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Index > Protein center > MMP2(Gene name) > Human
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  • MMP2 (Gene name),
  • 72 kDa type IV collagenase (Protein name ),  MMP2_HUMAN from NCBI database.
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  • Gene name:
    MMP2(CLG4A);
    Protein name:
    72 kDa type IV collagenase;
    Alternative:
    Gelatinase A;72 kDa gelatinase;TBE-1;Matrix metalloproteinase-2(MMP-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.
    Function:
    PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
    Subcellular Location:
    Secreted extracellular space extracellular matrix Membrane Nucleus Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
    Protein Attributes:
    Sequence length:
    660
    Sequence:
    50:
    MEALMARGAL | TGPLRALCLL | GCLLSHAAAA | PSPIIKFPGD | VAPKTDKELA | 
    100:
    VQYLNTFYGC | PKESCNLFVL | KDTLKKMQKF | FGLPQTGDLD | QNTIETMRKP | 
    150:
    RCGNPDVANY | NFFPRKPKWD | KNQITYRIIG | YTPDLDPETV | DDAFARAFQV | 
    200:
    WSDVTPLRFS | RIHDGEADIM | INFGRWEHGD | GYPFDGKDGL | LAHAFAPGTG | 
    250:
    VGGDSHFDDD | ELWTLGEGQV | VRVKYGNADG | EYCKFPFLFN | GKEYNSCTDT | 
    300:
    GRSDGFLWCS | TTYNFEKDGK | YGFCPHEALF | TMGGNAEGQP | CKFPFRFQGT | 
    350:
    SYDSCTTEGR | TDGYRWCGTT | EDYDRDKKYG | FCPETAMSTV | GGNSEGAPCV | 
    400:
    FPFTFLGNKY | ESCTSAGRSD | GKMWCATTAN | YDDDRKWGFC | PDQGYSLFLV | 
    450:
    AAHEFGHAMG | LEHSQDPGAL | MAPIYTYTKN | FRLSQDDIKG | IQELYGASPD | 
    500:
    IDLGTGPTPT | LGPVTPEICK | QDIVFDGIAQ | IRGEIFFFKD | RFIWRTVTPR | 
    550:
    DKPMGPLLVA | TFWPELPEKI | DAVYEAPQEE | KAVFFAGNEY | WIYSASTLER | 
    600:
    GYPKPLTSLG | LPPDVQRVDA | AFNWSKNKKT | YIFAGDKFWR | YNEVKKKMDP | 
    650:
    GFPKLIADAW | NAIPDNLDAV | VDLQGGGHSY | FFKGAYYLKL | ENQSLKSVKF | 
    660:
    GSIKSDWLGC | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    MIM:
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human 72 kDa type IV collagenase
    Cat.:
    E0100m
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    Packing:
    96T
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    ELISA Kit for Human 72 kDa type IV collagenase
    Cat.:
    E0100h
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    MSDS:
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    96T
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    ELISA Kit for Human 72 kDa type IV collagenase
    Cat.:
    E0100r
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    ELISA Kit for Human 72 kDa type IV collagenase
    MSDS:
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    ELISA Kit for Human 72 kDa type IV collagenase
    Cat.:
    E0100c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human 72 kDa type IV collagenase
    Cat.:
    E0100b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human 72 kDa type IV collagenase
    MSDS:
    Please sign in first.
    CLIA Kit for Human 72 kDa type IV collagenase
    Cat.:
    U0100r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human 72 kDa type IV collagenase
    Cat.:
    U0100h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human 72 kDa type IV collagenase
    Cat.:
    U0100m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human 72 kDa type IV collagenase
    Cat.:
    U0100b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human 72 kDa type IV collagenase
    Cat.:
    U0100c
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Cat.:
    P0100Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Cat.:
    P0100Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Polyclonal Antibody for Human 72 kDa type IV collagenase
    Cat.:
    P0100Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Monoclonal Antibody for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase
    Protein for Human 72 kDa type IV collagenase

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    Recovery
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    Linearity
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    References
    1. 1.
      "Structure of the human type IV collagenase gene."
      Huhtala P. , Chow L.T. , Tryggvason K.
      J. Biol. Chem.265:11077-11082(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes."
      Collier I.E. , Bruns G.A.P. , Goldberg G.I. , Gerhard D.S.
      Genomics9:429-434(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Teratocarcinoma.
      tissue: Testis.
    4. 4.
      NIEHS SNPs program
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-447 AND LEU-621
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "Completion of the primary structure of the human type IV collagenase preproenzyme and assignment of the gene (CLG4) to the q21 region of chromosome 16."
