MED23 ELISA Kit for Human(Homo sapiens) | EIAab.comMED23 ELISA Kit for Human(Homo sapiens) | EIAab.com

Language:

[Sign in] [Register]

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > MED23(Gene name) > Human

Add your favorite

MED23 (Gene name),

Mediator of RNA polymerase II transcription subunit 23 (Protein name ), MED23_HUMAN from NCBI database.

top

Come back to page head.

|

General Annotation

|

Antigen Annotation

|

3D

|

Predicted Eptitope

|

Vaild Sequence

|

Related Databases

|

Feedback

Gene name:

MED23(ARC130;CRSP3;DRIP130;KIAA1216;SUR2);

Protein name:

Mediator of RNA polymerase II transcription subunit 23;

Alternative:

Cofactor required for Sp1 transcriptional activation subunit 3(CRSP complex subunit 3);Activator-recruited cofactor 130 kDa component(ARC130);Protein sur-2 homolog(hSur-2);Mediator complex subunit 23;Vitamin D3 receptor-interacting protein complex 130 kDa component(DRIP130);Transcriptional coactivator CRSP130;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ELK1 (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CEBPB, CTNNB1, and GLI3. Interacts with the adenovirus E1A protein.

Function:

Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1368

Sequence:

50:

METQLQSIFE | EVVKTEVIEE | AFPGMFMDTP | EDEKTKLISC | LGAFRQFWGG |

100:

LSQESHEQCI | QWIVKFIHGQ | HSPKRISFLY | DCLAMAVETG | LLPPRLVCES |

150:

LINSDTLEWE | RTQLWALTFK | LVRKIIGGVD | YKGVRDLLKV | ILEKILTIPN |

200:

TVSSAVVQQL | LAAREVIAYI | LERNACLLPA | YFAVTEIRKL | YPEGKLPHWL |

250:

LGNLVSDFVD | TFRPTARINS | ICGRCSLLPV | VNNSGAICNS | WKLDPATLRF |

300:

PLKGLLPYDK | DLFEPQTALL | RYVLEQPYSR | DMVCNMLGLN | KQHKQRCPVL |

350:

EDQLVDLVVY | AMERSETEEK | FDDGGTSQLL | WQHLSSQLIF | FVLFQFASFP |

400:

HMVLSLHQKL | AGRGLIKGRD | HLMWVLLQFI | SGSIQKNALA | DFLPVMKLFD |

450:

LLYPEKEYIP | VPDINKPQST | HAFAMTCIWI | HLNRKAQNDN | SKLQIPIPHS |

500:

LRLHHEFLQQ | SLRNKSLQMN | DYKIALLCNA | YSTNSECFTL | PMGALVETIY |

550:

GNGIMRIPLP | GTNCMASGSI | TPLPMNLLDS | LTVHAKMSLI | HSIATRVIKL |

600:

AHAKSSVALA | PALVETYSRL | LVYMEIESLG | IKGFISQLLP | TVFKSHAWGI |

650:

LHTLLEMFSY | RMHHIQPHYR | VQLLSHLHTL | AAVAQTNQNQ | LHLCVESTAL |

700:

RLITALGSSE | VQPQFTRFLS | DPKTVLSAES | EELNRALILT | LARATHVTDF |

750:

FTGSDSIQGT | WCKDILQTIM | SFTPHNWASH | TLSCFPGPLQ | AFFKQNNVPQ |

800:

ESRFNLKKNV | EEEYRKWKSM | SNENDIITHF | SMQGSPPLFL | CLLWKMLLET |

850:

DHINQIGYRV | LERIGARALV | AHVRTFADFL | VYEFSTSAGG | QQLNKCIEIL |

900:

NDMVWKYNIV | TLDRLILCLA | MRSHEGNEAQ | VCYFIIQLLL | LKPNDFRNRV |

950:

SDFVKENSPE | HWLQNDWHTK | HMNYHKKYPE | KLYFEGLAEQ | VDPPVQIQSP |

1000:

YLPIYFGNVC | LRFLPVFDIV | IHRFLELLPV | SKSLETLLDH | LGGLYKFHDR |

1050:

PVTYLYNTLH | YYEMHLRDRA | FLKRKLVHAI | IGSLKDNRPQ | GWCLSDTYLK |

1100:

CAMNAREENP | WVPDDTYYCR | LIGRLVDTMA | GKSPGPFPNC | DWRFNEFPNP |

1150:

