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Index > Protein center > Nfkb1(Gene name) > Rat
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  • Nfkb1 (Gene name),
  • Nuclear factor NF-kappa-B p105 subunit (Protein name ),  NFKB1_RAT from NCBI database.
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  • Gene name:
    Nfkb1;
    Protein name:
    Nuclear factor NF-kappa-B p105 subunit;
    Alternative:
    EBP-1;DNA-binding factor KBF1;Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1.
    Function:
    NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. Plays a role in the regulation of apoptosis. Isoform 5, isoform 6 and isoform 7 act as inhibitors of transactivation of p50 NF-kappa-B subunit, probably by sequestering it in the cytoplasm. Isoform 3 (p98) (but not p84 or p105) acts as a transactivator of NF-kappa-B-regulated gene expression. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
    Subcellular Location:
    Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B).
    Protein Attributes:
    Sequence length:
    522
    Sequence:
    50:
    REILNPPEKE | TQGEGPSLFM | ASTKTEAIAP | ASTMEDKEED | VGFQDNLFLE | 
    100:
    KALQLAKRHA | NALFDYAVTG | DVKMLLAVQR | HLTAVQDENG | DSVLHLAIIH | 
    150:
    LHAQLVRDLL | EVTSGSISDD | IINMRNDLYQ | TPLHLAVITK | QEDVVEDLLR | 
    200:
    VGADLSLLDR | WGNSVLHLAA | KEGHDKILGV | LLKNSKAALL | INHPNGEGLN | 
    250:
    AIHIAVMSNS | LSCLQLLVAA | GAEVNAQEQK | SGRTALHLAV | EYDNISLAGC | 
    300:
    LLLEGDALVD | STTYDGTTPL | HIAAGRGSTR | LAALLKAAGA | DPLVENFEPL | 
    350:
    YDLDDSWEKA | GEDEGVVPGT | TPLDMAANWQ | VFDILNGKPY | EPVFTSDDIL | 
    400:
    PQGDIKQLTE | DTRLQLCKLL | EIPDPDKNWA | TLAQKLGLGI | LNNAFRLSPA | 
    450:
    PSKTLMDNYE | VSGGTIKELV | EALRQMGYTE | AIEVIQAAFR | TPETTASSPV | 
    500:
    TTAQAHLLPL | SSSSTRQHID | ELRDNDSVCD | SGVETSFRKL | SFSESLTGDG | 
    522:
    PLLSLNKMPH | NYGQDGPIEG | KI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824r
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824d
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    E1824m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    U1824h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Cat.:
    P1824Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Monoclonal Antibody for Rat Nuclear factor NF-kappa-B p105 subunit
    Protein for Rat Nuclear factor NF-kappa-B p105 subunit
    Protein for Rat Nuclear factor NF-kappa-B p105 subunit
    Protein for Rat Nuclear factor NF-kappa-B p105 subunit
    Protein for Rat Nuclear factor NF-kappa-B p105 subunit
    Protein for Rat Nuclear factor NF-kappa-B p105 subunit

    R&D Technical Data
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    Precision
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    Linearity
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    Citations
    References
    1. 1.
      "Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression."
      Hamil K.G. , Hall S.H.
      Endocrinology134:1205-1212(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Testis.
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