      Huhtala P. , Eddy R.L. , Fan Y.S. , Byers M.G. , Shows T.B. , Tryggvason K.
      Genomics6:554-559(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51
    8. 8.
      "H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen."
      Collier I.E. , Wilhelm S.M. , Eisen A.Z. , Marmer B.L. , Grant G.A. , Seltzer J.L. , Kronberger A. , He C. , Bauer E.A. , Goldberg G.I.
      J. Biol. Chem.263:6579-6587(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-660 (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
    9. 9.
      "TIMP-2: identification and characterization of a new member of the metalloproteinase inhibitor family."
      Stetler-Stevenson W.G. , Krutzsch H.C. , Liotta L.A.
      Matrix Suppl.1:299-306(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 30-44
      tissue: Melanoma.
    10. 10.
      "Binding of tissue inhibitor of metalloproteinases 2 to two distinct sites on human 72-kDa gelatinase. Identification of a stabilization site."
      Howard E.W. , Banda M.J.
      J. Biol. Chem.266:17972-17977(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TIMP2
    11. 11.
      "Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3."
      Brooks P.C. , Stroemblad S. , Sanders L.C. , von Schalscha T.L. , Aimes R.T. , Stetler-Stevenson W.G. , Quigley J.P. , Cheresh D.A.
      Cell85:683-693(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF RECEPTOR;SUBCELLULAR LOCATION
    12. 12.
      "Membrane-type-2 matrix metalloproteinase can initiate the processing of progelatinase A and is regulated by the tissue inhibitors of metalloproteinases."
      Butler G.S. , Will H. , Atkinson S.J. , Murphy G.
      Eur. J. Biochem.244:653-657(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    13. 13.
      "Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity."
      Brooks P.C. , Silletti S. , von Schalscha T.L. , Friedlander M. , Cheresh D.A.
      Cell92:391-400(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF RECEPTOR;FUNCTION
    14. 14.
      "Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor."
      Fernandez-Patron C. , Radomski M.W. , Davidge S.T.
      Circ. Res.85:906-911(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "Vascular matrix metalloproteinase-2-dependent cleavage of calcitonin gene-related peptide promotes vasoconstriction."
      Fernandez-Patron C. , Stewart K.G. , Zhang Y. , Koivunen E. , Radomski M.W. , Davidge S.T.
      Circ. Res.87:670-676(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    16. 16.
      "Simultaneous inhibition of glioma angiogenesis, cell proliferation, and invasion by a naturally occurring fragment of human metalloproteinase-2."
      Bello L. , Lucini V. , Carrabba G. , Giussani C. , Machluf M. , Pluderi M. , Nikas D. , Zhang J. , Tomei G. , Villani R.M. , Carroll R.S. , Bikfalvi A. , Black P.M.
      Cancer Res.61:8730-8736(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF PEX;TISSUE SPECIFICITY;INTERACTION WITH TIMP2
    17. 17.
      "Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontal disease."
      Gusman H. , Travis J. , Helmerhorst E.J. , Potempa J. , Troxler R.F. , Oppenheim F.G.
      Infect. Immun.69:1402-1408(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    18. 18.
      "Human cervical tumor cell (SiHa) surface alphavbeta3 integrin receptor has associated matrix metalloproteinase (MMP-2) activity."
      Chattopadhyay N. , Mitra A. , Frei E. , Chatterjee A.
      J. Cancer Res. Clin. Oncol.127:653-658(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF RECEPTOR;INTERACTION WITH TMP2;FUNCTION
    19. 19.
      "Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy."
      Noda K. , Ishida S. , Inoue M. , Obata K. , Oguchi Y. , Okada Y. , Ikeda E.
      Invest. Ophthalmol. Vis. Sci.44:2163-2170(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THE FORMATION OF THE FIBROVASCULAR TISSUES
    20. 20.
      "Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases."
      Takino T. , Koshikawa N. , Miyamori H. , Tanaka M. , Sasaki T. , Okada Y. , Seiki M. , Sato H.
      Oncogene22:4617-4626(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING OF KISS1
    21. 21.
      "Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro."
      Kwan J.A. , Schulze C.J. , Wang W. , Leon H. , Sariahmetoglu M. , Sung M. , Sawicka J. , Sims D.E. , Sawicki G. , Schulz R.
      FASEB J.18:690-692(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    22. 22.
      "Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation."
      Sariahmetoglu M. , Crawford B.D. , Leon H. , Sawicka J. , Li L. , Ballermann B.J. , Holmes C. , Berthiaume L.G. , Holt A. , Sawicki G. , Schulz R.
      FASEB J.21:2486-2495(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;IDENTIFICATION BY MASS SPECTROMETRY
    23. 23.
