Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > MAP3K8(Gene name) > Human
  • Add your favorite
  • MAP3K8 (Gene name),
  • Mitogen-activated protein kinase kinase kinase 8 (Protein name ),  M3K8_HUMAN from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    MAP3K8(COT;ESTF);
    Protein name:
    Mitogen-activated protein kinase kinase kinase 8;
    Alternative:
    Proto-oncogene c-Cot;Cancer Osaka thyroid oncogene;Tumor progression locus 2(TPL-2);Serine/threonine-protein kinase cot;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a ternary complex with NFKB1 and TNIP2.
    Function:
    Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    467
    Sequence:
    50:
    MEYMSTGSDN | KEEIDLLIKH | LNVSDVIDIM | ENLYASEEPA | VYEPSLMTMC | 
    100:
    QDSNQNDERS | KSLLLSGQEV | PWLSSVRYGT | VEDLLAFANH | ISNTAKHFYG | 
    150:
    QRPQESGILL | NMVITPQNGR | YQIDSDVLLI | PWKLTYRNIG | SDFIPRGAFG | 
    200:
    KVYLAQDIKT | KKRMACKLIP | VDQFKPSDVE | IQACFRHENI | AELYGAVLWG | 
    250:
    ETVHLFMEAG | EGGSVLEKLE | SCGPMREFEI | IWVTKHVLKG | LDFLHSKKVI | 
    300:
    HHDIKPSNIV | FMSTKAVLVD | FGLSVQMTED | VYFPKDLRGT | EIYMSPEVIL | 
    350:
    CRGHSTKADI | YSLGATLIHM | QTGTPPWVKR | YPRSAYPSYL | YIIHKQAPPL | 
    400:
    EDIADDCSPG | MRELIEASLE | RNPNHRPRAA | DLLKHEALNP | PREDQPRCQS | 
    450:
    LDSALLERKR | LLSRKELELP | ENIADSSCTG | STEESEMLKR | QRSLYIDLGA | 
    467:
    LAGYFNLVRG | PPTLEYG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    MIM:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    E10350h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    E10350m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    E10350r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    U10350h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    U10350m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    U10350r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    P10350Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    P10350Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Cat.:
    P10350Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase 8
    Protein for Human Mitogen-activated protein kinase kinase kinase 8
    Protein for Human Mitogen-activated protein kinase kinase kinase 8
    Protein for Human Mitogen-activated protein kinase kinase kinase 8

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Structure and transforming potential of the human cot oncogene encoding a putative protein kinase."
      Miyoshi J. , Higashi T. , Mukai H. , Ohuchi T. , Kakunaga T.
      Mol. Cell. Biol.11:4088-4096(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ONCOGENIC VARIANT
      tissue: Hepatoma.
    2. 2.
      "The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative initiation of translation."
      Aoki M. , Sugimoto T. , Sumida S. , Hamada F. , Akiyama T. , Toyoshima K.
      J. Biol. Chem.268:22723-22732(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION
    3. 3.
      "Expression cDNA cloning of a serine kinase transforming gene."
      Chan A.M. , Chedid M. , McGovern E.S. , Popescu N.C. , Miki T. , Aaronson S.A.
      Oncogene8:1329-1333(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Bone.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Tongue.
    5. 5.
      SeattleSNPs variation discovery resource
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "COT kinase proto-oncogene expression in T cells: implication of the JNK/SAPK signal transduction pathway in COT promoter activation."
      Sanchez-Gongora E. , Lisbona C. , de Gregorio R. , Ballester A. , Calvo V. , Perez-Jurado L. , Alemany S.
      J. Biol. Chem.275:31379-31386(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-112
      tissue: T-cell.
    10. 10.
      "Identification and characterization of protein products of the cot oncogene with serine kinase activity."
      Aoki M. , Akiyama T. , Miyoshi J. , Toyoshima K.
      Oncogene6:1515-1519(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE INITIATION;FUNCTION;SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION
    11. 11.
      "TPL-2 kinase regulates the proteolysis of the NF-kappaB-inhibitory protein NF-kappaB1 p105."
