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Index > Protein center > NLRP3(Gene name) > Human
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  • NLRP3 (Gene name),
  • NACHT, LRR and PYD domains-containing protein 3 (Protein name ),  NALP3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NLRP3(C1orf7;CIAS1;NALP3;PYPAF1);
    Protein name:
    NACHT, LRR and PYD domains-containing protein 3;
    Alternative:
    PYRIN-containing APAF1-like protein 1;Cryopyrin;Cold autoinflammatory syndrome 1 protein;Angiotensin/vasopressin receptor AII/AVP-like;Caterpiller protein 1.1(CLR1.1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18.
    Function:
    May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1036
    Sequence:
    50:
    MKMASTRCKL | ARYLEDLEDV | DLKKFKMHLE | DYPPQKGCIP | LPRGQTEKAD | 
    100:
    HVDLATLMID | FNGEEKAWAM | AVWIFAAINR | RDLYEKAKRD | EPKWGSDNAR | 
    150:
    VSNPTVICQE | DSIEEEWMGL | LEYLSRISIC | KMKKDYRKKY | RKYVRSRFQC | 
    200:
    IEDRNARLGE | SVSLNKRYTR | LRLIKEHRSQ | QEREQELLAI | GKTKTCESPV | 
    250:
    SPIKMELLFD | PDDEHSEPVH | TVVFQGAAGI | GKTILARKMM | LDWASGTLYQ | 
    300:
    DRFDYLFYIH | CREVSLVTQR | SLGDLIMSCC | PDPNPPIHKI | VRKPSRILFL | 
    350:
    MDGFDELQGA | FDEHIGPLCT | DWQKAERGDI | LLSSLIRKKL | LPEASLLITT | 
    400:
    RPVALEKLQH | LLDHPRHVEI | LGFSEAKRKE | YFFKYFSDEA | QARAAFSLIQ | 
    450:
    ENEVLFTMCF | IPLVCWIVCT | GLKQQMESGK | SLAQTSKTTT | AVYVFFLSSL | 
    500:
    LQPRGGSQEH | GLCAHLWGLC | SLAADGIWNQ | KILFEESDLR | NHGLQKADVS | 
    550:
    AFLRMNLFQK | EVDCEKFYSF | IHMTFQEFFA | AMYYLLEEEK | EGRTNVPGSR | 
    600:
    LKLPSRDVTV | LLENYGKFEK | GYLIFVVRFL | FGLVNQERTS | YLEKKLSCKI | 
    650:
    SQQIRLELLK | WIEVKAKAKK | LQIQPSQLEL | FYCLYEMQEE | DFVQRAMDYF | 
    700:
    PKIEINLSTR | MDHMVSSFCI | ENCHRVESLS | LGFLHNMPKE | EEEEEKEGRH | 
    750:
    LDMVQCVLPS | SSHAACSHGL | VNSHLTSSFC | RGLFSVLSTS | QSLTELDLSD | 
    800:
    NSLGDPGMRV | LCETLQHPGC | NIRRLWLGRC | GLSHECCFDI | SLVLSSNQKL | 
    850:
    VELDLSDNAL | GDFGIRLLCV | GLKHLLCNLK | KLWLVSCCLT | SACCQDLASV | 
    900:
    LSTSHSLTRL | YVGENALGDS | GVAILCEKAK | NPQCNLQKLG | LVNSGLTSVC | 
    950:
    CSALSSVLST | NQNLTHLYLR | GNTLGDKGIK | LLCEGLLHPD | CKLQVLELDN | 
    1000:
    CNLTSHCCWD | LSTLLTSSQS | LRKLSLGNND | LGDLGVMMFC | EVLKQQSCLL | 
    1036:
    QNLGLSEMYF | NYETKSALET | LQEEKPELTV | VFEPSW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    E14531m
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    ELISA Kit for Human NACHT, LRR and PYD domains-containing protein 3
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    E14531h
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    ELISA Kit for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    E14531b
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    Packing:
    96T
    CLIA Kit for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    U14531m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    U14531h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    U14531b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    P14531Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Polyclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Cat.:
    P14531Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Monoclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Monoclonal Antibody for Human NACHT, LRR and PYD domains-containing protein 3
    Protein for Human NACHT, LRR and PYD domains-containing protein 3
    Protein for Human NACHT, LRR and PYD domains-containing protein 3
    Protein for Human NACHT, LRR and PYD domains-containing protein 3

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    Precision
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    Linearity
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    References
    1. 1.
