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Index > Protein center > NLRC5(Gene name) > Human
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  • NLRC5 (Gene name),
  • Protein NLRC5 (Protein name ),  NLRC5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    NLRC5(NOD27;NOD4);
    Protein name:
    Protein NLRC5;
    Alternative:
    Nucleotide-binding oligomerization domain protein 27;Caterpiller protein 16.1(CLR16.1);Nucleotide-binding oligomerization domain protein 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with CHUK and IKBKB; prevents CHUK and IKBKB phosphorylation and inhibits their kinase activity. Interacts with DDX58 and IFIH1; blocks the interaction of MAVS to DDX58.
    Function:
    Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1866
    Sequence:
    50:
    MDPVGLQLGN | KNLWSCLVRL | LTKDPEWLNA | KMKFFLPNTD | LDSRNETLDP | 
    100:
    EQRVILQLNK | LHVQGSDTWQ | SFIHCVCMQL | EVPLDLEVLL | LSTFGYDDGF | 
    150:
    TSQLGAEGKS | QPESQLHHGL | KRPHQSCGSS | PRRKQCKKQQ | LELAKKYLQL | 
    200:
    LRTSAQQRYR | SQIPGSGQPH | AFHQVYVPPI | LRRATASLDT | PEGAIMGDVK | 
    250:
    VEDGADVSIS | DLFNTRVNKG | PRVTVLLGKA | GMGKTTLAHR | LCQKWAEGHL | 
    300:
    NCFQALFLFE | FRQLNLITRF | LTPSELLFDL | YLSPESDHDT | VFQYLEKNAD | 
    350:
    QVLLIFDGLD | EALQPMGPDG | PGPVLTLFSH | LCNGTLLPGC | RVMATSRPGK | 
    400:
    LPACLPAEAA | MVHMLGFDGP | RVEEYVNHFF | SAQPSREGAL | VELQTNGRLR | 
    450:
    SLCAVPALCQ | VACLCLHHLL | PDHAPGQSVA | LLPNMTQLYM | QMVLALSPPG | 
    500:
    HLPTSSLLDL | GEVALRGLET | GKVIFYAKDI | APPLIAFGAT | HSLLTSFCVC | 
    550:
    TGPGHQQTGY | AFTHLSLQEF | LAALHLMASP | KVNKDTLTQY | VTLHSRWVQR | 
    600:
    TKARLGLSDH | LPTFLAGLAS | CTCRPFLSHL | AQGNEDCVGA | KQAAVVQVLK | 
    650:
    KLATRKLTGP | KVVELCHCVD | ETQEPELASL | TAQSLPYQLP | FHNFPLTCTD | 
    700:
    LATLTNILEH | REAPIHLDFD | GCPLEPHCPE | ALVGCGQIEN | LSFKSRKCGD | 
    750:
    AFAEALSRSL | PTMGRLQMLG | LAGSKITARG | ISHLVKALPL | CPQLKEVSFR | 
    800:
    DNQLSDQVVL | NIVEVLPHLP | RLRKLDLSSN | SICVSTLLCL | ARVAVTCPTV | 
    850:
    RMLQAREADL | IFLLSPPTET | TAELQRAPDL | QESDGQRKGA | QSRSLTLRLQ | 
    900:
    KCQLQVHDAE | ALIALLQEGP | HLEEVDLSGN | QLEDEGCRLM | AEAASQLHIA | 
    950:
    RKLDLSNNGL | SVAGVHCVLR | AVSACWTLAE | LHISLQHKTV | IFMFAQEPEE | 
    1000:
    QKGPQERAAF | LDSLMLQMPS | ELPLSSRRMR | LTHCGLQEKH | LEQLCKALGG | 
    1050:
    SCHLGHLHLD | FSGNALGDEG | AARLAQLLPG | LGALQSLNLS | ENGLSLDAVL | 
    1100:
    GLVRCFSTLQ | WLFRLDISFE | SQHILLRGDK | TSRDMWATGS | LPDFPAAAKF | 
    1150:
    LGFRQRCIPR | SLCLSECPLE | PPSLTRLCAT | LKDCPGPLEL | QLSCEFLSDQ | 
    1200:
    SLETLLDCLP | QLPQLSLLQL | SQTGLSPKSP | FLLANTLSLC | PRVKKVDLRS | 
    1250:
    LHHATLHFRS | NEEEEGVCCG | RFTGCSLSQE | HVESLCWLLS | KCKDLSQVDL | 
    1300:
    SANLLGDSGL | RCLLECLPQV | PISGLLDLSH | NSISQESALY | LLETLPSCPR | 
    1350:
    VREASVNLGS | EQSFRIHFSR | EDQAGKTLRL | SECSFRPEHV | SRLATGLSKS | 
    1400:
    LQLTELTLTQ | CCLGQKQLAI | LLSLVGRPAG | LFSLRVQEPW | ADRARVLSLL | 
    1450:
    EVCAQASGSV | TEISISETQQ | QLCVQLEFPR | QEENPEAVAL | RLAHCDLGAH | 
    1500:
    HSLLVGQLME | TCARLQQLSL | SQVNLCEDDD | ASSLLLQSLL | LSLSELKTFR | 
    1550:
