Protein name:
Lipoprotein lipase (LPL) ;
Alternative:
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Homodimer (By similarity). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids. Interacts with GPIHBP1.
Function:
The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
Subcellular Location:
Cell membrane
Lipid-anchor
GPI-anchor
Secreted
Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
Protein Attributes:
50:
MESKALLLVA | LSVWLQSLIV | SREGLATADR | ISGGRDFTDI | ESKFALRTPE |
100:
DTVEDTCHLI | PGVTESVANC | HFNHSSKTFV | VIHGWTVTGM | YESWVPKLVA |
150:
ALYKREPDSN | VIVVDWLSRA | QQHYPISAGY | TKLVGQDVAT | FIDWMAVEFS |
200:
YPPNNVHLLG | YSLGAHAAGI | AGSLTKKKVN | RITGLDPAGP | NFEYAEAPSR |
250:
LSPDDADFVD | VLHTFTRGSP | GRSIGIQKPV | GHVDIYPNGG | TFQPGCNIGE |
300:
AIRVIAERGL | GDVDQLVKCS | HERSIHLFID | SLLNEENPSK | AYRCNSKEAF |
350:
EKGLCLSCRK | NRCNNLGYEI | NKVRAKRSSK | MYLKTRAQMP | YKVFHYQVKM |
400:
RFSGTESDTH | TNQAFEISLY | GTVAESENIP | FTLPEVSTNK | TYSFLIYTEV |
450:
DIGELLMLKL | KWVSDSYFSW | SNWWSSPGFA | IEKIRVKAGE | TQKKVIFCSR |
478:
EKKSHLQKGK | SSVVFVKCHD | KSLNRKSG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Bovine
Chicken
Polyclonal Antibody for Pig LPL
Polyclonal Antibody for Pig LPL
Polyclonal Antibody for Pig LPL
Polyclonal Antibody for Pig LPL
Polyclonal Antibody for Pig LPL
Polyclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
Monoclonal Antibody for Pig LPL
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Norwegian Landrace .
tissue :
Skeletal muscle .