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Index > Protein center > NCOA3(Gene name) > Human
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  • NCOA3 (Gene name),
  • Nuclear receptor coactivator 3 (Protein name ),  NCOA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NCOA3(AIB1;BHLHE42;RAC3;TRAM1);
    Protein name:
    Nuclear receptor coactivator 3(NCoA-3);
    Alternative:
    Steroid receptor coactivator protein 3(SRC-3);Receptor-associated coactivator 3(RAC-3);Class E basic helix-loop-helix protein 42(bHLHe42);CBP-interacting protein(pCIP);Thyroid hormone receptor activator molecule 1(TRAM-1);ACTR;Amplified in breast cancer 1 protein(AIB-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CARM1 (By similarity). Present in a complex containing NCOA2, IKKA, IKKB, IKBKG and the histone acetyltransferase protein CREBBP. Interacts with CASP8AP2, NR3C1 and PCAF. Interacts with ATAD2 and this interaction is enhanced by estradiol.
    Function:
    Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. Interacts with PSMB9.
    Subcellular Location:
    Cytoplasm Nucleus Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
    Protein Attributes:
    Sequence length:
    1424
    Sequence:
    50:
    MSGLGENLDP | LASDSRKRKL | PCDTPGQGLT | CSGEKRRREQ | ESKYIEELAE | 
    100:
    LISANLSDID | NFNVKPDKCA | ILKETVRQIR | QIKEQGKTIS | NDDDVQKADV | 
    150:
    SSTGQGVIDK | DSLGPLLLQA | LDGFLFVVNR | DGNIVFVSEN | VTQYLQYKQE | 
    200:
    DLVNTSVYNI | LHEEDRKDFL | KNLPKSTVNG | VSWTNETQRQ | KSHTFNCRML | 
    250:
    MKTPHDILED | INASPEMRQR | YETMQCFALS | QPRAMMEEGE | DLQSCMICVA | 
    300:
    RRITTGERTF | PSNPESFITR | HDLSGKVVNI | DTNSLRSSMR | PGFEDIIRRC | 
    350:
    IQRFFSLNDG | QSWSQKRHYQ | EAYLNGHAET | PVYRFSLADG | TIVTAQTKSK | 
    400:
    LFRNPVTNDR | HGFVSTHFLQ | REQNGYRPNP | NPVGQGIRPP | MAGCNSSVGG | 
    450:
    MSMSPNQGLQ | MPSSRAYGLA | DPSTTGQMSG | ARYGGSSNIA | SLTPGPGMQS | 
    500:
    PSSYQNNNYG | LNMSSPPHGS | PGLAPNQQNI | MISPRNRGSP | KIASHQFSPV | 
    550:
    AGVHSPMASS | GNTGNHSFSS | SSLSALQAIS | EGVGTSLLST | LSSPGPKLDN | 
    600:
    SPNMNITQPS | KVSNQDSKSP | LGFYCDQNPV | ESSMCQSNSR | DHLSDKESKE | 
    650:
    SSVEGAENQR | GPLESKGHKK | LLQLLTCSSD | DRGHSSLTNS | PLDSSCKESS | 
    700:
    VSVTSPSGVS | SSTSGGVSST | SNMHGSLLQE | KHRILHKLLQ | NGNSPAEVAK | 
    750:
    ITAEATGKDT | SSITSCGDGN | VVKQEQLSPK | KKENNALLRY | LLDRDDPSDA | 
    800:
    LSKELQPQVE | GVDNKMSQCT | SSTIPSSSQE | KDPKIKTETS | EEGSGDLDNL | 
    850:
    DAILGDLTSS | DFYNNSISSN | GSHLGTKQQV | FQGTNSLGLK | SSQSVQSIRP | 
    900:
    PYNRAVSLDS | PVSVGSSPPV | KNISAFPMLP | KQPMLGGNPR | MMDSQENYGS | 
    950:
    SMGGPNRNVT | VTQTPSSGDW | GLPNSKAGRM | EPMNSNSMGR | PGGDYNTSLP | 
    1000:
    RPALGGSIPT | LPLRSNSIPG | ARPVLQQQQQ | MLQMRPGEIP | MGMGANPYGQ | 
    1050:
    AAASNQLGSW | PDGMLSMEQV | SHGTQNRPLL | RNSLDDLVGP | PSNLEGQSDE | 
    1100:
    RALLDQLHTL | LSNTDATGLE | EIDRALGIPE | LVNQGQALEP | KQDAFQGQEA | 
    1150:
    AVMMDQKAGL | YGQTYPAQGP | PMQGGFHLQG | QSPSFNSMMN | QMNQQGNFPL | 
    1200:
    QGMHPRANIM | RPRTNTPKQL | RMQLQQRLQG | QQFLNQSRQA | LELKMENPTA | 
    1250:
