Protein name:
Nitric oxide synthase, brain ;
Alternative:
NC-NOS ;Constitutive NOS ;Neuronal NOS (N-NOS;nNOS) ;NOS type I ;bNOS ;Peptidyl-cysteine S-nitrosylase NOS1 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer. Forms a ternary complex with CAPON and SYN1. Interacts with ZDHHC23. Interacts with NOSIP; which may impair its synaptic location (By similarity). Interacts with DLG4; the interaction possibly being prevented by the association between NOS1 and CAPON. Interacts with HTR4. Forms a ternary complex with CAPON and RASD1. Interacts with VAC14 (By similarity). Interacts with SLC6A4.
Function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex.
Subcellular Location:
Cell membrane
sarcolemma
Peripheral membrane protein
Cell projection
dendritic spine
In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex. In neurons, enriched in dendritic spines.
Protein Attributes:
50:
MEEHTFGVQQ | IQPNVISVRL | FKRKVGGLGF | LVKERVSKPP | VIISDLIRGG |
100:
AAEQSGLIQA | GDIILAVNDR | PLVDLSYDSA | LEVLRGIASE | THVVLILRGP |
150:
EGFTTHLETT | FTGDGTPKTI | RVTQPLGTPT | KAVDLSRQPS | ASKDQPLAVD |
200:
RVPGPSNGPQ | HAQGRGQGAG | SVSQANGVAI | DPTMKNTKAN | LQDSGEQDEL |
250:
LKEIEPVLSI | LTGGGKAVNR | GGPAKAEMKD | TGIQVDRDLD | GKLHKAPPLG |
300:
GENDRVFNDL | WGKGNVPVVL | NNPYSENEQS | PASGKQSPTK | NGSPSRCPRF |
350:
LKVKNWETDV | VLTDTLHLKS | TLETGCTEQI | CMGSIMLPSH | HIRKSEDVRT |
400:
KDQLFPLAKE | FLDQYYSSIK | RFGSKAHMDR | LEEVNKEIES | TSTYQLKDTE |
450:
LIYGAKHAWR | NASRCVGRIQ | WSKLQVFDAR | DCTTAHGMFN | YICNHVKYAT |
500:
NKGNLRSAIT | IFPQRTDGKH | DFRVWNSQLI | RYAGYKQPDG | STLGDPANVE |
550:
FTEICIQQGW | KPPRGRFDVL | PLLLQANGND | PELFQIPPEL | VLEVPIRHPK |
600:
FDWFKDLGLK | WYGLPAVSNM | LLEIGGLEFS | ACPFSGWYMG | TEIGVRDYCD |
650:
NSRYNILEEV | AKKMDLDMRK | TSSLWKDQAL | VEINIAVLYS | FQSDKVTIVD |
700:
HHSATESFIK | HMENEYRCRG | GCPADWVWIV | PPMSGSITPV | FHQEMLNYRL |
750:
TPSFEYQPDP | WNTHVWKGTN | GTPTKRRAIG | FKKLAEAVKF | SAKLMGQAMA |
800:
KRVKATILYA | TETGKSQAYA | KTLCEIFKHA | FDAKAMSMEE | YDIVHLEHEA |
850:
LVLVVTSTFG | NGDPPENGEK | FGCALMEMRH | PNSVQEERKS | YKVRFNSVSS |
900:
YSDSRKSSGD | GPDLRDNFES | TGPLANVRFS | VFGLGSRAYP | HFCAFGHAVD |
950:
TLLEELGGER | ILKMREGDEL | CGQEEAFRTW | AKKVFKAACD | VFCVGDDVNI |
1000:
EKANNSLISN | DRSWKRNKFR | LTYVAEAPEL | TQGLSNVHKK | RVSAARLLSR |
1050:
QNLQSPKSSR | STIFVRLHTN | GNQELQYQPG | DHLGVFPGNH | EDLVNALIER |
1100:
LEDAPPANHV | VKVEMLEERN | TALGVISNWK | DESRLPPCTI | FQAFKYYLDI |
1150:
TTPPTPLQLQ | QFASLATNEK | EKQRLLVLSK | GLQEYEEWKW | GKNPTMVEVL |
1200:
EEFPSIQMPA | TLLLTQLSLL | QPRYYSISSS | PDMYPDEVHL | TVAIVSYHTR |
1250:
DGEGPVHHGV | CSSWLNRIQA | DDVVPCFVRG | APSFHLPRNP | QVPCILVGPG |
1300:
TGIAPFRSFW | QQRQFDIQHK | GMNPCPMVLV | FGCRQSKIDH | IYREETLQAK |
1350:
NKGVFRELYT | AYSREPDRPK | KYVQDVLQEQ | LAESVYRALK | EQGGHIYVCG |
1400:
DVTMAADVLK | AIQRIMTQQG | KLSEEDAGVF | ISRLRDDNRY | HEDIFGVTLR |
1429:
TYEVTNRLRS | ESIAFIEESK | KDTDEVFSS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
ELISA Kit for Mouse Nitric oxide synthase, brain
ELISA Kit for Mouse Nitric oxide synthase, brain
ELISA Kit for Mouse Nitric oxide synthase, brain
ELISA Kit for Mouse Nitric oxide synthase, brain
CLIA Kit for Mouse Nitric oxide synthase, brain
CLIA Kit for Mouse Nitric oxide synthase, brain
CLIA Kit for Mouse Nitric oxide synthase, brain
CLIA Kit for Mouse Nitric oxide synthase, brain
Polyclonal Antibody for Mouse Nitric oxide synthase, brain
Polyclonal Antibody for Mouse Nitric oxide synthase, brain
Polyclonal Antibody for Mouse Nitric oxide synthase, brain
Polyclonal Antibody for Mouse Nitric oxide synthase, brain
Monoclonal Antibody for Mouse Nitric oxide synthase, brain
Monoclonal Antibody for Mouse Nitric oxide synthase, brain
Monoclonal Antibody for Mouse Nitric oxide synthase, brain
Monoclonal Antibody for Mouse Nitric oxide synthase, brain
Protein for Mouse Nitric oxide synthase, brain
Protein for Mouse Nitric oxide synthase, brain
Protein for Mouse Nitric oxide synthase, brain
Protein for Mouse Nitric oxide synthase, brain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS N-NOS-1 AND N-NOS-2)
strain :
BALB/c .
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM NNOS MU)
tissue :
Skeletal muscle .
3.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1320-1429
strain :
C57BL/6J .
tissue :
Spinal ganglion .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS NNOS BETA; NNOS GAMMA AND NNOS MU)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DLG4
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RASD1 AND CAPON
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HTR4
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION AS NITROSYLASE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SLC6A4
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 725-747 IN COMPLEX WITH CALMODULIN