    LTSSCVSTEG | LAHLASGLGH | CHHLEELDLS | NNQFDEEGTK | ALMRALEGKW | 
    1600:
    MLKRLDLSHL | LLNSSTLALL | THRLSQMTCL | QSLRLNRNSI | GDVGCCHLSE | 
    1650:
    ALRAATSLEE | LDLSHNQIGD | AGVQHLATIL | PGLPELRKID | LSGNSISSAG | 
    1700:
    GVQLAESLVL | CRRLEELMLG | CNALGDPTAL | GLAQELPQHL | RVLHLPFSHL | 
    1750:
    GPGGALSLAQ | ALDGSPHLEE | ISLAENNLAG | GVLRFCMELP | LLRQIDLVSC | 
    1800:
    KIDNQTAKLL | TSSFTSCPAL | EVILLSWNLL | GDEAAAELAQ | VLPQMGRLKR | 
    1850:
    VDLEKNQITA | LGAWLLAEGL | AQGSSIQVIR | LWNNPIPCDM | AQHLKSQEPR | 
    1866:
    LDFAFFDNQP | QAPWGT
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    Pfam:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein NLRC5
    ELISA Kit for Human Protein NLRC5
    CLIA Kit for Human Protein NLRC5
    CLIA Kit for Human Protein NLRC5
    Polyclonal Antibody for Human Protein NLRC5
    Polyclonal Antibody for Human Protein NLRC5
    Monoclonal Antibody for Human Protein NLRC5
    Monoclonal Antibody for Human Protein NLRC5
    Protein for Human Protein NLRC5
    Protein for Human Protein NLRC5

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product."
      Dowds T.A. , Masumoto J. , Chen F.F. , Ogura Y. , Inohara N. , Nunez G.
      Biochem. Biophys. Res. Commun.302:575-580(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-907
    2. 2.
      Kronos K.
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASP-907
    3. 3.
      "The nucleotide sequence of a long cDNA clone isolated from human spleen."
      Jikuya H. , Takano J. , Nomura N. , Kikuno R. , Nagase T. , Ohara O.
      Submitted (2002-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 850-1866 (ISOFORM 6);VARIANTS ASP-907 AND LYS-1105
      tissue: Spleen.
    4. 4.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones."
      Jikuya H. , Takano J. , Kikuno R. , Hirosawa M. , Nagase T. , Nomura N. , Ohara O.
      DNA Res.10:49-57(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 274-1866 (ISOFORM 2);VARIANTS LEU-453 AND ARG-500
      tissue: Spleen.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 971-1385 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1030-1866;VARIANT LYS-1105
      tissue: Brain.
      tissue: Ovary.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1067-1866 (ISOFORM 4)
    8. 8.
      "NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways."
      Cui J. , Zhu L. , Xia X. , Wang H.Y. , Legras X. , Hong J. , Ji J. , Shen P. , Zheng S. , Chen Z.J. , Wang R.F.
      Cell141:483-496(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH CHUK; DDX58; IFIH1 AND IKBKB
    9. 9.
      "The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses."
      Kuenzel S. , Till A. , Winkler M. , Hasler R. , Lipinski S. , Jung S. , Grotzinger J. , Fickenscher H. , Schreiber S. , Rosenstiel P.
      J. Immunol.184:1990-2000(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    10. 10.
      "CATERPILLER: a novel gene family important in immunity, cell death, and diseases."
      Ting J.P.-Y. , Davis B.K.
      Annu. Rev. Immunol.23:387-414(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ILE-361
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