MTOR ELISA Kit for Human(Homo sapiens) | EIAab.comMTOR ELISA Kit for Human(Homo sapiens)

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MTOR (Gene name),

Serine/threonine-protein kinase mTOR (Protein name ), MTOR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MTOR(FRAP;FRAP1;FRAP2;RAFT1;RAPT1);

Protein name:

Serine/threonine-protein kinase mTOR;

Alternative:

FKBP12-rapamycin complex-associated protein;FK506-binding protein 12-rapamycin complex-associated protein 1;Mechanistic target of rapamycin;Mammalian target of rapamycin(mTOR);Rapamycin target protein 1;Rapamycin target protein 1(RAPT1);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PPAPDC3 and PML (By similarity). Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR/FRAP1, MLST8, RPTOR and AKT1S1. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PROTOR1, RICTOR and MAPKAP1. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PROTOR1 and RICTOR within the mTORC2 complex. Interacts with UBQLN1. Interacts with DEPTOR. Interacts with TTI1 and TELO2.

Function:

Kinase subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Phosphorylates MAF1 leading to attenuation of its RNA polymerase III-repressive function. mTORC2 is also activated by growth. factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-757', disrupting the interaction with AMPK and preventing activation of ULK1.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Cytoplasmic side Golgi apparatus membrane Peripheral membrane protein Cytoplasmic side Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side Lysosome Cytoplasm Nucleus PML body Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB.

Protein Attributes:

Sequence length:

2549

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INRVRDKLTG | RDFSHDDTLD | VPTQVELLIK | QATSHENLCQ | CYIGWCPFW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.338207

SMR:

P42345

STRING:

9606.ENSP00000354558

Pfam:

PF11865

KEGG:

hsa:2475

String:

P42345

MIM:

601231

Uniprot:

P42345

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ELISA Kit for Human Serine/threonine-protein kinase mTOR

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E14969h

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96T

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ELISA Kit for Human Serine/threonine-protein kinase mTOR

Cat.:

E14969r

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ELISA Kit for Human Serine/threonine-protein kinase mTOR

Cat.:

E14969m

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96T

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CLIA Kit for Human Serine/threonine-protein kinase mTOR

Cat.:

U14969h

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Packing:

96T

CLIA Kit for Human Serine/threonine-protein kinase mTOR

MSDS:

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CLIA Kit for Human Serine/threonine-protein kinase mTOR

Cat.:

U14969m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Serine/threonine-protein kinase mTOR

Monoclonal Antibody for Human Serine/threonine-protein kinase mTOR

Protein for Human Serine/threonine-protein kinase mTOR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"A mammalian protein targeted by G1-arresting rapamycin-receptor complex."
Brown E.J. , Albers M.W. , Shin T.B. , Ichikawa K. , Keith C.T. , Lane W.S. , Schreiber S.L.
Nature369:756-758(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
2.

"Molecular cloning and expression analysis of five novel genes in chromosome 1p36."
Onyango P. , Lubyova B. , Gardellin P. , Kurzbauer R. , Weith A.
Genomics50:187-198(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Cerebellum.
6.

"The human gene for mannan-binding lectin-associated serine protease-2 (MASP-2), the effector component of the lectin route of complement activation, is part of a tightly linked gene cluster on chromosome 1p36.2-3."
Stover C. , Endo Y. , Takahashi M. , Lynch N. , Constantinescu C. , Vorup-Jensen T. , Thiel S. , Friedl H. , Hankeln T. , Hall R. , Gregory S. , Fujita T. , Schwaeble W.
Genes Immun.2:119-127(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1362-2549
7.

"RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex."
Chiu M.I. , Katz H. , Berlin V.
Proc. Natl. Acad. Sci. U.S.A.91:12574-12578(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1987-2146;TISSUE SPECIFICITY
tissue: B-cell.
8.

"Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells."
Withers D.J. , Ouwens D.M. , Nave B.T. , van der Zon G.C.M. , Alarcon C.M. , Cardenas M.E. , Heitman J. , Maassen J.A. , Shepherd P.R.
Biochem. Biophys. Res. Commun.241:704-709(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;AUTOPHOSPHORYLATION
9.

