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Index > Protein center > Mmp14(Gene name) > Mouse
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  • Mmp14 (Gene name),
  • Matrix metalloproteinase-14 (Protein name ),  MMP14_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Mmp14(Mtmmp);
    Protein name:
    Matrix metalloproteinase-14(MMP-14);
    Alternative:
    MT-MMP;MMP-X1;Membrane-type-1 matrix metalloproteinase(MT1-MMP;MT1MMP);Membrane-type matrix metalloproteinase 1(MT-MMP 1;MTMMP1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7.
    Subcellular Location:
    Membrane Single-pass type I membrane protein Extracellular side Melanosome
    Protein Attributes:
    Sequence length:
    582
    Sequence:
    50:
    MSPAPRPSRS | LLLPLLTLGT | ALASLGWAQG | SNFSPEAWLQ | QYGYLPPGDL | 
    100:
    RTHTQRSPQS | LSAAIAAMQK | FYGLQVTGKA | DLATMMAMRR | PRCGVPDKFG | 
    150:
    TEIKANVRRK | RYAIQGLKWQ | HNEITFCIQN | YTPKVGEYAT | FEAIRKAFRV | 
    200:
    WESATPLRFR | EVPYAYIREG | HEKQADIMIL | FAEGFHGDST | PFDGEGGFLA | 
    250:
    HAYFPGPNIG | GDTHFDSAEP | WTVQNEDLNG | NDIFLVAVHE | LGHALGLEHS | 
    300:
    NDPSAIMAPF | YQWMDTENFV | LPDDDRRGIQ | QLYGSKSGSP | TKMPPQPRTT | 
    350:
    SRPSVPDKPK | NPAYGPNICD | GNFDTVAMLR | GEMFVFKERW | FWRVRNNQVM | 
    400:
    DGYPMPIGQF | WRGLPASINT | AYERKDGKFV | FFKGDKHWVF | DEASLEPGYP | 
    450:
    KHIKELGRGL | PTDKIDAALF | WMPNGKTYFF | RGNKYYRFNE | EFRAVDSEYP | 
    500:
    KNIKVWEGIP | ESPRGSFMGS | DEVFTYFYKG | NKYWKFNNQK | LKVEPGYPKS | 
    550:
    ALRDWMGCPS | GGRPDEGTEE | ETEVIIIEVD | EEGSGAVSAA | AVVLPVLLLL | 
    582:
    LVLAVGLAVF | FFRRHGTPKR | LLYCQRSLLD | KV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    KEGG:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse MMP-14
    Cat.:
    E2056h
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    Packing:
    96T
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    ELISA Kit for Mouse MMP-14
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    E2056p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse MMP-14
    Cat.:
    E2056r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse MMP-14
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse MMP-14
    Cat.:
    E2056b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse MMP-14
    Cat.:
    E2056m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    Cat.:
    U2056b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    Cat.:
    U2056p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    Cat.:
    U2056h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    Cat.:
    U2056r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    Cat.:
    U2056m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse MMP-14
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Mouse MMP-14
    Cat.:
    P2056Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MMP-14
    Cat.:
    P2056Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse MMP-14
    Polyclonal Antibody for Mouse MMP-14
    Polyclonal Antibody for Mouse MMP-14
    Polyclonal Antibody for Mouse MMP-14
    Cat.:
    P2056Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse MMP-14
    Monoclonal Antibody for Mouse MMP-14
    Monoclonal Antibody for Mouse MMP-14
    Monoclonal Antibody for Mouse MMP-14
    Monoclonal Antibody for Mouse MMP-14
    Monoclonal Antibody for Mouse MMP-14
    Protein for Mouse MMP-14
    Protein for Mouse MMP-14
    Protein for Mouse MMP-14
    Protein for Mouse MMP-14
    Protein for Mouse MMP-14
    Protein for Mouse MMP-14

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    Precision
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    Linearity
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    References
    1. 1.
      "Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas."
      Okada A. , Bellocq J.-P. , Rouyer N. , Chenard M.P. , Rio M.C. , Chambon P. , Basset P.
      Proc. Natl. Acad. Sci. U.S.A.92:2730-2734(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Odaka A.
      Submitted (1999-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesis."
      Apte S.S. , Fukai N. , Beier D.R. , Olsen B.R.
      J. Biol. Chem.272:25511-25517(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Sv.
    4. 4.
      "Cloning of murine membrane-type-1-matrix metalloproteinase (MT-1-MMP) and its metanephric developmental regulation with respect to MMP-2 and its inhibitor."
      Ota K. , Stetler-Stevenson W.G. , Yang Q. , Kumar A. , Wada J. , Kashihara N. , Wallner E.I. , Kanwar Y.S.
      Kidney Int.54:131-142(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: CD-1.
      tissue: Kidney.
    5. 5.
      "Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice."
      Rozanov D.V. , Savinov A.Y. , Golubkov V.S. , Tomlinson S. , Strongin A.Y.
      Cancer Res.66:6258-6263(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: FVB/N.
    6. 6.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      strain: NOD.
      tissue: Bone marrow.
      tissue: Eye.
      tissue: Spinal cord.
      tissue: Thymus.
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover."
      Holmbeck K. , Bianco P. , Caterina J. , Yamada S. , Kromer M. , Kuznetsov S.A. , Mankani M. , Robey P.G. , Poole A.R. , Pidoux I. , Ward J.M. , Birkedal-Hansen H.
      Cell99:81-92(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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