Cd274 ELISA Kit for Mouse(Mus musculus) | EIAab.comCd274 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Cd274 (Gene name),

Programmed cell death 1 ligand 1 (Protein name ), PD1L1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Cd274(B7h1;Pdcd1l1;Pdcd1lg1;Pdl1);

Protein name:

Programmed cell death 1 ligand 1(PD-L1;PDCD1 ligand 1;Programmed death ligand 1);

Alternative:

B7 homolog 1(B7-H1);

CD:

CD274;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PDCD1.

Function:

Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

290

Sequence:

50:

MRIFAGIIFT | ACCHLLRAFT | ITAPKDLYVV | EYGSNVTMEC | RFPVERELDL |

100:

LALVVYWEKE | DEQVIQFVAG | EEDLKPQHSN | FRGRASLPKD | QLLKGNAALQ |

150:

ITDVKLQDAG | VYCCIISYGG | ADYKRITLKV | NAPYRKINQR | ISVDPATSEH |

200:

ELICQAEGYP | EAEVIWTNSD | HQPVSGKRSV | TTSRTEGMLL | NVTSSLRVNA |

250:

TANDVFYCTF | WRSQPGQNHT | AELIIPELPA | THPPQNRTHW | VLLGSILLFL |

290:

IVVSTVLLFL | RKQVRMLDVE | KCGVEDTSSK | NRNDTQFEET |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Pfam:

SMR:

KEGG:

UniGene:

Uniprot:

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ELISA Kit for Mouse PD-L1

Cat.:

E0513h

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96T

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ELISA Kit for Mouse PD-L1

Cat.:

E0513m

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96T

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CLIA Kit for Mouse PD-L1

Cat.:

U0513h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PD-L1

Cat.:

U0513m

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96T

Polyclonal Antibody for Mouse PD-L1

Cat.:

P0513Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PD-L1

Cat.:

P0513Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse PD-L1

Monoclonal Antibody for Mouse PD-L1

Protein for Mouse PD-L1

Protein for Mouse PD-L1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.7%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.1%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Recovery was determined by spiking various levels of PD1L1 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	104	95-106
Plasma	102	93-105

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of PD1L1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	98-110%	97-109%	100-106%	98-108%
EDTA plasma(n=5)	95-109%	97-108%	99-106%	95-107%
heparin plasma(n=5)	96-106%	94-109%	98-107%	97-106%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation."
Freeman G.J. , Long A.J. , Iwai Y. , Bourque K. , Chernova T. , Nishimura H. , Fitz L.J. , Malenkovich N. , Okazaki T. , Byrne M.C. , Horton H.F. , Fouser L. , Carter L. , Ling V. , Bowman M.R. , Carreno B.M. , Collins M. , Wood C.R. , more...
J. Exp. Med.192:1027-1034(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH PDCD1;TISSUE SPECIFICITY;INDUCTION
tissue: Spleen.
2.

"B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function."
Tamura H. , Dong H. , Zhu G. , Sica G.L. , Flies D.B. , Tamada K. , Chen L.
Blood97:1809-1816(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;INDUCTION
strain: C57BL/6.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: CD-1.
tissue: Neural stem cell.
4.

"PD-L2 is a second ligand for PD-1 and inhibits T cell activation."
Latchman Y. , Wood C.R. , Chernova T. , Chaudhary D. , Borde M. , Chernova I. , Iwai Y. , Long A.J. , Brown J.A. , Nunes R. , Greenfield E.A. , Bourque K. , Boussiotis V.A. , Carter L.L. , Carreno B.M. , Malenkovich N. , Nishimura H. , Okazaki T. , more...
Nat. Immunol.2:261-268(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction."
Wang S. , Bajorath J. , Flies D.B. , Dong H. , Honjo T. , Chen L.
J. Exp. Med.197:1083-1091(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LEU-27; GLU-31; SER-34; THR-37; ASP-49; TYR-56; GLU-58; GLU-62; PHE-67; ALA-69; GLU-72; LYS-75; LYS-89; ALA-98; CYS-113; ILE-115; SER-117; LYS-124; ILE-126 AND LYS-129

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