CYS-270
42.
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Cited for : VARIANTS LPL DEFICIENCY LEU-96 AND GLU-215;CHARACTERIZATION OF VARIANT LPL DEFICIENCY LEU-96
43.
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Cited for : VARIANTS LPL DEFICIENCY CYS-199; ARG-279; THR-288 AND SER-318;CHARACTERIZATION OF VARIANTS LPL DEFICIENCY ARG-279 AND THR-288
44.
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Cited for : VARIANT LPL DEFICIENCY VAL-437
45.
"A lipoprotein lipase mutation (Asn291Ser) is associated with reduced HDL cholesterol levels in premature atherosclerosis."
Reymer P.W.A.
,
Gagne E.
,
Groenemeyer B.E.
,
Zhang H.
,
Forsyth I.
,
Jansen H.
,
Seidell J.C.
,
Kromhout D.
,
Lie K.E.
,
Kastelein J.J.
,
Hayden M.R.
Nat. Genet.10:28-34(1995)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY SER-318
46.
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Cited for : VARIANT LPL DEFICIENCY TYR-445;CHARACTERIZATION OF VARIANT LPL DEFICIENCY TYR-445
47.
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Cited for : VARIANT LPL DEFICIENCY SER-318;VARIANT ASN-36
48.
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Cited for : VARIANTS LPL DEFICIENCY ASN-277 AND LYS-437
49.
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Cited for : VARIANTS LPL DEFICIENCY GLY-190 AND GLU-215
50.
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Cited for : VARIANT LPL DEFICIENCY HIS-289;VARIANT ASN-36;CHARACTERIZATION OF VARIANT LPL DEFICIENCY HIS-289;CHARACTERIZATION OF VARIANT ASN-36
51.
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Cited for : VARIANTS LPL DEFICIENCY ALA-128; GLU-215; ARG-215; CYS-270; ASN-277 AND PRO-313
52.
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Cited for : VARIANT LPL DEFICIENCY ARG-286
53.
"Familial lipoprotein lipase (LPL) deficiency: a catalogue of LPL gene mutations identified in 20 patients from the UK, Sweden, and Italy."
Mailly F.
,
Palmen J.
,
Muller D.P.R.
,
Gibbs T.
,
Lloyd J.
,
Brunzell J.
,
Durrington P.
,
Mitropoulos K.
,
Betteridge J.
,
Watts G.
,
Lithell H.
,
Angelico F.
,
Humphries S.E.
,
Talmud P.J.
Hum. Mutat.10:465-473(1997)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS
54.
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Cited for : VARIANTS LPL DEFICIENCY ALA-128; HIS-183; GLU-215; ARG-215; LEU-234; CYS-270 AND ASN-277
55.
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Cited for : VARIANTS LPL DEFICIENCY THR-252 AND HIS-270
56.
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Cited for : VARIANT LPL DEFICIENCY LYS-448;CHARACTERIZATION OF VARIANT LPL DEFICIENCY LYS-448
57.
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Cited for : VARIANTS LPL DEFICIENCY GLU-215 AND GLY-286
58.
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Cited for : VARIANT LPL DEFICIENCY SER-318;VARIANTS ASN-36 AND THR-288
59.
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Cited for : VARIANT LPL DEFICIENCY SER-318;VARIANTS MET-370 AND ALA-379
60.
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.22:231-238(1999)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT THR-427
61.
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.23:373-373(1999)
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Cited for : ERRATUM
62.
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Cited for : VARIANT LPL DEFICIENCY LEU-297;CHARACTERIZATION OF VARIANT LPL DEFICIENCY LEU-297
63.
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Cited for : VARIANTS LPL DEFICIENCY ARG-132 AND GLU-231;CHARACTERIZATION OF VARIANTS LPL DEFICIENCY ARG-132 AND GLU-231
64.
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Cited for : VARIANT LPL DEFICIENCY TRP-266
65.
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Cited for : VARIANT LPL DEFICIENCY ASP-210;CHARACTERIZATION OF VARIANT LPL DEFICIENCY ASP-210
66.
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Cited for : VARIANT LPL DEFICIENCY VAL-181;CHARACTERIZATION OF VARIANT LPL DEFICIENCY VAL-181
67.
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Cited for : VARIANTS LPL DEFICIENCY THR-98; ILE-208; VAL-279; ARG-279; TYR-310; ARG-325 AND PHE-365;CHARACTERIZATION OF VARIANTS LPL DEFICIENCY THR-98; ILE-208; VAL-279; ARG-279; TYR-310; ARG-325 AND PHE-365
68.
"Novel LPL mutation (L303F) found in a patient associated with coronary artery disease and severe systemic atherosclerosis."
Saika Y.
,
Sakai N.
,
Takahashi M.
,
Maruyama T.
,
Kihara S.
,
Ouchi N.
,
Ishigami M.
,
Hiraoka H.
,
Nakamura T.
,
Yamashita S.
,
Matsuzawa Y.
Eur. J. Clin. Invest.33:216-222(2003)
[
PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : VARIANT LPL DEFICIENCY PHE-303;CHARACTERIZATION OF VARIANT LPL DEFICIENCY PHE-303
69.
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Cited for : VARIANT LPL DEFICIENCY SER-318;VARIANT ASN-36
70.
"Identification of the first Lebanese mutation in the LPL gene and description of a rapid detection method."
Abifadel M.
,
Jambart S.
,
Allard D.
,
Rabes J.-P.
,
Varret M.
,
Derre A.
,
Chouery E.
,
Salem N.
,
Junien C.
,
Aydenian H.
,
Boileau C.
Clin. Genet.65:158-161(2004)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LPL DEFICIENCY VAL-201
71.
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Cited for : VARIANTS LPL DEFICIENCY GLU-215 AND ARG-328
72.
"Mutations in Japanese subjects with primary hyperlipidemia -- results from the Research Committee of the Ministry of Health and Welfare of Japan since 1996."
The research committee on primary hyperlipidemia of the ministry of health and welfare of Japan
,
Maruyama T.
,
Yamashita S.
,
Matsuzawa Y.
,
Bujo H.
,
Takahashi K.
,
Saito Y.
,
Ishibashi S.
,
Ohashi K.
,
Shionoiri F.
,
Gotoda T.
,
Yamada N.
,
Kita T.
J. Atheroscler. Thromb.11:131-145(2004)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS LPL DEFICIENCY SER-70; ARG-132; VAL-181; GLU-215; THR-221; ARG-225; ALA-227; GLU-231; CYS-270; HIS-270; THR-288; LEU-297; ARG-305; PHE-330 AND THR-361
73.
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Cited for : VARIANTS LPL DEFICIENCY GLU-186; GLU-215 AND THR-221