      Belich M.P. , Salmeron A. , Johnston L.H. , Ley S.C.
      Nature397:363-368(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKB1
    12. 12.
      "p27kip protein levels and E2F activity are targets of Cot kinase during G1 phase progression in T cells."
      Velasco-Sampayo A. , Alemany S.
      J. Immunol.166:6084-6090(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    13. 13.
      "Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling."
      Channavajhala P.L. , Wu L. , Cuozzo J.W. , Hall J.P. , Liu W. , Lin L.-L. , Zhang Y.
      J. Biol. Chem.278:47089-47097(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KSR2
    14. 14.
      "NF-kappaB1/p105 regulates lipopolysaccharide-stimulated MAP kinase signaling by governing the stability and function of the Tpl2 kinase."
      Waterfield M.R. , Zhang M. , Norman L.P. , Sun S.C.
      Mol. Cell11:685-694(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1
    15. 15.
      "Phosphorylation of threonine 290 in the activation loop of Tpl2/Cot is necessary but not sufficient for kinase activity."
      Luciano B.S. , Hsu S. , Channavajhala P.L. , Lin L.L. , Cuozzo J.W.
      J. Biol. Chem.279:52117-52123(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-290;INTERACTION WITH KSR2;MUTAGENESIS OF THR-290
    16. 16.
      "ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
      Lang V. , Symons A. , Watton S.J. , Janzen J. , Soneji Y. , Beinke S. , Howell S. , Ley S.C.
      Mol. Cell. Biol.24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NFKB1 AND TNIP2
    17. 17.
      "Phosphorylation at Thr-290 regulates Tpl2 binding to NF-kappaB1/p105 and Tpl2 activation and degradation by lipopolysaccharide."
      Cho J. , Tsichlis P.N.
      Proc. Natl. Acad. Sci. U.S.A.102:2350-2355(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-290
    18. 18.
      "TRAF6 and Src kinase activity regulates Cot activation by IL-1."
      Rodriguez C. , Pozo M. , Nieto E. , Fernandez M. , Alemany S.
      Cell. Signal.18:1376-1385(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    19. 19.
      "Characterization of phosphorylation sites on Tpl2 using IMAC enrichment and a linear ion trap mass spectrometer."
      Black T.M. , Andrews C.L. , Kilili G. , Ivan M. , Tsichlis P.N. , Vouros P.
      J. Proteome Res.6:2269-2276(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-80; SER-400 AND SER-443
    20. 20.
      "Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii."
      Watford W.T. , Hissong B.D. , Durant L.R. , Yamane H. , Muul L.M. , Kanno Y. , Tato C.M. , Ramos H.L. , Berger A.E. , Mielke L. , Pesu M. , Solomon B. , Frucht D.M. , Paul W.E. , Sher A. , Jankovic D. , Tsichlis P.N. , O'Shea J.J.
      J. Exp. Med.205:2803-2812(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2."
      Handoyo H. , Stafford M.J. , McManus E. , Baltzis D. , Peggie M. , Cohen P.
      Biochem. J.424:109-118(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT SER-62; THR-290 AND SER-400;MUTAGENESIS OF SER-62; LYS-167; ASP-270; THR-290 AND SER-400
    23. 23.
      "Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis."
      Jager J. , Gremeaux T. , Gonzalez T. , Bonnafous S. , Debard C. , Laville M. , Vidal H. , Tran A. , Gual P. , Le Marchand-Brustel Y. , Cormont M. , Tanti J.F.
      Diabetes59:61-70(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    24. 24.
      "IkappaB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400."
      Roget K. , Ben-Addi A. , Mambole-Dema A. , Gantke T. , Yang H.T. , Janzen J. , Morrice N. , Abbott D. , Ley S.C.
      Mol. Cell. Biol.32:4684-4690(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-400
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a KSR2 Gdf5
    Top Searches
    Ubiquitin-protein ligase Ubiquitin ELISA metalloproteinase Tumor necrosis Asprosin TRAP1A Alpha
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    Twitter