HCRT ELISA Kit for Human(Homo sapiens) | EIAab.comHCRT ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HCRT(Gene name) > Human

HCRT (Gene name),

Orexin (Protein name ), OREX_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

HCRT(OX;PPORX;PPOX);

Protein name:

Orexin;

Alternative:

Hypocretin(Hcrt);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.

Subcellular Location:

Rough endoplasmic reticulum Cytoplasmic vesicle Cell junction synapse Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.

Protein Attributes:

Sequence length:

131

Sequence:

50:

100:

131:

AGAEPAPRPC | LGRRCSAPAA | ASVAPGGQSG | I

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.158348

STRING:

9606.ENSP00000293330

KEGG:

hsa:3060

Pfam:

PF02072

SMR:

O43612

MIM:

161400

String:

O43612

Uniprot:

O43612

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ELISA Kit for Human Orexin

Cat.:

E0777h

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Manual:

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Packing:

96T

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ELISA Kit for Human Orexin

Cat.:

E0777r

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Packing:

96T

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ELISA Kit for Human Orexin

Cat.:

E0777m

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Packing:

96T

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ELISA Kit for Human Orexin

MSDS:

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ELISA Kit for Human Orexin

Cat.:

E0777p

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MSDS:

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Packing:

96T

ELISA Kit for Human Orexin

Cat.:

E0777d

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Packing:

96T

CLIA Kit for Human Orexin

Cat.:

U0777p

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MSDS:

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Packing:

96T

CLIA Kit for Human Orexin

Cat.:

U0777r

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MSDS:

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Packing:

96T

CLIA Kit for Human Orexin

Cat.:

U0777h

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MSDS:

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Packing:

96T

CLIA Kit for Human Orexin

Cat.:

U0777d

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MSDS:

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Packing:

96T

CLIA Kit for Human Orexin

MSDS:

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CLIA Kit for Human Orexin

Cat.:

U0777m

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Orexin

Cat.:

P0777Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Orexin

Cat.:

P0777Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Orexin

Cat.:

P0777Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Orexin

Protein for Human Orexin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior."
Sakurai T. , Amemiya A. , Ishii M. , Matsuzaki I. , Chemelli R.M. , Tanaka H. , Williams S.C. , Richardson J.A. , Kozlowski G.P. , Wilson S. , Arch J.R.S. , Buckingham R.E. , Haynes A.C. , Carr S.A. , Annan R.S. , McNulty D.E. , Liu W.-S. , Terrett J.A. , more...
Cell92:573-585(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure and function of human prepro-orexin gene."
Sakurai T. , Moriguchi T. , Furuya K. , Kajiwara N. , Nakamura T. , Yanagisawa M. , Goto K.
J. Biol. Chem.274:17771-17776(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B."
Lee J.-H. , Bang E. , Chae K.-J. , Kim J.-Y. , Lee D.W. , Lee W.
Eur. J. Biochem.266:831-839(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 70-97
4.

"Hypocretin/orexin, sleep and narcolepsy."
Hungs M. , Mignot E.
Bioessays23:397-408(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
5.

"To eat or to sleep? Orexin in the regulation of feeding and wakefulness."
Willie J.T. , Chemelli R.M. , Sinton C.M. , Yanagisawa M.
Annu. Rev. Neurosci.24:429-458(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
6.

"Solution structure of human orexin-A: regulator of appetite and wakefulness."
Kim H.Y. , Hong E. , Kim J.I. , Lee W.
J. Biochem. Mol. Biol.37:565-573(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 34-66;DISULFIDE BONDS
7.

"Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy."
Siebold C. , Hansen B.E. , Wyer J.R. , Harlos K. , Esnouf R.E. , Svejgaard A. , Bell J.I. , Strominger J.L. , Jones E.Y. , Fugger L.
Proc. Natl. Acad. Sci. U.S.A.101:1999-2004(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-12 IN COMPLEX OF HLA-DQA1/HLA-DQB1 HETERODIMER (HLA-DQ0602)
8.

"Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor."
Takai T. , Takaya T. , Nakano M. , Akutsu H. , Nakagawa A. , Aimoto S. , Nagai K. , Ikegami T.
J. Pept. Sci.12:443-454(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 35-66;DISULFIDE BONDS
9.

"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains."
Peyron C. , Faraco J. , Rogers W. , Ripley B. , Overeem S. , Charnay Y. , Nevsimalova S. , Aldrich M. , Reynolds D. , Albin R. , Li R. , Hungs M. , Pedrazzoli M. , Padigaru M. , Kucherlapati M. , Fan J. , Maki R. , Lammers G.J. , more...
Nat. Med.6:991-997(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT NRCLP1 ARG-16

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