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Index > Protein center > MED14(Gene name) > Human
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  • MED14 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 14 (Protein name ),  MED14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MED14(ARC150;CRSP2;CXorf4;DRIP150;EXLM1;RGR1;TRAP170);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 14;
    Alternative:
    Transcriptional coactivator CRSP150;Thyroid hormone receptor-associated protein complex 170 kDa component(Trap170);RGR1 homolog(hRGR1);Mediator complex subunit 14;Vitamin D3 receptor-interacting protein complex 150 kDa component(DRIP150);Activator-recruited cofactor 150 kDa component(ARC150);Cofactor required for Sp1 transcriptional activation subunit 2(CRSP complex subunit 2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GATA1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with AR, ESR1, SREBF1 and STAT2.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1454
    Sequence:
    50:
    MAPVQLENHQ | LVPPGGGGGG | SGGPPSAPAP | PPPGAAVAAA | AAAAASPGYR | 
    100:
    LSTLIEFLLH | RAYSELMVLT | DLLPRKSDVE | RKIEIVQFAS | RTRQLFVRLL | 
    150:
    ALVKWANNAG | KVEKCAMISS | FLDQQAILFV | DTADRLASLA | RDALVHARLP | 
    200:
    SFAIPYAIDV | LTTGSYPRLP | TCIRDKIIPP | DPITKIEKQA | TLHQLNQILR | 
    250:
    HRLVTTDLPP | QLANLTVANG | RVKFRVEGEF | EATLTVMGDD | PDVPWRLLKL | 
    300:
    EILVEDKETG | DGRALVHSMQ | ISFIHQLVQS | RLFADEKPLQ | DMYNCLHSFC | 
    350:
    LSLQLEVLHS | QTLMLIRERW | GDLVQVERYH | AGKCLSLSVW | NQQVLGRKTG | 
    400:
    TASVHKVTIK | IDENDVSKPL | QIFHDPPLPA | SDSKLVERAM | KIDHLSIEKL | 
    450:
    LIDSVHARAH | QKLQELKAIL | RGFNANENSS | IETALPALVV | PILEPCGNSE | 
    500:
    CLHIFVDLHS | GMFQLMLYGL | DQATLDDMEK | SVNDDMKRII | PWIQQLKFWL | 
    550:
    GQQRCKQSIK | HLPTISSETL | QLSNYSTHPI | GNLSKNKLFI | KLTRLPQYYI | 
    600:
    VVEMLEVPNK | PTQLSYKYYF | MSVNAADRED | SPAMALLLQQ | FKENIQDLVF | 
    650:
    RTKTGKQTRT | NAKRKLSDDP | CPVESKKTKR | AGEMCAFNKV | LAHFVAMCDT | 
    700:
    NMPFVGLRLE | LSNLEIPHQG | VQVEGDGFSH | AIRLLKIPPC | KGITEETQKA | 
    750:
    LDRSLLDCTF | RLQGRNNRTW | VAELVFANCP | LNGTSTREQG | PSRHVYLTYE | 
    800:
    NLLSEPVGGR | KVVEMFLNDW | NSIARLYECV | LEFARSLPDI | PAHLNIFSEV | 
    850:
    RVYNYRKLIL | CYGTTKGSSI | SIQWNSIHQK | FHISLGTVGP | NSGCSNCHNT | 
    900:
    ILHQLQEMFN | KTPNVVQLLQ | VLFDTQAPLN | AINKLPTVPM | LGLTQRTNTA | 
    950:
    YQCFSILPQS | STHIRLAFRN | MYCIDIYCRS | RGVVAIRDGA | YSLFDNSKLV | 
    1000:
    EGFYPAPGLK | TFLNMFVDSN | QDARRRSVNE | DDNPPSPIGG | DMMDSLISQL | 
    1050:
    QPPPQQQPFP | KQPGTSGAYP | LTSPPTSYHS | TVNQSPSMMH | TQSPGNLHAA | 
    1100:
    SSPSGALRAP | SPASFVPTPP | PSSHGISIGP | GASFASPHGT | LDPSSPYTMV | 
    1150:
    SPSGRAGNWP | GSPQVSGPSP | AARMPGMSPA | NPSLHSPVPD | ASHSPRAGTS | 
    1200:
    SQTMPTNMPP | PRKLPQRSWA | ASIPTILTHS | ALNILLLPSP | TPGLVPGLAG | 
    1250:
    SYLCSPLERF | LGSVIMRRHL | QRIIQQETLQ | LINSNEPGVI | MFKTDALKCR | 
    1300:
    VALSPKTNQT | LQLKVTPENA | GQWKPDELQV | LEKFFETRVA | GPPFKANTLI | 
    1350:
    AFTKLLGAPT | HILRDCVHIM | KLELFPDQAT | QLKWNVQFCL | TIPPSAPPIA | 
    1400:
    PPGTPAVVLK | SKMLFFLQLT | QKTSVPPQEP | VSIIVPIIYD | MASGTTQQAD | 
    1450:
    IPRQQNSSVA | APMMVSNILK | RFAEMNPPRQ | GECTIFAAVR | DLMANLTLPP | 
    1454:
    GGRP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 14
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 14
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 14
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 14
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 14
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 14
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 14
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 14
    Protein for Human Mediator of RNA polymerase II transcription subunit 14
