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Index > Protein center > MED16(Gene name) > Human
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  • MED16 (Gene name),
  • Mediator of RNA polymerase II transcription subunit 16 (Protein name ),  MED16_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MED16(DRIP92;THRAP5);
    Protein name:
    Mediator of RNA polymerase II transcription subunit 16;
    Alternative:
    Vitamin D3 receptor-interacting protein complex 92 kDa component(DRIP92);Thyroid hormone receptor-associated protein complex 95 kDa component(Trap95);Mediator complex subunit 16;Thyroid hormone receptor-associated protein 5;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.
    Function:
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    877
    Sequence:
    50:
    MCDLRRPAAG | GMMDLAYVCE | WEKWSKSTHC | PSVPLACAWS | CRNLIAFTMD | 
    100:
    LRSDDQDLTR | MIHILDTEHP | WDLHSIPSEH | HEAITCLEWD | QSGSRLLSAD | 
    150:
    ADGQIKCWSM | ADHLANSWES | SVGSLVEGDP | IVALSWLHNG | VKLALHVEKS | 
    200:
    GASSFGEKFS | RVKFSPSLTL | FGGKPMEGWI | AVTVSGLVTV | SLLKPSGQVL | 
    250:
    TSTESLCRLR | GRVALADIAF | TGGGNIVVAT | ADGSSASPVQ | FYKVCVSVVS | 
    300:
    EKCRIDTEIL | PSLFMRCTTD | LNRKDKFPAI | THLKFLARDM | SEQVLLCASS | 
    350:
    QTSSIVECWS | LRKEGLPVNN | IFQQISPVVG | DKQPTILKWR | ILSATNDLDR | 
    400:
    VSAVALPKLP | ISLTNTDLKV | ASDTQFYPGL | GLALAFHDGS | VHIVHRLSLQ | 
    450:
    TMAVFYSSAA | PRPVDEPAMK | RPRTAGPAVH | LKAMQLSWTS | LALVGIDSHG | 
    500:
    KLSVLRLSPS | MGHPLEVGLA | LRHLLFLLEY | CMVTGYDWWD | ILLHVQPSMV | 
    550:
    QSLVEKLHEE | YTRQTAALQQ | VLSTRILAMK | ASLCKLSPCT | VTRVCDYHTK | 
    600:
    LFLIAISSTL | KSLLRPHFLN | TPDKSPGDRL | TEICTKITDV | DIDKVMINLK | 
    650:
    TEEFVLDMNT | LQALQQLLQW | VGDFVLYLLA | SLPNQGSLLR | PGHSFLRDGT | 
    700:
    SLGMLRELMV | VIRIWGLLKP | SCLPVYTATS | DTQDSMSLLF | RLLTKLWICC | 
    750:
    RDEGPASEPD | EALVDECCLL | PSQLLIPSLD | WLPASDGLVS | RLQPKQPLRL | 
    800:
    QFGRAPTLPG | SAATLQLDGL | ARAPGQPKID | HLRRLHLGAC | PTEECKACTR | 
    850:
    CGCVTMLKSP | NRTTAVKQWE | QRWIKNCLAV | EGRGPDACVT | SRASEEAPAF | 
    877:
    VQLGPQSTHH | SPRTPRSLDH | LHPEDRP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 16
    ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 16
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 16
    CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 16
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 16
    Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 16
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 16
    Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 16
    Protein for Human Mediator of RNA polymerase II transcription subunit 16
    Protein for Human Mediator of RNA polymerase II transcription subunit 16

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
      Ito M. , Yuan C.-X. , Malik S. , Gu W. , Fondell J.D. , Yamamura S. , Fu Z.-Y. , Zhang X. , Qin J. , Roeder R.G.
      Mol. Cell3:361-370(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 277-283;IDENTIFICATION IN TRAP COMPLEX;FUNCTION OF TRAP COMPLEX
      tissue: Cervix carcinoma.
    2. 2.
      "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
      Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
      Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);PROTEIN SEQUENCE OF 27-42 AND 755-772;IDENTIFICATION IN ARC COMPLEX;FUNCTION OF ARC COMPLEX
      tissue: B-cell.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 248-877 (ISOFORM 4)
      tissue: Skin.
      tissue: Uterus.
    4. 4.
      "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
      Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
      Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
    5. 5.
      "MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
      Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
      Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1; MED10; MED21 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
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