MAP3K8 ELISA Kit for Human(Homo sapiens) | EIAab.comMAP3K8 ELISA Kit for Human(Homo sapiens)

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MAP3K8 (Gene name),

Mitogen-activated protein kinase kinase kinase 8 (Protein name ), M3K8_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MAP3K8(COT;ESTF);

Protein name:

Mitogen-activated protein kinase kinase kinase 8;

Alternative:

Proto-oncogene c-Cot;Cancer Osaka thyroid oncogene;Tumor progression locus 2(TPL-2);Serine/threonine-protein kinase cot;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms a ternary complex with NFKB1 and TNIP2.

Function:

Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

467

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

467:

LAGYFNLVRG | PPTLEYG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:1326

SMR:

P41279

MIM:

191195

STRING:

9606.ENSP00000263056

Pfam:

PF00069

UniGene:

Hs.432453

String:

P41279

Uniprot:

P41279

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ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8

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E10350h

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96T

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8

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E10350m

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96T

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8

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E10350r

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96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8

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U10350h

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96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8

Cat.:

U10350m

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MSDS:

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Packing:

96T

CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8

Cat.:

U10350r

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96T

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8

Cat.:

P10350Rb-r

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8

Protein for Human Mitogen-activated protein kinase kinase kinase 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Structure and transforming potential of the human cot oncogene encoding a putative protein kinase."
Miyoshi J. , Higashi T. , Mukai H. , Ohuchi T. , Kakunaga T.
Mol. Cell. Biol.11:4088-4096(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ONCOGENIC VARIANT
tissue: Hepatoma.
2.

"The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation."
Aoki M. , Sugimoto T. , Sumida S. , Hamada F. , Akiyama T. , Toyoshima K.
J. Biol. Chem.268:22723-22732(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION
3.

"Expression cDNA cloning of a serine kinase transforming gene."
Chan A.M. , Chedid M. , McGovern E.S. , Popescu N.C. , Miki T. , Aaronson S.A.
Oncogene8:1329-1333(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Bone.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Tongue.
5.

SeattleSNPs variation discovery resource
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
9.

"COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation."
Sanchez-Gongora E. , Lisbona C. , de Gregorio R. , Ballester A. , Calvo V. , Perez-Jurado L. , Alemany S.
J. Biol. Chem.275:31379-31386(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112
tissue: T-cell.
10.

"Identification and characterization of protein products of the cot oncogene with serine kinase activity."
Aoki M. , Akiyama T. , Miyoshi J. , Toyoshima K.
Oncogene6:1515-1519(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION
11.

"TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."
Belich M.P. , Salmeron A. , Johnston L.H. , Ley S.C.
Nature397:363-368(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKB1
12.

"p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells."
Velasco-Sampayo A. , Alemany S.
J. Immunol.166:6084-6090(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling."
Channavajhala P.L. , Wu L. , Cuozzo J.W. , Hall J.P. , Liu W. , Lin L.-L. , Zhang Y.
J. Biol. Chem.278:47089-47097(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KSR2
14.

"NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase."
Waterfield M.R. , Zhang M. , Norman L.P. , Sun S.C.
Mol. Cell11:685-694(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1
15.

"Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity."
Luciano B.S. , Hsu S. , Channavajhala P.L. , Lin L.L. , Cuozzo J.W.
J. Biol. Chem.279:52117-52123(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-290;INTERACTION WITH KSR2;MUTAGENESIS OF THR-290
16.

"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Lang V. , Symons A. , Watton S.J. , Janzen J. , Soneji Y. , Beinke S. , Howell S. , Ley S.C.
Mol. Cell. Biol.24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1 AND TNIP2
17.

"Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide."
Cho J. , Tsichlis P.N.
Proc. Natl. Acad. Sci. U.S.A.102:2350-2355(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-290
18.

"TRAF6 and Src kinase activity regulates Cot activation by IL-1."
Rodriguez C. , Pozo M. , Nieto E. , Fernandez M. , Alemany S.
Cell. Signal.18:1376-1385(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer."
Black T.M. , Andrews C.L. , Kilili G. , Ivan M. , Tsichlis P.N. , Vouros P.
J. Proteome Res.6:2269-2276(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-80; SER-400 AND SER-443
20.

"Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."
Watford W.T. , Hissong B.D. , Durant L.R. , Yamane H. , Muul L.M. , Kanno Y. , Tato C.M. , Ramos H.L. , Berger A.E. , Mielke L. , Pesu M. , Solomon B. , Frucht D.M. , Paul W.E. , Sher A. , Jankovic D. , Tsichlis P.N. , O'Shea J.J.
J. Exp. Med.205:2803-2812(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
21.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2."
Handoyo H. , Stafford M.J. , McManus E. , Baltzis D. , Peggie M. , Cohen P.
Biochem. J.424:109-118(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-62; THR-290 AND SER-400;MUTAGENESIS OF SER-62; LYS-167; ASP-270; THR-290 AND SER-400
23.

"Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis."
Jager J. , Gremeaux T. , Gonzalez T. , Bonnafous S. , Debard C. , Laville M. , Vidal H. , Tran A. , Gual P. , Le Marchand-Brustel Y. , Cormont M. , Tanti J.F.
Diabetes59:61-70(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
24.

"IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400."
Roget K. , Ben-Addi A. , Mambole-Dema A. , Gantke T. , Yang H.T. , Janzen J. , Morrice N. , Abbott D. , Ley S.C.
Mol. Cell. Biol.32:4684-4690(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-400

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