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Index > Protein center > NOS1(Gene name) > Human
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  • NOS1 (Gene name),
  • Nitric oxide synthase, brain (Protein name ),  NOS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    NOS1;
    Protein name:
    Nitric oxide synthase, brain;
    Alternative:
    NC-NOS;Constitutive NOS;Neuronal NOS(N-NOS;nNOS);NOS type I;bNOS;Peptidyl-cysteine S-nitrosylase NOS1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Forms a ternary complex with CAPON and RASD1. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with HTR4. Interacts with VAC14 (By similarity). Interacts with SLC6A4.
    Function:
    Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.
    Subcellular Location:
    Cell membrane sarcolemma Peripheral membrane protein Cell projection dendritic spine In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
    Protein Attributes:
    Sequence length:
    1434
    Sequence:
    50:
    MEDHMFGVQQ | IQPNVISVRL | FKRKVGGLGF | LVKERVSKPP | VIISDLIRGG | 
    100:
    AAEQSGLIQA | GDIILAVNGR | PLVDLSYDSA | LEVLRGIASE | THVVLILRGP | 
    150:
    EGFTTHLETT | FTGDGTPKTI | RVTQPLGPPT | KAVDLSHQPP | AGKEQPLAVD | 
    200:
    GASGPGNGPQ | HAYDDGQEAG | SLPHANGLAP | RPPGQDPAKK | ATRVSLQGRG | 
    250:
    ENNELLKEIE | PVLSLLTSGS | RGVKGGAPAK | AEMKDMGIQV | DRDLDGKSHK | 
    300:
    PLPLGVENDR | VFNDLWGKGN | VPVVLNNPYS | EKEQPPTSGK | QSPTKNGSPS | 
    350:
    KCPRFLKVKN | WETEVVLTDT | LHLKSTLETG | CTEYICMGSI | MHPSQHARRP | 
    400:
    EDVRTKGQLF | PLAKEFIDQY | YSSIKRFGSK | AHMERLEEVN | KEIDTTSTYQ | 
    450:
    LKDTELIYGA | KHAWRNASRC | VGRIQWSKLQ | VFDARDCTTA | HGMFNYICNH | 
    500:
    VKYATNKGNL | RSAITIFPQR | TDGKHDFRVW | NSQLIRYAGY | KQPDGSTLGD | 
    550:
    PANVQFTEIC | IQQGWKPPRG | RFDVLPLLLQ | ANGNDPELFQ | IPPELVLEVP | 
    600:
    IRHPKFEWFK | DLGLKWYGLP | AVSNMLLEIG | GLEFSACPFS | GWYMGTEIGV | 
    650:
    RDYCDNSRYN | ILEEVAKKMN | LDMRKTSSLW | KDQALVEINI | AVLYSFQSDK | 
    700:
    VTIVDHHSAT | ESFIKHMENE | YRCRGGCPAD | WVWIVPPMSG | SITPVFHQEM | 
    750:
    LNYRLTPSFE | YQPDPWNTHV | WKGTNGTPTK | RRAIGFKKLA | EAVKFSAKLM | 
    800:
    GQAMAKRVKA | TILYATETGK | SQAYAKTLCE | IFKHAFDAKV | MSMEEYDIVH | 
    850:
    LEHETLVLVV | TSTFGNGDPP | ENGEKFGCAL | MEMRHPNSVQ | EERKSYKVRF | 
    900:
    NSVSSYSDSQ | KSSGDGPDLR | DNFESAGPLA | NVRFSVFGLG | SRAYPHFCAF | 
    950:
    GHAVDTLLEE | LGGERILKMR | EGDELCGQEE | AFRTWAKKVF | KAACDVFCVG | 
    1000:
    DDVNIEKANN | SLISNDRSWK | RNKFRLTFVA | EAPELTQGLS | NVHKKRVSAA | 
    1050:
    RLLSRQNLQS | PKSSRSTIFV | RLHTNGSQEL | QYQPGDHLGV | FPGNHEDLVN | 
    1100:
    ALIERLEDAP | PVNQMVKVEL | LEERNTALGV | ISNWTDELRL | PPCTIFQAFK | 
    1150:
    YYLDITTPPT | PLQLQQFASL | ATSEKEKQRL | LVLSKGLQEY | EEWKWGKNPT | 
    1200:
    IVEVLEEFPS | IQMPATLLLT | QLSLLQPRYY | SISSSPDMYP | DEVHLTVAIV | 
    1250:
    SYRTRDGEGP | IHHGVCSSWL | NRIQADELVP | CFVRGAPSFH | LPRNPQVPCI | 
    1300:
    LVGPGTGIAP | FRSFWQQRQF | DIQHKGMNPC | PMVLVFGCRQ | SKIDHIYREE | 
    1350:
    TLQAKNKGVF | RELYTAYSRE | PDKPKKYVQD | ILQEQLAESV | YRALKEQGGH | 
    1400:
    IYVCGDVTMA | ADVLKAIQRI | MTQQGKLSAE | DAGVFISRMR | DDNRYHEDIF | 
    1434:
    GVTLRTYEVT | NRLRSESIAF | IEESKKDTDE | VFSS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    MIM:
    String:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Nitric oxide synthase, brain
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    Packing:
