Protein name:
Oncostatin-M (OSM) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Function:
Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells (By similarity). Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRAQPPPRTL | LSLALALLFL | SMSWAKRGCS | SSSPKLLSQL | KSQANITGNT |
100:
ASLLEPYILH | QNLNTLTLRA | ACTEHPVAFP | SEDMLRQLSK | PDFLSTVHAT |
150:
LGRVWHQLGA | FRQQFPKIQD | FPELERARQN | IQGIRNNVYC | MARLLHPPLE |
200:
IPEPTQADSG | TSRPTTTAPG | IFQIKIDSCR | FLWGYHRFMG | SVGRVFEEWG |
239:
DGSRRSRRHS | PLWAWLKGDH | RIRPSRSSQS | AMLRSLVPR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
Bovine
Polyclonal Antibody for Rat OSM
Polyclonal Antibody for Rat OSM
Polyclonal Antibody for Rat OSM
Polyclonal Antibody for Rat OSM
Monoclonal Antibody for Rat OSM
Monoclonal Antibody for Rat OSM
Monoclonal Antibody for Rat OSM
Monoclonal Antibody for Rat OSM
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Oncostatin M inhibits proliferation of rat oval cells, OC15-5, inducing differentiation into hepatocytes."
Okaya A.
,
Kitanaka J.
,
Kitanaka N.
,
Satake M.
,
Kim Y.
,
Terada K.
,
Sugiyama T.
,
Takemura M.
,
Fujimoto J.
,
Terada N.
,
Miyajima A.
,
Tsujimura T.
Am. J. Pathol.166:709-719(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY