Protein name:
Nitric oxide synthase, brain ;
Alternative:
NC-NOS ;Constitutive NOS ;Neuronal NOS (N-NOS;nNOS) ;NOS type I ;bNOS ;Peptidyl-cysteine S-nitrosylase NOS1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4.
Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
Subcellular Location:
Cell membrane
sarcolemma
Peripheral membrane protein
Cell projection
dendritic spine
In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
Protein Attributes:
50:
MEDHMFGVQQ | IQPNVISVRL | FKRKVGGLGF | LVKERVSKPP | VIISDLIRGG |
100:
AAEQSGLIQA | GDIILAVNGR | PLVDLSYDSA | LEVLRGIASE | THVVLILRGP |
150:
EGFTTHLETT | FTGDGTPKTI | RVTQPLGPPT | KAVDLSHQPP | AGKEQPLAVD |
200:
GASGPGNGPQ | HAYDDGQEAG | SLPHANGLAP | RPPGQDPAKK | ATRVSLQGRG |
250:
ENNELLKEIE | PVLSLLTSGS | RGVKGGAPAK | AEMKDMGIQV | DRDLDGKSHK |
300:
PLPLGVENDR | VFNDLWGKGN | VPVVLNNPYS | EKEQPPTSGK | QSPTKNGSPS |
350:
KCPRFLKVKN | WETEVVLTDT | LHLKSTLETG | CTEYICMGSI | MHPSQHARRP |
400:
EDVRTKGQLF | PLAKEFIDQY | YSSIKRFGSK | AHMERLEEVN | KEIDTTSTYQ |
450:
LKDTELIYGA | KHAWRNASRC | VGRIQWSKLQ | VFDARDCTTA | HGMFNYICNH |
500:
VKYATNKGNL | RSAITIFPQR | TDGKHDFRVW | NSQLIRYAGY | KQPDGSTLGD |
550:
PANVQFTEIC | IQQGWKPPRG | RFDVLPLLLQ | ANGNDPELFQ | IPPELVLEVP |
600:
IRHPKFEWFK | DLGLKWYGLP | AVSNMLLEIG | GLEFSACPFS | GWYMGTEIGV |
650:
RDYCDNSRYN | ILEEVAKKMN | LDMRKTSSLW | KDQALVEINI | AVLYSFQSDK |
700:
VTIVDHHSAT | ESFIKHMENE | YRCRGGCPAD | WVWIVPPMSG | SITPVFHQEM |
750:
LNYRLTPSFE | YQPDPWNTHV | WKGTNGTPTK | RRAIGFKKLA | EAVKFSAKLM |
800:
GQAMAKRVKA | TILYATETGK | SQAYAKTLCE | IFKHAFDAKV | MSMEEYDIVH |
850:
LEHETLVLVV | TSTFGNGDPP | ENGEKFGCAL | MEMRHPNSVQ | EERKSYKVRF |
900:
NSVSSYSDSQ | KSSGDGPDLR | DNFESAGPLA | NVRFSVFGLG | SRAYPHFCAF |
950:
GHAVDTLLEE | LGGERILKMR | EGDELCGQEE | AFRTWAKKVF | KAACDVFCVG |
1000:
DDVNIEKANN | SLISNDRSWK | RNKFRLTFVA | EAPELTQGLS | NVHKKRVSAA |
1050:
RLLSRQNLQS | PKSSRSTIFV | RLHTNGSQEL | QYQPGDHLGV | FPGNHEDLVN |
1100:
ALIERLEDAP | PVNQMVKVEL | LEERNTALGV | ISNWTDELRL | PPCTIFQAFK |
1150:
YYLDITTPPT | PLQLQQFASL | ATSEKEKQRL | LVLSKGLQEY | EEWKWGKNPT |
1200:
IVEVLEEFPS | IQMPATLLLT | QLSLLQPRYY | SISSSPDMYP | DEVHLTVAIV |
1250:
SYRTRDGEGP | IHHGVCSSWL | NRIQADELVP | CFVRGAPSFH | LPRNPQVPCI |
1300:
LVGPGTGIAP | FRSFWQQRQF | DIQHKGMNPC | PMVLVFGCRQ | SKIDHIYREE |
1350:
TLQAKNKGVF | RELYTAYSRE | PDKPKKYVQD | ILQEQLAESV | YRALKEQGGH |
1400:
IYVCGDVTMA | ADVLKAIQRI | MTQQGKLSAE | DAGVFISRMR | DDNRYHEDIF |
1434:
GVTLRTYEVT | NRLRSESIAF | IEESKKDTDE | VFSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
ELISA Kit for Human Nitric oxide synthase, brain
ELISA Kit for Human Nitric oxide synthase, brain
ELISA Kit for Human Nitric oxide synthase, brain
ELISA Kit for Human Nitric oxide synthase, brain
CLIA Kit for Human Nitric oxide synthase, brain
CLIA Kit for Human Nitric oxide synthase, brain
CLIA Kit for Human Nitric oxide synthase, brain
CLIA Kit for Human Nitric oxide synthase, brain
Polyclonal Antibody for Human Nitric oxide synthase, brain
Polyclonal Antibody for Human Nitric oxide synthase, brain
Polyclonal Antibody for Human Nitric oxide synthase, brain
Polyclonal Antibody for Human Nitric oxide synthase, brain
Monoclonal Antibody for Human Nitric oxide synthase, brain
Monoclonal Antibody for Human Nitric oxide synthase, brain
Monoclonal Antibody for Human Nitric oxide synthase, brain
Monoclonal Antibody for Human Nitric oxide synthase, brain
Protein for Human Nitric oxide synthase, brain
Protein for Human Nitric oxide synthase, brain
Protein for Human Nitric oxide synthase, brain
Protein for Human Nitric oxide synthase, brain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue :
Cerebellum .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Brain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Retina .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3 AND 4)
tissue :
Testis .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-228; ALA-394; ASP-725; ASP-864 AND ARG-1064
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Nature440:346-351(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 835-901 (ISOFORM 5);ALTERNATIVE SPLICING
tissue :
Skeletal muscle .