    GGAAVMRPMM | QPQVSSQQGF | LNAQMVAQRS | RELLSHHFRQ | QRVAMMMQQQ | 
    1300:
    QQQQQQQQQQ | QQQQQQQQQQ | QQQQQQTQAF | SPPPNVTASP | SMDGLLAGPT | 
    1350:
    MPQAPPQQFP | YQPNYGMGQQ | PDPAFGRVSS | PPNAMMSSRM | GPSQNPMMQH | 
    1400:
    PQAASIYQSS | EMKGWPSGNL | ARNSSFSQQQ | FAHQGNPAVY | SMVHMNGSSG | 
    1424:
    HMGQMNMNPM | PMSGMPMGPD | QKYC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human NCoA-3
    Cat.:
    E11290m
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    Packing:
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    ELISA Kit for Human NCoA-3
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    E11290r
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    MSDS:
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    ELISA Kit for Human NCoA-3
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    E11290h
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    MSDS:
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    CLIA Kit for Human NCoA-3
    Cat.:
    U11290m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NCoA-3
    Cat.:
    U11290r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NCoA-3
    Cat.:
    U11290h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NCoA-3
    Cat.:
    P11290Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NCoA-3
    Cat.:
    P11290Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NCoA-3
    Cat.:
    P11290Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NCoA-3
    Monoclonal Antibody for Human NCoA-3
    Monoclonal Antibody for Human NCoA-3
    Protein for Human NCoA-3
    Protein for Human NCoA-3
    Protein for Human NCoA-3

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    Recovery
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    Linearity
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    References
    1. 1.
      "TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1."
      Takeshita A. , Cardona G.R. , Koibuchi N. , Suen C.-S. , Chin W.W.
      J. Biol. Chem.272:27629-27634(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);INTERACTION WITH CREBBP; PCAF; RARA; RXRA; THRA AND ESR
      tissue: Pituitary.
    2. 2.
      "Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300."
      Chen H. , Lin R.J. , Schiltz R.L. , Chakravarti D. , Nash A. , Nagy L. , Privalsky M.L. , Nakatani Y. , Evans R.M.
      Cell90:569-580(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);ENZYME ACTIVITY;VARIANT 1248-GLN--GLN-1250 DEL
      tissue: Leukemia.
    3. 3.
      "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer."
      Anzick S.L. , Kononen J. , Walker R.L. , Azorsa D.O. , Tanner M.M. , Guan X.-Y. , Sauter G. , Kallioniemi O.-P. , Trent J.M. , Meltzer P.S.
      Science277:965-968(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);INTERACTION WITH ESR
      tissue: Lung.
    4. 4.
      "RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2."
      Li H. , Gomes P.J. , Chen J.D.
      Proc. Natl. Acad. Sci. U.S.A.94:8479-8484(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);INTERACTION WITH VDR; RARA; PPARA; RXRA; THRA AND ESR;VARIANT 1248-GLN--GLN-1250 DEL
      tissue: Brain.
    5. 5.
