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Index > Protein center > NTN1(Gene name) > Human
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  • NTN1 (Gene name),
  • Netrin-1 (Protein name ),  NET1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (4)
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  • Gene name:
    NTN1(NTN1L);
    Protein name:
    Netrin-1;
    Alternative:
    Epididymis tissue protein Li 131P;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D.
    Function:
    Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    604
    Sequence:
    50:
    MMRAVWEALA | ALAAVACLVG | AVRGGPGLSM | FAGQAAQPDP | CSDENGHPRR | 
    100:
    CIPDFVNAAF | GKDVRVSSTC | GRPPARYCVV | SERGEERLRS | CHLCNASDPK | 
    150:
    KAHPPAFLTD | LNNPHNLTCW | QSENYLQFPH | NVTLTLSLGK | KFEVTYVSLQ | 
    200:
    FCSPRPESMA | IYKSMDYGRT | WVPFQFYSTQ | CRKMYNRPHR | APITKQNEQE | 
    250:
    AVCTDSHTDM | RPLSGGLIAF | STLDGRPSAH | DFDNSPVLQD | WVTATDIRVA | 
    300:
    FSRLHTFGDE | NEDDSELARD | SYFYAVSDLQ | VGGRCKCNGH | AARCVRDRDD | 
    350:
    SLVCDCRHNT | AGPECDRCKP | FHYDRPWQRA | TAREANECVA | CNCNLHARRC | 
    400:
    RFNMELYKLS | GRKSGGVCLN | CRHNTAGRHC | HYCKEGYYRD | MGKPITHRKA | 
    450:
    CKACDCHPVG | AAGKTCNQTT | GQCPCKDGVT | GITCNRCAKG | YQQSRSPIAP | 
    500:
    CIKIPVAPPT | TAASSVEEPE | DCDSYCKASK | GKLKINMKKY | CKKDYAVQIH | 
    550:
    ILKADKAGDW | WKFTVNIISV | YKQGTSRIRR | GDQSLWIRSR | DIACKCPKIK | 
    600:
    PLKKYLLLGN | AEDSPDQSGI | VADKSSLVIQ | WRDTWARRLR | KFQQREKKGK | 
    604:
    CKKA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Netrin-1
    Cat.:
    E1827h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Netrin-1
    Cat.:
    E1827m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human Netrin-1
    Cat.:
    E1827r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Netrin-1
    Cat.:
    E1827c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Netrin-1
    Cat.:
    E1827p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin-1
    Cat.:
    U1827c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin-1
    Cat.:
    U1827r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin-1
    Cat.:
    U1827p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Netrin-1
    Cat.:
    U1827m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Netrin-1
    Cat.:
    U1827h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Netrin-1
    Cat.:
    P1827Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Netrin-1
    Polyclonal Antibody for Human Netrin-1
    Polyclonal Antibody for Human Netrin-1
    Cat.:
    P1827Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Netrin-1
    Cat.:
    P1827Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Netrin-1
    Monoclonal Antibody for Human Netrin-1
    Monoclonal Antibody for Human Netrin-1
    Monoclonal Antibody for Human Netrin-1
    Monoclonal Antibody for Human Netrin-1
    Protein for Human Netrin-1
    Protein for Human Netrin-1
    Protein for Human Netrin-1
    Protein for Human Netrin-1
    Protein for Human Netrin-1

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas."
      Meyerhardt J.A. , Caca K. , Eckstrand B.C. , Hu G. , Lengauer C. , Banavali S. , Look A.T. , Fearon E.R.
      Cell Growth Differ.10:35-42(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH DCC;TISSUE SPECIFICITY;VARIANTS HIS-351 AND GLU-489
      tissue: Brain stem.
      tissue: Liver.
    2. 3.
      "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
      Li J. , Liu F. , Wang H. , Liu X. , Liu J. , Li N. , Wan F. , Wang W. , Zhang C. , Jin S. , Liu J. , Zhu P. , Liu Y.
      Mol. Cell. Proteomics9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Epididymis.
    3. 4.
      "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis."
      Mazelin L. , Bernet A. , Bonod-Bidaud C. , Pays L. , Arnaud S. , Gespach C. , Bredesen D.E. , Scoazec J.-Y. , Mehlen P.
      Nature431:80-84(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    4. 5.
      "DSCAM functions as a netrin receptor in commissural axon pathfinding."
      Liu G. , Li W. , Wang L. , Kar A. , Guan K.L. , Rao Y. , Wu J.Y.
      Proc. Natl. Acad. Sci. U.S.A.106:2951-2956(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DSCAM
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