Gene name:
GRIN1 (NMDAR1) ;
Protein name:
Glutamate [NMDA] receptor subunit zeta-1 (GluN1) ;
Alternative:
N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). Interacts with GCOM1.
Function:
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
synapse
postsynaptic cell membrane
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Enriched in post-synaptic plasma membrane and post-synaptic densities.
Protein Attributes:
50:
MSTMRLLTLA | LLFSCSVARA | ACDPKIVNIG | AVLSTRKHEQ | MFREAVNQAN |
100:
KRHGSWKIQL | NATSVTHKPN | AIQMALSVCE | DLISSQVYAI | LVSHPPTPND |
150:
HFTPTPVSYT | AGFYRIPVLG | LTTRMSIYSD | KSIHLSFLRT | VPPYSHQSSV |
200:
WFEMMRVYSW | NHIILLVSDD | HEGRAAQKRL | ETLLEERESK | AEKVLQFDPG |
250:
TKNVTALLME | AKELEARVII | LSASEDDAAT | VYRAAAMLNM | TGSGYVWLVG |
300:
EREISGNALR | YAPDGILGLQ | LINGKNESAH | ISDAVGVVAQ | AVHELLEKEN |
350:
ITDPPRGCVG | NTNIWKTGPL | FKRVLMSSKY | ADGVTGRVEF | NEDGDRKFAN |
400:
YSIMNLQNRK | LVQVGIYNGT | HVIPNDRKII | WPGGETEKPR | GYQMSTRLKI |
450:
VTIHQEPFVY | VKPTLSDGTC | KEEFTVNGDP | VKKVICTGPN | DTSPGSPRHT |
500:
VPQCCYGFCI | DLLIKLARTM | NFTYEVHLVA | DGKFGTQERV | NNSNKKEWNG |
550:
MMGELLSGQA | DMIVAPLTIN | NERAQYIEFS | KPFKYQGLTI | LVKKEIPRST |
600:
LDSFMQPFQS | TLWLLVGLSV | HVVAVMLYLL | DRFSPFGRFK | VNSEEEEEDA |
650:
LTLSSAMWFS | WGVLLNSGIG | EGAPRSFSAR | ILGMVWAGFA | MIIVASYTAN |
700:
LAAFLVLDRP | EERITGINDP | RLRNPSDKFI | YATVKQSSVD | IYFRRQVELS |
750:
TMYRHMEKHN | YESAAEAIQA | VRDNKLHAFI | WDSAVLEFEA | SQKCDLVTTG |
800:
ELFFRSGFGI | GMRKDSPWKQ | NVSLSILKSH | ENGFMEDLDK | TWVRYQECDS |
850:
RSNAPATLTF | ENMAGVFMLV | AGGIVAGIFL | IFIEIAYKRH | KDARRKQMQL |
900:
AFAAVNVWRK | NLQDRKSGRA | EPDPKKKATF | RAITSTLASS | FKRRRSSKDT |
938:
STGGGRGALQ | NQKDTVLPRR | AIEREEGQLQ | LCSRHRES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Dog
ELISA Kit for Human GluN1
ELISA Kit for Human GluN1
ELISA Kit for Human GluN1
ELISA Kit for Human GluN1
Polyclonal Antibody for Human GluN1
Polyclonal Antibody for Human GluN1
Polyclonal Antibody for Human GluN1
Polyclonal Antibody for Human GluN1
Monoclonal Antibody for Human GluN1
Monoclonal Antibody for Human GluN1
Monoclonal Antibody for Human GluN1
Monoclonal Antibody for Human GluN1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [MRNA] OF 11-938 (ISOFORM 3);NUCLEOTIDE SEQUENCE [MRNA] OF 300-938 (ISOFORM 2)
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7);VARIANTS MET-540 AND SER-682
6.
"DNA sequence and analysis of human chromosome 9."
Humphray S.J.
,
Oliver K.