      NIEHS SNPs program
      Submitted (2007-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-218; ILE-220; VAL-556; SER-559; HIS-586; ALA-777; LEU-1247 AND LYS-1247
    6. 6.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
    9. 9.
      "Polymorphic exonic CAG microsatellites in the gene amplified in breast cancer (AIB1 gene)."
      Shirazi S.K. , Bober M.A. , Coetzee G.A.
      Clin. Genet.54:102-103(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF POLY-GLN REGION
    10. 10.
      "Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase."
      Chen H. , Lin R.J. , Xie W. , Wilpitz D. , Evans R.M.
      Cell98:675-686(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-616; LYS-619 AND LYS-620 BY CREBBP;MUTAGENESIS OF LYS-616; 619-LYS-LYS-620; LYS-647; LYS-681; LYS-687; LYS-700 AND LYS-708
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NFKB1
    12. 12.
      "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA."
      Watanabe M. , Yanagisawa J. , Kitagawa H. , Takeyama K. , Ogawa S. , Arao Y. , Suzawa M. , Kobayashi Y. , Yano T. , Yoshikawa H. , Masuhiro Y. , Kato S.
      EMBO J.20:1341-1352(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDX5
    13. 13.
      "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) coactivator activity by I kappa B kinase."
      Wu R.-C. , Qin J. , Hashimoto Y. , Wong J. , Xu J. , Tsai S.Y. , Tsai M.-J. , O'Malley B.W.
      Mol. Cell. Biol.22:3549-3561(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT OF A COMPLEX CONTAINING CREBBP; NCOA2; IKKA; IKKB AND IKBKG;PHOSPHORYLATION
    14. 14.
      "BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation."
      Hsiao P.W. , Fryer C.J. , Trotter K.W. , Wang W. , Archer T.K.
      Mol. Cell. Biol.23:6210-6220(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR3C1
    15. 15.
      "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock."
      Curtis A.M. , Seo S.B. , Westgate E.J. , Rudic R.D. , Smyth E.M. , Chakravarti D. , FitzGerald G.A. , McNamara P.
      J. Biol. Chem.279:7091-7097(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NPAS2
    16. 16.
      "FLASH interacts with p160 coactivator subtypes and differentially suppresses transcriptional activity of steroid hormone receptors."
      Kino T. , Ichijo T. , Chrousos G.P.
      J. Steroid Biochem. Mol. Biol.92:357-363(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP8AP2
    17. 17.
      "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells."
      Ma A.H. , Xia L. , Desai S.J. , Boucher D.L. , Guan Y. , Shih H.M. , Shi X.B. , deVere White R.W. , Chen H.W. , Tepper C.G. , Kung H.J.
      Cancer Res.66:8439-8447(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    18. 18.
      "The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription."
      Zhang H. , Sun L. , Liang J. , Yu W. , Zhang Y. , Wang Y. , Chen Y. , Li R. , Sun X. , Shang Y.
      EMBO J.25:4223-4233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSMB9
    19. 19.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-867;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification."
      Zou J.X. , Revenko A.S. , Li L.B. , Gemo A.T. , Chen H.-W.
      Proc. Natl. Acad. Sci. U.S.A.104:18067-18072(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATAD2
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; SER-551; SER-728 AND SER-857;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "CK1delta modulates the transcriptional activity of ERalpha via AIB1 in an estrogen-dependent manner and regulates ERalpha-AIB1 interactions."
      Giamas G. , Castellano L. , Feng Q. , Knippschild U. , Jacob J. , Thomas R.S. , Coombes R.C. , Smith C.L. , Jiao L.R. , Stebbing J.
      Nucleic Acids Res.37:3110-3123(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-601 BY CSNK1D/CK1;INTERACTION WITH CSNK1D
    24. 24.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    25. 25.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-687;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    26. 26.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; SER-857 AND SER-867;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    27. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    28. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
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