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Index > Protein center > Pcsk9(Gene name) > Mouse
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  • Pcsk9 (Gene name),
  • Proprotein convertase subtilisin/kexin type 9 (Protein name ),  PCSK9_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Pcsk9(Narc1);
    Protein name:
    Proprotein convertase subtilisin/kexin type 9;
    Alternative:
    Proprotein convertase 9(PC9);Neural apoptosis-regulated convertase 1(NARC-1);Subtilisin/kexin-like protease PC9;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    The precursor protein but not the mature protein may form multimers.
    Function:
    May play a role in cholesterol homeostasis (By similarity). May be implicated in the differentiation of cortical neurons and also in hepatic cells proliferation.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    694
    Sequence:
    50:
    MGTHCSAWLR | WPLLPLLPPL | LLLLLLLCPT | GAGAQDEDGD | YEELMLALPS | 
    100:
    QEDGLADEAA | HVATATFRRC | SKEAWRLPGT | YIVVLMEETQ | RLQIEQTAHR | 
    150:
    LQTRAARRGY | VIKVLHIFYD | LFPGFLVKMS | SDLLGLALKL | PHVEYIEEDS | 
    200:
    FVFAQSIPWN | LERIIPAWHQ | TEEDRSPDGS | SQVEVYLLDT | SIQGAHREIE | 
    250:
    GRVTITDFNS | VPEEDGTRFH | RQASKCDSHG | THLAGVVSGR | DAGVAKGTSL | 
    300:
    HSLRVLNCQG | KGTVSGTLIG | LEFIRKSQLI | QPSGPLVVLL | PLAGGYSRIL | 
    350:
    NAACRHLART | GVVLVAAAGN | FRDDACLYSP | ASAPEVITVG | ATNAQDQPVT | 
    400:
    LGTLGTNFGR | CVDLFAPGKD | IIGASSDCST | CFMSQSGTSQ | AAAHVAGIVA | 
    450:
    RMLSREPTLT | LAELRQRLIH | FSTKDVINMA | WFPEDQQVLT | PNLVATLPPS | 
    500:
    THETGGQLLC | RTVWSAHSGP | TRTATATARC | APEEELLSCS | SFSRSGRRRG | 
    550:
    DWIEAIGGQQ | VCKALNAFGG | EGVYAVARCC | LVPRANCSIH | NTPAARAGLE | 
    600:
    THVHCHQKDH | VLTGCSFHWE | VEDLSVRRQP | ALRSRRQPGQ | CVGHQAASVY | 
    650:
    ASCCHAPGLE | CKIKEHGISG | PSEQVTVACE | AGWTLTGCNV | LPGASLTLGA | 
    694:
    YSVDNLCVAR | VHDTARADRT | SGEATVAAAI | CCRSRPSAKA | SWVQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    E0307h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    E0307m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    E0307r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    U0307h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    U0307m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    U0307r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    P0307Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    P0307Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Cat.:
    P0307Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Monoclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Monoclonal Antibody for Mouse Proprotein convertase subtilisin/kexin type 9
    Protein for Mouse Proprotein convertase subtilisin/kexin type 9
    Protein for Mouse Proprotein convertase subtilisin/kexin type 9
    Protein for Mouse Proprotein convertase subtilisin/kexin type 9

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    Linearity
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    References
    1. 1.
      "Narc-1, novel subtilase-like homologs."
      Chiang L.W.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
    2. 2.
      "Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice."
      Maxwell K.N. , Soccio R.E. , Duncan E.M. , Sehayek E. , Breslow J.L.
      J. Lipid Res.44:2109-2119(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
      strain: C57BL/6.
      tissue: Liver.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Liver.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Eye.
    6. 6.
      "The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation."
      Seidah N.G. , Benjannet S. , Wickham L. , Marcinkiewicz J. , Jasmin S.B. , Stifani S. , Basak A. , Prat A. , Chretien M.
      Proc. Natl. Acad. Sci. U.S.A.100:928-933(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF PROPEPTIDE CLEAVAGE SITE;CHARACTERIZATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: AUTOCATALYTIC CLEAVAGE SITE
    8. 8.
      "PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans."
      Dewpura T. , Raymond A. , Hamelin J. , Seidah N.G. , Mbikay M. , Chretien M. , Mayne J.
      FEBS J.275:3480-3493(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-50;IDENTIFICATION BY MASS SPECTROMETRY
    9. 9.
      "Proprotein convertase subtilisin/kexin type 9 interacts with apolipoprotein B and prevents its intracellular degradation, irrespective of the low-density lipoprotein receptor."
      Sun H. , Samarghandi A. , Zhang N. , Yao Z. , Xiong M. , Teng B.B.
      Arterioscler. Thromb. Vasc. Biol.32:1585-1595(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling."
      Kysenius K. , Muggalla P. , Maetlik K. , Arumaee U. , Huttunen H.J.
      Cell. Mol. Life Sci.69:1903-1916(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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