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Index > Protein center > NQO2(Gene name) > Human
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  • NQO2 (Gene name),
  • Ribosyldihydronicotinamide dehydrogenase [quinone] (Protein name ),  NQO2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    NQO2(NMOR2);
    Protein name:
    Ribosyldihydronicotinamide dehydrogenase [quinone];
    Alternative:
    NRH:quinone oxidoreductase 2;NRH dehydrogenase [quinone] 2;Quinone reductase 2(QR2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    231
    Sequence:
    50:
    MAGKKVLIVY | AHQEPKSFNG | SLKNVAVDEL | SRQGCTVTVS | DLYAMNLEPR | 
    100:
    ATDKDITGTL | SNPEVFNYGV | ETHEAYKQRS | LASDITDEQK | KVREADLVIF | 
    150:
    QFPLYWFSVP | AILKGWMDRV | LCQGFAFDIP | GFYDSGLLQG | KLALLSVTTG | 
    200:
    GTAEMYTKTG | VNGDSRYFLW | PLQHGTLHFC | GFKVLAPQIS | FAPEIASEEE | 
    231:
    RKGMVAAWSQ | RLQTIWKEEP | IPCTAHWHFG | Q
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    E15059h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    E15059r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    E15059m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    U15059m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    U15059h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    U15059r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    P15059Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    P15059Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Cat.:
    P15059Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Monoclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Monoclonal Antibody for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein for Human Ribosyldihydronicotinamide dehydrogenase [quinone]
    Protein for Human Ribosyldihydronicotinamide dehydrogenase [quinone]

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6."
      Jaiswal A.K. , Burnett P. , Adesnik M. , McBride O.W.
      Biochemistry29:1899-1906(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PHE-47
      tissue: Liver.
    2. 2.
      "Human NAD(P)H:quinone oxidoreductase 2. Gene structure, activity, and tissue-specific expression."
      Jaiswal A.K.
      J. Biol. Chem.269:14502-14508(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-47
      tissue: Liver.
    3. 3.
      "Human NRH:quinone oxidoreductase 2, complete genomic sequence."
      Iida A. , Osawa S. , Kitamura Y. , Kitamoto T. , Koyama K. , Nakamura Y.
      Submitted (2000-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-47
    4. 4.
      NIEHS SNPs program
      Submitted (2004-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-16; GLY-29; PHE-47; ASP-58 AND ALA-184
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PHE-47
      tissue: Cerebellum.
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT PHE-47
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PHE-47
      tissue: Brain.
    9. 9.
      "Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase."
      Wu K. , Knox R. , Sun X.Z. , Joseph P. , Jaiswal A.K. , Zhang D. , Deng P.S.-K. , Chen S.
      Arch. Biochem. Biophys.347:221-228(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;BIOPHYSICOCHEMICAL PROPERTIES
    10. 10.
      "Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)."
      Zhao Q. , Yang X.L. , Holtzclaw W.D. , Talalay P.
      Proc. Natl. Acad. Sci. U.S.A.94:1669-1674(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    12. 12.
      "Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines."
      Kwiek J.J. , Haystead T.A.J. , Rudolph J.
      Biochemistry43:4538-4547(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80 AND SER-197;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Crystal structure of human quinone reductase type 2, a metalloflavoprotein."
      Foster C.E. , Bianchet M.A. , Talalay P. , Zhao Q. , Amzel L.M.
      Biochemistry38:9881-9886(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
    16. 16.
      "Crystal structure of quinone reductase 2 in complex with resveratrol."
      Buryanovskyy L. , Fu Y. , Boyd M. , Ma Y. , Hsieh T.-C. , Wu J.M. , Zhang Z.
      Biochemistry43:11417-11426(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH RESVERATROL
    17. 17.
      "Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954."
      Fu Y. , Buryanovskyy L. , Zhang Z.
      Biochem. Biophys. Res. Commun.336:332-338(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) IN COMPLEX WITH CB1954;MUTAGENESIS OF ASN-162
    18. 18.
      "Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2."
      Calamini B. , Santarsiero B.D. , Boutin J.A. , Mesecar A.D.
      Biochem. J.413:81-91(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH MELATONIN AND FAD;FUNCTION;SUBUNIT;ENZYME REGULATION
    19. 19.
      "Quinone reductase 2 is a catechol quinone reductase."
      Fu Y. , Buryanovskyy L. , Zhang Z.
      J. Biol. Chem.283:23829-23835(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEXES WITH DOPAMINE AND ADRENOCHROME;ENZYME ACTIVITY
    20. 20.
      "The structure of the leukemia drug imatinib bound to human quinone reductase 2 (NQO2)."
      Winger J.A. , Hantschel O. , Superti-Furga G. , Kuriyan J.
      BMC Struct. Biol.9:7-7(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH ZINC IONS; FAD AND IMATINIB
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