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Index > Protein center > NR1H2(Gene name) > Human
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  • NR1H2 (Gene name),
  • Oxysterols receptor LXR-beta (Protein name ),  NR1H2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    NR1H2(LXRB;NER;UNR);
    Protein name:
    Oxysterols receptor LXR-beta;
    Alternative:
    Nuclear receptor NER;Liver X receptor beta;Ubiquitously-expressed nuclear receptor;Nuclear receptor subfamily 1 group H member 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a heterodimer with RXR.
    Function:
    Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    460
    Sequence:
    50:
    MSSPTTSSLD | TPLPGNGPPQ | PGAPSSSPTV | KEEGPEPWPG | GPDPDVPGTD | 
    100:
    EASSACSTDW | VIPDPEEEPE | RKRKKGPAPK | MLGHELCRVC | GDKASGFHYN | 
    150:
    VLSCEGCKGF | FRRSVVRGGA | RRYACRGGGT | CQMDAFMRRK | CQQCRLRKCK | 
    200:
    EAGMREQCVL | SEEQIRKKKI | RKQQQESQSQ | SQSPVGPQGS | SSSASGPGAS | 
    250:
    PGGSEAGSQG | SGEGEGVQLT | AAQELMIQQL | VAAQLQCNKR | SFSDQPKVTP | 
    300:
    WPLGADPQSR | DARQQRFAHF | TELAIISVQE | IVDFAKQVPG | FLQLGREDQI | 
    350:
    ALLKASTIEI | MLLETARRYN | HETECITFLK | DFTYSKDDFH | RAGLQVEFIN | 
    400:
    PIFEFSRAMR | RLGLDDAEYA | LLIAINIFSA | DRPNVQEPGR | VEALQQPYVE | 
    450:
    ALLSYTRIKR | PQDQLRFPRM | LMKLVSLRTL | SSVHSEQVFA | LRLQDKKLPP | 
    460:
    LLSEIWDVHE | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    E0212h
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    96T
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    ELISA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    E0212r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    E0212m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    E0212b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    U0212h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    U0212m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    U0212b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Oxysterols receptor LXR-beta
    Cat.:
    U0212r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oxysterols receptor LXR-beta
    Polyclonal Antibody for Human Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Oxysterols receptor LXR-beta
    Cat.:
    P0212Rb-h
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Oxysterols receptor LXR-beta
    Monoclonal Antibody for Human Oxysterols receptor LXR-beta
    Monoclonal Antibody for Human Oxysterols receptor LXR-beta
    Monoclonal Antibody for Human Oxysterols receptor LXR-beta
    Protein for Human Oxysterols receptor LXR-beta
    Protein for Human Oxysterols receptor LXR-beta
    Protein for Human Oxysterols receptor LXR-beta
    Protein for Human Oxysterols receptor LXR-beta

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    References
    1. 1.
      "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor."
      Shinar D.M. , Endo N. , Rutledge S.J. , Vogel R. , Rodan G.A. , Schmidt A.
      Gene147:273-276(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Osteosarcoma.
      tissue: Skin.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Mammary gland.
    3. 3.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Blood.
      tissue: Brain.
      tissue: Placenta.
      tissue: Uterus.
    5. 5.
      "Ubiquitous receptor: a novel receptor that modulates gene activation by retinoic acid and thyroid hormone receptors."
      Song C. , Konkontis J.M. , Hiipakka R.A. , Liao S.
      Submitted (1994-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-460 (ISOFORM 1)
    6. 6.
      "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands."
      Farnegardh M. , Bonn T. , Sun S. , Ljunggren J. , Ahola H. , Wilhelmsson A. , Gustafsson J.-A. , Carlquist M.
      J. Biol. Chem.278:38821-38828(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 208-460 IN COMPLEX WITH SYNTHETIC LIGANDS
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