Protein name:
Interstitial collagenase ;
Alternative:
Matrix metalloproteinase-1 (MMP-1) ;Fibroblast collagenase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with HIV-1 Tat.
Function:
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MHSFPPLLLL | LFWGVVSHSF | PATLETQEQD | VDLVQKYLEK | YYNLKNDGRQ |
100:
VEKRRNSGPV | VEKLKQMQEF | FGLKVTGKPD | AETLKVMKQP | RCGVPDVAQF |
150:
VLTEGNPRWE | QTHLTYRIEN | YTPDLPRADV | DHAIEKAFQL | WSNVTPLTFT |
200:
KVSEGQADIM | ISFVRGDHRD | NSPFDGPGGN | LAHAFQPGPG | IGGDAHFDED |
250:
ERWTNNFREY | NLHRVAAHEL | GHSLGLSHST | DIGALMYPSY | TFSGDVQLAQ |
300:
DDIDGIQAIY | GRSQNPVQPI | GPQTPKACDS | KLTFDAITTI | RGEVMFFKDR |
350:
FYMRTNPFYP | EVELNFISVF | WPQLPNGLEA | AYEFADRDEV | RFFKGNKYWA |
400:
VQGQNVLHGY | PKDIYSSFGF | PRTVKHIDAA | LSEENTGKTY | FFVANKYWRY |
450:
DEYKRSMDPG | YPKMIAHDFP | GIGHKVDAVF | MKDGFFYFFH | GTRQYKFDPK |
469:
TKRILTLQKA | NSWFNCRKN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Human
Rat
Rabbit
Pig
ELISA Kit for Human Interstitial collagenase
ELISA Kit for Human Interstitial collagenase
ELISA Kit for Human Interstitial collagenase
ELISA Kit for Human Interstitial collagenase
ELISA Kit for Human Interstitial collagenase
CLIA Kit for Human Interstitial collagenase
CLIA Kit for Human Interstitial collagenase
CLIA Kit for Human Interstitial collagenase
CLIA Kit for Human Interstitial collagenase
CLIA Kit for Human Interstitial collagenase
Polyclonal Antibody for Human Interstitial collagenase
Polyclonal Antibody for Human Interstitial collagenase
Polyclonal Antibody for Human Interstitial collagenase
Polyclonal Antibody for Human Interstitial collagenase
Polyclonal Antibody for Human Interstitial collagenase
Monoclonal Antibody for Human Interstitial collagenase
Monoclonal Antibody for Human Interstitial collagenase
Monoclonal Antibody for Human Interstitial collagenase
Monoclonal Antibody for Human Interstitial collagenase
Monoclonal Antibody for Human Interstitial collagenase
Protein for Human Interstitial collagenase
Protein for Human Interstitial collagenase
Protein for Human Interstitial collagenase
Protein for Human Interstitial collagenase
Protein for Human Interstitial collagenase
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
G Han, H Shao, X Zhu, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
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Submitted (1996-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
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Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-191; GLN-405 AND THR-406
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Ovary .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-70
tissue :
Synovial cell .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 100-112 AND 270-287
tissue :
Fibroblast .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SIMILARITY TO THERMOLYSIN TYPE PROTEASES
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-120
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Cited for : INTERACTION WITH HIV-1 TAT
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-360;MUTAGENESIS OF TYR-360
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 100-269
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 102-269
18.
"Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor."
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 102-269
19.
"1.56-A structure of mature truncated human fibroblast collagenase."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 101-269
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 101-269