    96T
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    ELISA Kit for Human Nitric oxide synthase, brain
    Cat.:
    E0628h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Nitric oxide synthase, brain
    Cat.:
    E0628m
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Human Nitric oxide synthase, brain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, brain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, brain
    Cat.:
    U0628h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, brain
    Cat.:
    U0628r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Nitric oxide synthase, brain
    Cat.:
    U0628m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Nitric oxide synthase, brain
    Cat.:
    P0628Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nitric oxide synthase, brain
    Polyclonal Antibody for Human Nitric oxide synthase, brain
    Cat.:
    P0628Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Nitric oxide synthase, brain
    Cat.:
    P0628Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Nitric oxide synthase, brain
    Monoclonal Antibody for Human Nitric oxide synthase, brain
    Monoclonal Antibody for Human Nitric oxide synthase, brain
    Monoclonal Antibody for Human Nitric oxide synthase, brain
    Protein for Human Nitric oxide synthase, brain
    Protein for Human Nitric oxide synthase, brain
    Protein for Human Nitric oxide synthase, brain
    Protein for Human Nitric oxide synthase, brain

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    References
    1. 1.
      "Structural organization of the human neuronal nitric oxide synthase gene (NOS1)."
      Hall A.V. , Antoniou H. , Wang Y. , Cheung A.H. , Arbus A.M. , Olson S.L. , Lu W.C. , Kau C.-L. , Marsden P.A.
      J. Biol. Chem.269:33082-33090(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    2. 2.
      "Expression of two types of nitric oxide synthase mRNA in human neuroblastoma cell lines."
      Fujisawa H. , Ogura T. , Kurashima Y. , Yokoyama T. , Yamashita J. , Esumi H.
      J. Neurochem.63:140-145(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Cerebellum.
    3. 3.
      "Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle."
      Nakane M. , Schmidt H.H.H.W. , Pollock J.S. , Foerstermann U. , Murad F.
      FEBS Lett.316:175-180(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Brain.
    4. 4.
      "Neuronal isoform of nitric oxide synthase is expressed at low levels in human retina."
      Park C.-S. , Gianotti C. , Park R. , Krishna G.
      Cell. Mol. Neurobiol.16:499-515(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Retina.
    5. 5.
      "A novel, testis-specific mRNA transcript encoding an NH2-terminal truncated nitric-oxide synthase."
      Wang Y. , Goligorsky M.S. , Lin M. , Wilcox J.N. , Marsden P.A.
      J. Biol. Chem.272:11392-11401(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3 AND 4)
      tissue: Testis.
    6. 6.
      NIEHS SNPs program
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-228; ALA-394; ASP-725; ASP-864 AND ARG-1064
    7. 7.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "Isolation and characterization of a novel, human neuronal nitric oxide synthase cDNA."
      Larsson B. , Phillips S.C.
      Biochem. Biophys. Res. Commun.251:898-902(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 835-901 (ISOFORM 5);ALTERNATIVE SPLICING
      tissue: Skeletal muscle.
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