      "Glycogen synthase kinase-3beta is activated by matrix metalloproteinase-2 mediated proteolysis in cardiomyoblasts."
      Kandasamy A.D. , Schulz R.
      Cardiovasc. Res.83:698-706(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSK3B;FUNCTION
    24. 24.
      "Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes."
      Hua Y. , Xue J. , Sun F. , Zhu L. , Xie M.
      Pharmacology83:18-25(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    25. 25.
      "A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity."
      Lovett D.H. , Mahimkar R. , Raffai R.L. , Cape L. , Maklashina E. , Cecchini G. , Karliner J.S.
      PLoS ONE7:E34177-E34177(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION
    26. 26.
      "Crystal structure of the haemopexin-like C-terminal domain of gelatinase A."
      Libson A.M. , Gittis A.G. , Collier I.E. , Marmer B.L. , Goldberg G.I. , Lattman E.E.
      Nat. Struct. Biol.2:938-942(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 443-660
    27. 27.
      "The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function."
      Gohlke U. , Gomis-Rueth F.-X. , Crabbe T. , Murphy G. , Docherty A.J. , Bode W.
      FEBS Lett.378:126-130(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 458-660
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      "Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed."
      Morgunova E. , Tuuttila A. , Bergmann U. , Isupov M. , Lindqvist Y. , Schneider G. , Tryggvason K.
      Science284:1667-1670(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 30-660 OF MUTANT ALA-404
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      "The second type II module from human matrix metalloproteinase 2: structure, function and dynamics."
      Briknarova K. , Grishaev A. , Banyai L. , Tordai H. , Patthy L. , Llinas M.
      Structure7:1235-1245(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 278-336;DISULFIDE BONDS
    30. 30.
      "Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct."
      Briknarova K. , Gehrmann M. , Banyai L. , Tordai H. , Patthy L. , Llinas M.
      J. Biol. Chem.276:27613-27621(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 337-394 OF WILD TYPE AND IN COMPLEX WITH PPG PEPTIDES
    31. 31.
      "Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor."
      Feng Y. , Likos J.J. , Zhu L. , Woodward H. , Munie G. , McDonald J.J. , Stevens A.M. , Howard C.P. , De Crescenzo G.A. , Welsch D. , Shieh H.S. , Stallings W.C.
      Biochim. Biophys. Acta1598:10-23(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 110-446 IN COMPLEX WITH A HYDROXAMIC ACID INHIBITOR
    32. 32.
      "The col-1 module of human matrix metalloproteinase-2 (MMP-2): structural/functional relatedness between gelatin-binding fibronectin type II modules and lysine-binding kringle domains."
      Gehrmann M. , Briknarova K. , Banyai L. , Patthy L. , Llinas M.
      Biol. Chem.383:137-148(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 223-282 OF WILD TYPE AND IN COMPLEX WITH A PPG PEPTIDE
    33. 33.
      "Structural insight into the complex formation of latent matrix metalloproteinase 2 with tissue inhibitor of metalloproteinase 2."
      Morgunova E. , Tuuttila A. , Bergmann U. , Tryggvason K.
      Proc. Natl. Acad. Sci. U.S.A.99:7414-7419(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 30-660 IN COMPLEX WITH INHIBITOR TIMP2
    34. 34.
      "Matrix metalloproteinase target family landscape: a chemometrical approach to ligand selectivity based on protein binding site analysis."
      Pirard B. , Matter H.
      J. Med. Chem.49:51-69(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 115-449
    35. 35.
      "Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome."
      Martignetti J.A. , Aqeel A.A. , Sewairi W.A. , Boumah C.E. , Kambouris M. , Mayouf S.A. , Sheth K.V. , Eid W.A. , Dowling O. , Harris J. , Glucksman M.J. , Bahabri S. , Meyer B.F. , Desnick R.J.
      Nat. Genet.28:261-265(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MONA HIS-101;VARIANT TYR-210
    36. 36.
      "Winchester syndrome caused by a homozygous mutation affecting the active site of matrix metalloproteinase 2."
      Zankl A. , Bonafe L. , Calcaterra V. , Di Rocco M. , Superti-Furga A.
      Clin. Genet.67:261-266(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MONA LYS-404
    37. 37.
      "A novel homozygous MMP2 mutation in a family with Winchester syndrome."
      Rouzier C. , Vanatka R. , Bannwarth S. , Philip N. , Coussement A. , Paquis-Flucklinger V. , Lambert J.-C.
      Clin. Genet.69:271-276(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MONA VAL-400 DEL
    38. 38.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] THR-228; MET-498 AND ILE-644
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