    Protein for Human Mediator of RNA polymerase II transcription subunit 14

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Detection and isolation of a novel human gene located on Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional DNA mapping method."
      Yoshikawa H. , Fujiyama A. , Nakai K. , Inazawa J. , Matsubara K.
      Genomics49:237-246(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
      Ryu S. , Zhou S. , Ladurner A.G. , Tjian R.
      Nature397:446-450(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
      Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
      Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 250-263 AND 1106-1146;IDENTIFICATION IN ARC COMPLEX
      tissue: Cervix carcinoma.
    4. 4.
      "A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation."
      Gu W. , Malik S. , Ito M. , Yuan C.-X. , Fondell J.D. , Zhang X. , Martinez E. , Qin J. , Roeder R.G.
      Mol. Cell3:97-108(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SMCC COMPLEX
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    7. 7.
      "NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription."
      Sun X. , Zhang Y. , Cho H. , Rickert P. , Lees E. , Lane W.S. , Reinberg D.
      Mol. Cell2:213-222(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A FORM OF THE MEDIATOR COMPLEX
    8. 8.
      "Composite co-activator ARC mediates chromatin-directed transcriptional activation."
      Naeaer A.M. , Beaurang P.A. , Zhou S. , Abraham S. , Solomon W.B. , Tjian R.
      Nature398:828-832(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 4-13 AND 1256-1264;IDENTIFICATION IN ARC COMPLEX
    9. 9.
      "A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression."
      Wang Q. , Sharma D. , Ren Y. , Fondell J.D.
      J. Biol. Chem.277:42852-42858(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AR
    10. 10.
      "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
      Kang Y.K. , Guermah M. , Yuan C.-X. , Roeder R.G.
      Proc. Natl. Acad. Sci. U.S.A.99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;INTERACTION OF THE MEDIATOR COMPLEX WITH ESR1 AND ESR2
    11. 11.
      "Role of metazoan mediator proteins in interferon-responsive transcription."
      Lau J.F. , Nusinzon I. , Burakov D. , Freedman L.P. , Horvath C.M.
      Mol. Cell. Biol.23:620-628(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT2
    12. 12.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
    13. 13.
      "Selective coactivator interactions in gene activation by SREBP-1a and -1c."
      Toth J.I. , Datta S. , Athanikar J.N. , Freedman L.P. , Osborne T.F.
      Mol. Cell. Biol.24:8288-8300(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SREBF1
    14. 14.
      "DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs."
      Lee J.E. , Kim K. , Sacchettini J.C. , Smith C.V. , Safe S.
      J. Biol. Chem.280:8819-8830(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ESR1
    15. 15.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1 AND MED10;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
    16. 16.
      "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
      Baek H.J. , Kang Y.K. , Roeder R.G.
      J. Biol. Chem.281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MED1 AND MED10
    17. 17.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1128; SER-1136 AND SER-1144;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-617 AND SER-986;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1112; SER-1128 AND SER-1136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    21. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1112; SER-1119; SER-1128 AND SER-1136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1325
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