AAHALHVTCV | ELMALAVSGK | EVGNALLNVV | LKSQPLVPRE | NITAWMNAIG |

1200:

LIITALPEPY | WIVLHDRIVS | VISSPSLTSE | TEWVGYPFRL | FDFTACHQSY |

1250:

SEMSCSYTLA | LAHAVWHHSS | IGQLSLIPKF | LTEVLLPIVK | TEFQLLYVYH |

1300:

LVGPFLQRFQ | QERTRCMIEI | GVAFYDMLLN | VDQCSTHLNY | MDPICDFLYH |

1350:

MKYMFTGDSV | KEQVEKIICN | LKPALKLRLR | FITHISKMEP | AAVPPQAMNS |

1368:

GSPAPQSNQV | PVSLPVTQ

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

MIM:

UniGene:

Pfam:

KEGG:

Uniprot:

FOR

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 23

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 23

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 23

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 23

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 23

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 23

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 23

Protein for Human Mediator of RNA polymerase II transcription subunit 23

Protein for Human Mediator of RNA polymerase II transcription subunit 23

Protein for Human Mediator of RNA polymerase II transcription subunit 23

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 254-280; 1317-1326 AND 1331-1337;IDENTIFICATION IN ARC COMPLEX
tissue: Cervix carcinoma.
2.

"Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein."
Boyer T.G. , Martin M.E.D. , Lees E. , Ricciardi R.P. , Berk A.J.
Nature399:276-279(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);FUNCTION;INTERACTION WITH E1A AND CDK8
3.

"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
Ryu S. , Zhou S. , Ladurner A.G. , Tjian R.
Nature397:446-450(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);IDENTIFICATION IN THE CRSP COMPLEX
4.

"Alternative splicing as a prevalent mechanism in regulating mammalian mediator tail subcomplex activity."
Kivil A. , Kazantseva A. , Vinkel K.J.M. , Sadam H. , Neuman T. , Palm K.
Submitted (2008-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6)
5.

"Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Kikuno R. , Hirosawa M. , Nomura N. , Ohara O.
DNA Res.6:337-345(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
6.

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S. , Weil B. , Wellenreuther R. , Gassenhuber J. , Glassl S. , Ansorge W. , Boecher M. , Bloecker H. , Bauersachs S. , Blum H. , Lauber J. , Duesterhoeft A. , Beyer A. , Koehrer K. , Strack N. , Mewes H.-W. , Ottenwaelder B. , Obermaier B. , more...
Genome Res.11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Testis.
7.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Placenta.
10.

"Composite co-activator ARC mediates chromatin-directed transcriptional activation."
Naeaer A.M. , Beaurang P.A. , Zhou S. , Abraham S. , Solomon W.B. , Tjian R.
Nature398:828-832(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE ARC COMPLEX;PROTEIN SEQUENCE OF 465-473 AND 1302-1311
11.

"TFIIH is negatively regulated by cdk8-containing mediator complexes."
Akoulitchev S. , Chuikov S. , Reinberg D.
Nature407:102-106(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED6
12.

"The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro."
Kang Y.K. , Guermah M. , Yuan C.-X. , Roeder R.G.
Proc. Natl. Acad. Sci. U.S.A.99:2642-2647(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
13.

"Ras induces mediator complex exchange on C/EBP beta."
Mo X. , Kowenz-Leutz E. , Xu H. , Leutz A.
Mol. Cell13:241-250(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CEBPB
14.

"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
15.

"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1 AND MED10;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
16.

"Mediator modulates Gli3-dependent Sonic hedgehog signaling."
Zhou H. , Kim S. , Ishii S. , Boyer T.G.
Mol. Cell. Biol.26:8667-8682(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CDK8; CTNNB1 AND GLI3
17.

"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
Baek H.J. , Kang Y.K. , Roeder R.G.
J. Biol. Chem.281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MED1 AND MED10
18.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."
Hashimoto S. , Boissel S. , Zarhrate M. , Rio M. , Munnich A. , Egly J.M. , Colleaux L.
Science333:1161-1163(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MRT18 GLN-617;CHARACTERIZATION OF VARIANT MRT18 GLN-617

Product Feedback Wall

Hot Genes: Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5

Top Searches: Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Tumor necrosis Alpha Asprosin TRAP1A

Why choose EIAAB: Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more

Further Information: About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

Copyright & copy www.eiaab.com2006-2016 All Rights Reserved EIAab Email:eiaab@eiaab.com

鄂ICP备10015095号-1

鄂公网安备 42018502005535号