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Index > Protein center > MED13(Gene name) > Human
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  • MED13 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 13 (Protein name ),  MED13_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MED13(ARC250;KIAA0593;THRAP1;TRAP240);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 13;
    Alternative:
    Vitamin D3 receptor-interacting protein complex component DRIP250(DRIP250);Thyroid hormone receptor-associated protein complex 240 kDa component(Trap240);Thyroid hormone receptor-associated protein 1;Activator-recruited cofactor 250 kDa component(ARC250);Mediator complex subunit 13;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    2174
    Sequence:
    50:
    MSASFVPNGA | SLEDCHCNLF | CLADLTGIKW | KKYVWQGPTS | APILFPVTEE | 
    100:
    DPILSSFSRC | LKADVLGVWR | RDQRPGRREL | WIFWWGEDPS | FADLIHHDLS | 
    150:
    EEEDGVWENG | LSYECRTLLF | KAVHNLLERC | LMNRNFVRIG | KWFVKPYEKD | 
    200:
    EKPINKSEHL | SCSFTFFLHG | DSNVCTSVEI | NQHQPVYLLS | EEHITLAQQS | 
    250:
    NSPFQVILCP | FGLNGTLTGQ | AFKMSDSATK | KLIGEWKQFY | PISCCLKEMS | 
    300:
    EEKQEDMDWE | DDSLAAVEVL | VAGVRMIYPA | CFVLVPQSDI | PTPSPVGSTH | 
    350:
    CSSSCLGVHQ | VPASTRDPAM | SSVTLTPPTS | PEEVQTVDPQ | SVQKWVKFSS | 
    400:
    VSDGFNSDST | SHHGGKIPRK | LANHVVDRVW | QECNMNRAQN | KRKYSASSGG | 
    450:
    LCEEATAAKV | ASWDFVEATQ | RTNCSCLRHK | NLKSRNAGQQ | GQAPSLGQQQ | 
    500:
    QILPKHKTNE | KQEKSEKPQK | RPLTPFHHRV | SVSDDVGMDA | DSASQRLVIS | 
    550:
    APDSQVRFSN | IRTNDVAKTP | QMHGTEMANS | PQPPPLSPHP | CDVVDEGVTK | 
    600:
    TPSTPQSQHF | YQMPTPDPLV | PSKPMEDRID | SLSQSFPPQY | QEAVEPTVYV | 
    650:
    GTAVNLEEDE | ANIAWKYYKF | PKKKDVEFLP | PQLPSDKFKD | DPVGPFGQES | 
    700:
    VTSVTELMVQ | CKKPLKVSDE | LVQQYQIKNQ | CLSAIASDAE | QEPKIDPYAF | 
    750:
    VEGDEEFLFP | DKKDRQNSER | EAGKKHKVED | GTSSVTVLSH | EEDAMSLFSP | 
    800:
    SIKQDAPRPT | SHARPPSTSL | IYDSDLAVSY | TDLDNLFNSD | EDELTPGSKK | 
    850:
    SANGSDDKAS | CKESKTGNLD | PLSCISTADL | HKMYPTPPSL | EQHIMGFSPM | 
    900:
    NMNNKEYGSM | DTTPGGTVLE | GNSSSIGAQF | KIEVDEGFCS | PKPSEIKDFS | 
    950:
    YVYKPENCQI | LVGCSMFAPL | KTLPSQYLPP | IKLPEECIYR | QSWTVGKLEL | 
    1000:
    LSSGPSMPFI | KEGDGSNMDQ | EYGTAYTPQT | HTSFGMPPSS | APPSNSGAGI | 
    1050:
    LPSPSTPRFP | TPRTPRTPRT | PRGAGGPASA | QGSVKYENSD | LYSPASTPST | 
    1100:
    CRPLNSVEPA | TVPSIPEAHS | LYVNLILSES | VMNLFKDCNF | DSCCICVCNM | 
    1150:
    NIKGADVGVY | IPDPTQEAQY | RCTCGFSAVM | NRKFGNNSGL | FLEDELDIIG | 
    1200:
    RNTDCGKEAE | KRFEALRATS | AEHVNGGLKE | SEKLSDDLIL | LLQDQCTNLF | 
    1250:
    SPFGAADQDP | FPKSGVISNW | VRVEERDCCN | DCYLALEHGR | QFMDNMSGGK | 
    1300:
    VDEALVKSSC | LHPWSKRNDV | SMQCSQDILR | MLLSLQPVLQ | DAIQKKRTVR | 
    1350:
    PWGVQGPLTW | QQFHKMAGRG | SYGTDESPEP | LPIPTFLLGY | DYDYLVLSPF | 
    1400:
    ALPYWERLML | EPYGSQRDIA | YVVLCPENEA | LLNGAKSFFR | DLTAIYESCR | 
    1450:
    LGQHRPVSRL | LTDGIMRVGS | TASKKLSEKL | VAEWFSQAAD | GNNEAFSKLK | 
    1500:
    LYAQVCRYDL | GPYLASLPLD | SSLLSQPNLV | APTSQSLITP | PQMTNTGNAN | 
    1550:
    TPSATLASAA | SSTMTVTSGV | AISTSVATAN | STLTTASTSS | SSSSNLNSGV | 
    1600:
    SSNKLPSFPP | FGSMNSNAAG | SMSTQANTVQ | SGQLGGQQTS | ALQTAGISGE | 
    1650:
    SSSLPTQPHP | DVSESTMDRD | KVGIPTDGDS | HAVTYPPAIV | VYIIDPFTYE | 