      "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome."
      Hoffman H.M. , Mueller J.L. , Broide D.H. , Wanderer A.A. , Kolodner R.D.
      Nat. Genet.29:301-305(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2);VARIANTS FCAS1 MET-200; VAL-441 AND GLY-629;VARIANT MWS VAL-354
    2. 2.
      "Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis."
      Aganna E. , Martinon F. , Hawkins P.N. , Ross J.B. , Swan D.C. , Booth D.R. , Lachmann H.J. , Gaudet R. , Woo P. , Feighery C. , Cotter F.E. , Thome M. , Hitman G.A. , Tschopp J. , McDermott M.F.
      Arthritis Rheum.46:2445-2452(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);VARIANT MWS MET-200;VARIANTS FCAS1/MWS TRP-262 AND PRO-307
    3. 3.
      "PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB."
      Manji G.A. , Wang L. , Geddes B.J. , Brown M. , Merriam S. , Al-Garawi A. , Mak S. , Lora J.M. , Briskin M. , Jurman M. , Cao J. , DiStefano P.S. , Bertin J.
      J. Biol. Chem.277:11570-11575(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH PYCARD/ASC;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    4. 4.
      "CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties."
      O'Connor W. Jr. , Harton J.A. , Zhu X. , Linhoff M.W. , Ting J.-P.
      J. Immunol.171:6329-6333(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 4);FUNCTION;SUBCELLULAR LOCATION;INDUCTION BY TNF
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Brain.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 4 AND 6)
      tissue: Colon.
    10. 10.
      "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H. , Ye M. , Wu X.-Y. , Ren S.-X. , Zhao M. , Zhao C.-J. , Fu G. , Shen Y. , Fan H.-Y. , Lu G. , Zhong M. , Xu X.-R. , Han Z.-G. , Zhang J.-W. , Tao J. , Huang Q.-H. , Zhou J. , Hu G.-X. , more...
      Genome Res.10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 393-1036 (ISOFORM 1)
      tissue: Umbilical cord blood.
    11. 11.
      "NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
      Agostini L. , Martinon F. , Burns K. , McDermott M.F. , Hawkins P.N. , Tschopp J.
      Immunity20:319-325(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN NALP3 INFLAMMASOME COMPLEX
    12. 12.
      "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
      Papin S. , Cuenin S. , Agostini L. , Martinon F. , Werner S. , Beer H.D. , Grutter C. , Grutter M. , Tschopp J.
      Cell Death Differ.14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEFV
    13. 13.
      "Inflammasome components NALP 1 and 3 Show distinct but separate Expression profiles in human tissues suggesting a site-specific role in the inflammatory response."
      Kummer J.A. , Broekhuizen R. , Everett H. , Agostini L. , Kuijk L. , Martinon F. , van Bruggen R. , Tschopp J.
      J. Histochem. Cytochem.55:443-452(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    14. 14.
      "Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death."
      McCall S.H. , Sahraei M. , Young A.B. , Worley C.S. , Duncan J.A. , Ting J.P. , Marriott I.
      J. Bone Miner. Res.23:30-40(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EIF2AK2
    16. 16.
      "Selective inhibition of the NLRP3 inflammasome by targeting to promyelocytic leukemia protein in mouse and human."
      Lo Y.H. , Huang Y.W. , Wu Y.H. , Tsai C.S. , Lin Y.C. , Mo S.T. , Kuo W.C. , Chuang Y.T. , Jiang S.T. , Shih H.M. , Lai M.Z.
      Blood121:3185-3194(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PML
    17. 17.
      "Crystal structure of NALP3 protein pyrin domain (PYD) and its implications in inflammasome assembly."
      Bae J.Y. , Park H.H.
      J. Biol. Chem.286:39528-39536(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 3-112;SUBUNIT;DISULFIDE BOND
    18. 18.