"Characterization of ubiquilin 1, an mTOR-interacting protein."
Wu S. , Mikhailov A. , Kallo-Hosein H. , Hara K. , Yonezawa K. , Avruch J.
Biochim. Biophys. Acta1542:41-56(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBQLN1
10.

"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the growth machinery."
Kim D.-H. , Sarbassov D.D. , Ali S.M. , King J.E. , Latek R.R. , Erdjument-Bromage H. , Tempst P. , Sabatini D.M.
Cell110:163-175(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NUTRIENT-DEPENDENT CELL GROWTH;FUNCTION IN PHOSPHORYLATION OF RPS6KB1;INTERACTION WITH RPTOR
11.

"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action."
Hara K. , Maruki Y. , Long X. , Yoshino K. , Oshiro N. , Hidayat S. , Tokunaga C. , Avruch J. , Yonezawa K.
Cell110:177-189(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RPTOR
12.

"The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase."
Choi J.H. , Bertram P.G. , Drenan R. , Carvalho J. , Zhou H.H. , Zheng X.F.
EMBO Rep.3:988-994(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLIP1;FUNCTION IN PHOSPHORYLATION OF CLIP1
13.

"Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin."
Park I.H. , Bachmann R. , Shirazi H. , Chen J.
J. Biol. Chem.277:31423-31429(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF RPS6KB2
14.

"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control."
Loewith R. , Jacinto E. , Wullschleger S. , Lorberg A. , Crespo J.L. , Bonenfant D. , Oppliger W. , Jenoe P. , Hall M.N.
Mol. Cell10:457-468(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MLST8 AND RPTOR;IDENTIFICATION IN THE MTORC1 COMPLEX;TISSUE SPECIFICITY
15.

"FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction."
Desai B.N. , Myers B.R. , Schreiber S.L.
Proc. Natl. Acad. Sci. U.S.A.99:4319-4324(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
16.

"TSC2 mediates cellular energy response to control cell growth and survival."
Inoki K. , Zhu T. , Guan K.L.
Cell115:577-590(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;FUNCTION IN RESPONSE TO LOW CELLULAR ENERGY
17.

"GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR."
Kim D.-H. , Sarbassov D.D. , Ali S.M. , Latek R.R. , Guntur K.V.P. , Erdjument-Bromage H. , Tempst P. , Sabatini D.M.
Mol. Cell11:895-904(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MLST8
18.

"Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton."
Sarbassov D.D. , Ali S.M. , Kim D.-H. , Guertin D.A. , Latek R.R. , Erdjument-Bromage H. , Tempst P. , Sabatini D.M.
Curr. Biol.14:1296-1302(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF PRKCA;FUNCTION IN REGULATION OF THE ACTIN CYTOSKELETON;IDENTIFICATION IN THE MTORC2 COMPLEX;INTERACTION WITH RICTOR
19.

"Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex."
Brugarolas J. , Lei K. , Hurley R.L. , Manning B.D. , Reiling J.H. , Hafen E. , Witters L.A. , Ellisen L.W. , Kaelin W.G. Jr.
Genes Dev.18:2893-2904(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;FUNCTION IN RESPONSE TO HYPOXIA
20.

"FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus."
Drenan R.M. , Liu X. , Bertram P.G. , Zheng X.F.S.
J. Biol. Chem.279:772-778(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
21.

"Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive."
Jacinto E. , Loewith R. , Schmidt A. , Lin S. , Ruegg M.A. , Hall A. , Hall M.N.
Nat. Cell Biol.6:1122-1128(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF THE ACTIN CYTOSKELETON;FUNCTION IN PHOSPHORYLATION OF PXN;IDENTIFICATION IN THE MTORC2 COMPLEX;INTERACTION WITH RICTOR;AUTOPHOSPHORYLATION
22.

"Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase."
Holz M.K. , Blenis J.
J. Biol. Chem.280:26089-26093(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-2446 AND SER-2448
23.

"Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex."
Sarbassov D.D. , Guertin D.A. , Ali S.M. , Sabatini D.M.
Science307:1098-1101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF AKT1
24.

"PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling."
Woo S.-Y. , Kim D.-H. , Jun C.-B. , Kim Y.-M. , Haar E.V. , Lee S.-I. , Hegg J.W. , Bandhakavi S. , Griffin T.J. , Kim D.-H.
J. Biol. Chem.282:25604-25612(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MTORC2 COMPLEX;INTERACTION WITH PRR5
25.

"PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase."
Sancak Y. , Thoreen C.C. , Peterson T.R. , Lindquist R.A. , Kang S.A. , Spooner E. , Carr S.A. , Sabatini D.M.
Mol. Cell25:903-915(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AKT1S1;ENZYME REGULATION
26.

"mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)."
Garcia-Martinez J.M. , Alessi D.R.
Biochem. J.416:375-385(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MTORC1 AND MTORC2 COMPLEXES;FUNCTION IN PHOSPHORYLATION OF RPS6KB1 AND SGK1
27.

"SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth."
Porstmann T. , Santos C.R. , Griffiths B. , Cully M. , Wu M. , Leevers S. , Griffiths J.R. , Chung Y.L. , Schulze A.
Cell Metab.8:224-236(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN LIPID SYNTHESIS AND CELL GROWTH
28.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
29.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2478 AND SER-2481;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
30.

"The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1."
Sancak Y. , Peterson T.R. , Shaul Y.D. , Lindquist R.A. , Thoreen C.C. , Bar-Peled L. , Sabatini D.M.
Science320:1496-1501(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION
31.

"DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival."
Peterson T.R. , Laplante M. , Thoreen C.C. , Sancak Y. , Kang S.A. , Kuehl W.M. , Gray N.S. , Sabatini D.M.
Cell137:873-886(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DEPTOR;ENZYME REGULATION
32.

"Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth."
Acosta-Jaquez H.A. , Keller J.A. , Foster K.G. , Ekim B. , Soliman G.A. , Feener E.P. , Ballif B.A. , Fingar D.C.
Mol. Cell. Biol.29:4308-4324(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1261
33.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1218;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
35.

"mTOR phosphorylated at S2448 binds to raptor and rictor."
Rosner M. , Siegel N. , Valli A. , Fuchs C. , Hengstschlager M.
Amino Acids38:223-228(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-2448
36.

"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids."
Sancak Y. , Bar-Peled L. , Zoncu R. , Markhard A.L. , Nada S. , Sabatini D.M.
Cell141:290-303(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
37.

"DAP1, a novel substrate of mTOR, negatively regulates autophagy."
Koren I. , Reem E. , Kimchi A.
Curr. Biol.20:1093-1098(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF DAP;FUNCTION IN AUTOPHAGY
38.

"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability."
Hurov K.E. , Cotta-Ramusino C. , Elledge S.J.
Genes Dev.24:1939-1950(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TTI1
39.

"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes."
Takai H. , Xie Y. , de Lange T. , Pavletich N.P.
Genes Dev.24:2019-2030(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TELO2
40.

"Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly."
Kaizuka T. , Hara T. , Oshiro N. , Kikkawa U. , Yonezawa K. , Takehana K. , Iemura S. , Natsume T. , Mizushima N.
J. Biol. Chem.285:20109-20116(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TELO2 AND TTI1
41.

"mTORC1 directly phosphorylates and regulates human MAF1."
Michels A.A. , Robitaille A.M. , Buczynski-Ruchonnet D. , Hodroj W. , Reina J.H. , Hall M.N. , Hernandez N.
Mol. Cell. Biol.30:3749-3757(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF RNA POLYMERASE III TRANSCRIPTION;FUNCTION IN PHOSPHORYLATION OF MAF1
42.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-567 AND THR-1162;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
43.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
44.

"mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression."
Ekim B. , Magnuson B. , Acosta-Jaquez H.A. , Keller J.A. , Feener E.P. , Fingar D.C.
Mol. Cell. Biol.31:2787-2801(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-2159; THR-2164 AND SER-2481;MUTAGENESIS OF SER-2159 AND THR-2164
45.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
46.

"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling."
Hsu P.P. , Kang S.A. , Rameseder J. , Zhang Y. , Ottina K.A. , Lim D. , Peterson T.R. , Choi Y. , Gray N.S. , Yaffe M.B. , Marto J.A. , Sabatini D.M.
Science332:1317-1322(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF GRB10;FUNCTION IN INSR-DEPENDENT SIGNALING
47.

"5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia."
Meffre J. , Chaumont-Dubel S. , Mannoury la Cour C. , Loiseau F. , Watson D.J. , Dekeyne A. , Seveno M. , Rivet J.M. , Gaven F. , Deleris P. , Herve D. , Fone K.C. , Bockaert J. , Millan M.J. , Marin P.
EMBO Mol. Med.4:1043-1056(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HTR6
48.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
49.

"Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition."
Halova L. , Du W. , Kirkham S. , Smith D.L. , Petersen J.
J. Cell Biol.203:595-604(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-2173;MUTAGENESIS OF THR-2173
50.

"Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains."
Wang J.Q. , Chen J.H. , Chen Y.C. , Chen M.Y. , Hsieh C.Y. , Teng S.C. , Wu K.J.
PLoS ONE8:E65586-E65586(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NBN
51.

"Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis."
Robitaille A.M. , Christen S. , Shimobayashi M. , Cornu M. , Fava L.L. , Moes S. , Prescianotto-Baschong C. , Sauer U. , Jenoe P. , Hall M.N.
Science339:1320-1323(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION OF RPS6KB1;REGULATION OF PYRIMIDINE SYNTHESIS
52.

"Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1."
Ben-Sahra I. , Howell J.J. , Asara J.M. , Manning B.D.
Science339:1323-1328(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION OF RPS6KB1;REGULATION OF PYRIMIDINE SYNTHESIS
53.

"Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP."
Choi J. , Chen J. , Schreiber S.L. , Clardy J.
Science273:239-242(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 2018-2112 IN COMPLEX WITH FKBP1A AND INHIBITOR RAPAMYCIN
54.

"Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution."
Liang J. , Choi J. , Clardy J.
Acta Crystallogr. D55:736-744(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2018-2112 IN COMPLEX WITH FKBP1A AND INHIBITOR RAPAMYCIN
55.

"Insights into the domain and repeat architecture of target of rapamycin."
Knutson B.A.
J. Struct. Biol.170:354-363(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING;HEAT-REPEATS;TPR-REPEATS
56.

"Structure of the human mTOR complex I and its implications for rapamycin inhibition."
Yip C.K. , Murata K. , Walz T. , Sabatini D.M. , Kang S.A.
Mol. Cell38:768-774(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CRYO-ELECTRON MICROSCOPY (26 ANGSTROMS) OF MTORC1 COMPLEX;SUBUNIT
57.

"mTOR kinase structure, mechanism and regulation."
Yang H. , Rudge D.G. , Koos J.D. , Vaidialingam B. , Yang H.J. , Pavletich N.P.
Nature497:217-223(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 1376-2549 IN COMPLEX WITH MLST8;SUBUNIT;TPR-REPEATS;DOMAINS;MUTAGENESIS OF HIS-2340
58.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] SER-8; THR-135; VAL-1083; VAL-1134; PHE-1178; VAL-2011; TYR-2215 AND LEU-2476
59.

"Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma."
Varela I. , Tarpey P. , Raine K. , Huang D. , Ong C.K. , Stephens P. , Davies H. , Jones D. , Lin M.L. , Teague J. , Bignell G. , Butler A. , Cho J. , Dalgliesh G.L. , Galappaththige D. , Greenman C. , Hardy C. , Jia M. , more...
Nature469:539-542(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PHE-2220 AND ALA-2406

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