    1700:
    NTDESTNSSS | VWTLGLLRCF | LEMVQTLPPH | IKSTVSVQII | PCQYLLQPVK | 
    1750:
    HEDREIYPQH | LKSLAFSAFT | QCRRPLPTST | NVKTLTGFGP | GLAMETALRS | 
    1800:
    PDRPECIRLY | APPFILAPVK | DKQTELGETF | GEAGQKYNVL | FVGYCLSHDQ | 
    1850:
    RWILASCTDL | YGELLETCII | NIDVPNRARR | KKSSARKFGL | QKLWEWCLGL | 
    1900:
    VQMSSLPWRV | VIGRLGRIGH | GELKDWSCLL | SRRNLQSLSK | RLKDMCRMCG | 
    1950:
    ISAADSPSIL | SACLVAMEPQ | GSFVIMPDSV | STGSVFGRST | TLNMQTSQLN | 
    2000:
    TPQDTSCTHI | LVFPTSASVQ | VASATYTTEN | LDLAFNPNND | GADGMGIFDL | 
    2050:
    LDTGDDLDPD | IINILPASPT | GSPVHSPGSH | YPHGGDAGKG | QSTDRLLSTE | 
    2100:
    PHEEVPNILQ | QPLALGYFVS | TAKAGPLPDW | FWSACPQAQY | QCPLFLKASL | 
    2150:
    HLHVPSVQSD | ELLHSKHSHP | LDSNQTSDVL | RFVLEQYNAL | SWLTCDPATQ | 
    2174:
    DRRSCLPIHF | VVLNQLYNFI | MNML
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 13
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 13
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 13
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 13
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 13
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 13
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 13
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 13
    Protein for Human Mediator of RNA polymerase II transcription subunit 13
    Protein for Human Mediator of RNA polymerase II transcription subunit 13

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
      Ito M. , Yuan C.-X. , Malik S. , Gu W. , Fondell J.D. , Yamamura S. , Fu Z.-Y. , Zhang X. , Qin J. , Roeder R.G.
      Mol. Cell3:361-370(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 696-713;TISSUE SPECIFICITY;IDENTIFICATION IN TRAP COMPLEX
      tissue: Cervix carcinoma.
    2. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    4. 5.
      "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 170-2174
      tissue: Brain.
    5. 6.
      Ohara O. , Nagase T. , Ishikawa K.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    6. 7.
      "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
      Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
      Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1401-1408 AND 1358-1367;IDENTIFICATION IN ARC COMPLEX
      tissue: Cervix carcinoma.
    7. 8.
      "Composite co-activator ARC mediates chromatin-directed transcriptional activation."
      Naeaer A.M. , Beaurang P.A. , Zhou S. , Abraham S. , Solomon W.B. , Tjian R.
      Nature398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN ARC COMPLEX;PROTEIN SEQUENCE OF 1429-1438; 1772-1783 AND 2073-2084
    8. 9.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;INTERACTION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
    9. 10.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1; MED18; MED21; MED28; MED29 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
    10. 11.
      "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
      Baek H.J. , Kang Y.K. , Roeder R.G.
      J. Biol. Chem.281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MED1 AND MED10
    11. 12.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500 AND SER-1029;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504 AND SER-537;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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