      "New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes."
      Dode C. , Le Du N. , Cuisset L. , Letourneur F. , Berthelot J.-M. , Vaudour G. , Meyrier A. , Watts R.A. , Scott D.G.I. , Nicholls A. , Granel B. , Frances C. , Garcier F. , Edery P. , Boulinguez S. , Domergues J.-P. , Delpech M. , Grateau G.
      Am. J. Hum. Genet.70:1498-1506(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCAS1 MET-200;VARIANTS MWS ASN-305; MET-350; THR-441 AND ARG-571;VARIANT FCAS/MWS TRP-262
    19. 19.
      "Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes."
      Feldmann J. , Prieur A.-M. , Quartier P. , Berquin P. , Certain S. , Cortis E. , Teillac-Hamel D. , Fischer A. , de Saint Basile G.
      Am. J. Hum. Genet.71:198-203(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CINCA ASN-305; LEU-308; SER-311; ARG-360; ASN-438; SER-575 AND THR-664;TISSUE SPECIFICITY
    20. 20.
      "De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases."
      Aksentijevich I. , Nowak M. , Mallah M. , Chae J.J. , Watford W.T. , Hofmann S.R. , Stein L. , Russo R. , Goldsmith D. , Dent P. , Rosenberg H.F. , Austin F. , Remmers E.F. , Balow J.E. Jr. , Rosenzweig S. , Komarow H. , Shoham N.G. , Wood G. , more...
      Arthritis Rheum.46:3340-3348(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CINCA HIS-266; ASN-305; LEU-525 AND CYS-572
    21. 21.
      "Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P."
      Hoffman H.M. , Gregory S.G. , Mueller J.L. , Tresierras M. , Broide D.H. , Wanderer A.A. , Kolodner R.D.
      Hum. Genet.112:209-216(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCAS1 PRO-355;VARIANT LYS-705
    22. 22.
      "Variant chronic infantile neurologic, cutaneous, articular syndrome due to a mutation within the leucine-rich repeat domain of CIAS1."
      Frenkel J. , van Kempen M.J. , Kuis W. , van Amstel H.K.
      Arthritis Rheum.50:2719-2720(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CINCA CYS-861
    23. 23.
      "Clinical and genetic heterogeneity among Spanish patients with recurrent autoinflammatory syndromes associated with the CIAS1/PYPAF1/NALP3 gene."
      Arostegui J.I. , Aldea A. , Modesto C. , Rua M.J. , Argueelles F. , Gonzalez-Ensenat M.A. , Ramos E. , Rius J. , Plaza S. , Vives J. , Yaguee J.
      Arthritis Rheum.50:4045-4050(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FCAS1 MET-200; PRO-307 AND LYS-490;VARIANT CINCA ASN-305;VARIANT MWS MET-350
    24. 24.
      "Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU."
      Neven B. , Callebaut I. , Prieur A.-M. , Feldmann J. , Bodemer C. , Lepore L. , Derfalvi B. , Benjaponpitak S. , Vesely R. , Sauvain M.J. , Oertle S. , Allen R. , Morgan G. , Borkhardt A. , Hill C. , Gardner-Medwin J. , Fischer A. , de Saint Basile G.
      Blood103:2809-2815(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CINCA LEU-262; PRO-262; ASN-305; GLY-305; SER-311; MET-350; ASP-356; PRO-407; ILE-438; CYS-572 AND PHE-634
    25. 25.
      "A novel CIAS1 mutation and plasma/cerebrospinal fluid cytokine profile in a German patient with neonatal-onset multisystem inflammatory disease responsive to methotrexate therapy."
      Stojanov S. , Weiss M. , Lohse P. , Belohradsky B.H.
      Pediatrics114:E124-E127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CINCA THR-174
    26. 26.
      "A novel missense mutation in CIAS1 encoding the pyrin-like protein, cryopyrin, causes familial cold autoinflammatory syndrome in a family of Ethiopian origin."
      Shalev S.A. , Sprecher E. , Indelman M. , Hujirat Y. , Bergman R. , Rottem M.
      Int. Arch. Allergy Immunol.143:190-193(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FCAS1 CYS-525
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