,
Hunt A.R.
,
Plumb R.W.
,
Loveland J.E.
,
Howe K.L.
,
Andrews T.D.
,
Searle S.
,
Hunt S.E.
,
Scott C.E.
,
Jones M.C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Babbage S.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Bray-Allen S.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Chen Y.
,
Clarke G.
,
Clark S.Y.
,
Clee C.M.
,
Clegg S.
,
Collier R.E.
,
Corby N.
,
Crosier M.
,
Cummings A.T.
,
Davies J.
,
Dhami P.
,
Dunn M.
,
Dutta I.
,
Dyer L.W.
,
Earthrowl M.E.
,
Faulkner L.
,
Fleming C.J.
,
Frankish A.
,
Frankland J.A.
,
French L.
,
Fricker D.G.
,
Garner P.
,
Garnett J.
,
Ghori J.
,
Gilbert J.G.R.
,
Glison C.
,
Grafham D.V.
,
Gribble S.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Guy J.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Harrison E.S.I.
,
Hart E.A.
,
Heath P.D.
,
Henderson C.D.
,
Hopkins B.L.
,
Howard P.J.
,
Howden P.J.
,
Huckle E.
,
Johnson C.
,
Johnson D.
,
Joy A.A.
,
Kay M.
,
Keenan S.
,
Kershaw J.K.
,
Kimberley A.M.
,
King A.
,
Knights A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.
,
Lloyd D.M.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
McLaren S.
,
McLay K.E.
,
McMurray A.
,
Milne S.
,
Nickerson T.
,
Nisbett J.
,
Nordsiek G.
,
Pearce A.V.
,
Peck A.I.
,
Porter K.M.
,
Pandian R.
,
Pelan S.
,
Phillimore B.
,
Povey S.
,
Ramsey Y.
,
Rand V.
,
Scharfe M.
,
Sehra H.K.
,
Shownkeen R.
,
Sims S.K.
,
Skuce C.D.
,
Smith M.
,
Steward C.A.
,
Swarbreck D.
,
Sycamore N.
,
Tester J.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Thomas D.W.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
Whitehead S.L.
,
Willey D.L.
,
Williams S.A.
,
Wilming L.
,
Wray P.W.
,
Young L.
,
Ashurst J.L.
,
Coulson A.
,
Blocker H.
,
Durbin R.M.
,
Sulston J.E.
,
Hubbard T.
,
Jackson M.J.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
,
Dunham I.
more...
Nature429:369-374(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 332-922 (ISOFORM 4);NUCLEOTIDE SEQUENCE [MRNA] OF 86-259 (ISOFORM 5)
tissue :
Cerebellum .
tissue :
Hippocampus .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 364-464 (ISOFORMS 1/2/3)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY PKC
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERCHAIN DISULFIDE BOND
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MYZAP
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 599-621
13.
"Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability."
Hamdan F.F.
,
Gauthier J.
,
Araki Y.
,
Lin D.T.
,
Yoshizawa Y.
,
Higashi K.
,
Park A.R.
,
Spiegelman D.
,
Dobrzeniecka S.
,
Piton A.
,
Tomitori H.
,
Daoud H.
,
Massicotte C.
,
Henrion E.
,
Diallo O.
,
Shekarabi M.
,
Marineau C.
,
Shevell M.
,
Maranda B.
,
Mitchell G.
,
Nadeau A.
,
D'Anjou G.
,
Vanasse M.
,
Srour M.
,
Lafreniere R.G.
,
Drapeau P.
,
Lacaille J.C.
,
Kim E.
,
Lee J.R.
,
Igarashi K.
,
Huganir R.L.
,
Rouleau G.A.
,
Michaud J.L.
more...
Am. J. Hum. Genet.88:306-316(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS MRD8 SER-560 INS AND LYS-662;CHARACTERIZATION OF VARIANTS MRD8 SER-560 INS AND LYS-662