Protein name:
Macrophage migration inhibitory factor (MIF) ;
Alternative:
Glycosylation-inhibiting factor (GIF) ;Delayed early response protein 6 (DER6) ;5.3.3.12;L-dopachrome tautomerase ) ;L-dopachrome isomerase ;Phenylpyruvate tautomerase ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homotrimer. Interacts with BNIPL (By similarity). Interacts with the CD74 extracellular domain. Interacts with COPS5 and with the CXCR2 extracellular domain.
Function:
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity.
Subcellular Location:
Secreted
Cytoplasm
Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens.
Protein Attributes:
50:
MPMFIVNTNV | PRASVPEGFL | SELTQQLAQA | TGKPAQYIAV | HVVPDQLMTF |
100:
SGTNDPCALC | SLHSIGKIGG | AQNRNYSKLL | CGLLSDRLHI | SPDRVYINYY |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Bovine
Rat
Human
Mouse
Chicken
Polyclonal Antibody for Mouse MIF
Polyclonal Antibody for Mouse MIF
Polyclonal Antibody for Mouse MIF
Polyclonal Antibody for Mouse MIF
Polyclonal Antibody for Mouse MIF
Polyclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
Monoclonal Antibody for Mouse MIF
R&D Technical Data
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12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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Citations
[1].
B Mathew, JR Jacobson, JH Siegler, et al.
[2].
DA White, L Fang, W Chan, et al.
[3].
H Sun, XJ Zhang, L Zhao, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 2-28
tissue :
Pituitary .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/Sv .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/Sv .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/Sv .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Kidney .
tissue :
Mammary gland .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-12;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Hippocampus .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 6-115
tissue :
Lens .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;ROLE OF TAUTOMERASE INHIBITORS IN IMPROVED SURVIVAL IN CASE OF SEPSIS
12.
"A tautomerase-null macrophage migration-inhibitory factor (MIF) gene knock-in mouse model reveals that protein interactions and not enzymatic activity mediate MIF-dependent growth regulation."
Fingerle-Rowson G.
,
Kaleswarapu D.R.
,
Schlander C.
,
Kabgani N.
,
Brocks T.
,
Reinart N.
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Schuetz A.
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Lue H.
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Du X.
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Liu A.
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Xiong H.
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Chen Y.
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Nemajerova A.
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Hallek M.
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Bernhagen J.
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Leng L.
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Bucala R.
Mol. Cell. Biol.29:1922-1932(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CD74; CXCR2 AND COPS5;CATALYTIC ACTIVITY;MUTAGENESIS OF PRO-2
13.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-78;SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-78;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS);TAUTOMERASE ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;CLEAVAGE OF INITIATOR METHIONINE;MUTAGENESIS OF PRO-2
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH INHIBITOR;TAUTOMERASE ACTIVITY;IDENTIFICATION BY MASS SPECTROMETRY;SUBUNIT