Pecam1 ELISA Kit for Mouse(Mus musculus) | EIAab.comPecam1 ELISA Kit for Mouse(Mus musculus)

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Pecam1 (Gene name),

Platelet endothelial cell adhesion molecule (Protein name ), PECA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pecam1(Pecam;Pecam-1);

Protein name:

Platelet endothelial cell adhesion molecule(PECAM-1);

Alternative:

CD:

CD31;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with PTPN11; Tyr-702 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ.

Function:

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Modulates BDKRB2 activation (By similarity). Induces susceptibility to atherosclerosis.

Subcellular Location:

Membrane Single-pass type I membrane protein Cell junction Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells.

Protein Attributes:

Sequence length:

727

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

727:

VYSEIRKVDP | NLMENRYSRT | EGSLNGT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q08481

UniGene:

Mm.343951

SMR:

Q08481

KEGG:

mmu:18613

STRING:

10090.ENSMUSP00000067111

Uniprot:

Q08481

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ELISA Kit for Mouse PECAM-1

Cat.:

E0363r

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96T

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ELISA Kit for Mouse PECAM-1

Cat.:

E0363h

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96T

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ELISA Kit for Mouse PECAM-1

Cat.:

E0363p

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96T

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ELISA Kit for Mouse PECAM-1

Cat.:

E0363b

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Packing:

96T

ELISA Kit for Mouse PECAM-1

Cat.:

E0363m

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Packing:

96T

CLIA Kit for Mouse PECAM-1

Cat.:

U0363m

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Packing:

96T

CLIA Kit for Mouse PECAM-1

Cat.:

U0363h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse PECAM-1

Cat.:

U0363r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse PECAM-1

Cat.:

U0363b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PECAM-1

Cat.:

U0363p

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Packing:

96T

Polyclonal Antibody for Mouse PECAM-1

Cat.:

P0363Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PECAM-1

Cat.:

P0363Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PECAM-1

Cat.:

P0363Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse PECAM-1

Protein for Mouse PECAM-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Molecular cloning and adhesive properties of murine platelet/endothelial cell adhesion molecule 1."
Xie Y. , Muller W.A.
Proc. Natl. Acad. Sci. U.S.A.90:5569-5573(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
tissue: Lung.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
strain: C57BL/6J.
tissue: Stomach.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6.
strain: FVB/N.
tissue: Mammary tumor.
6.

"Association of murine CD31 with transmigrating lymphocytes following antigenic stimulation."
Bogen S.A. , Baldwin H.S. , Watkins S.C. , Albelda S.M. , Abbas A.K.
Am. J. Pathol.141:843-854(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-26
tissue: Heart.
7.

"Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation."
Udell C.M. , Samayawardhena L.A. , Kawakami Y. , Kawakami T. , Craig A.W.
J. Biol. Chem.281:20949-20957(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-679 AND TYR-702 BY FES AND FER;MUTAGENESIS OF TYR-679; TYR-702 AND TYR-717
8.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-702;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
9.

"PECAM-1 is a critical mediator of atherosclerosis."
Stevens H.Y. , Melchior B. , Bell K.S. , Yun S. , Yeh J.C. , Frangos J.A.
Dis. Model. Mech.1:175-181(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
10.

"An alternatively spliced isoform of PECAM-1 is expressed at high levels in human and murine tissues, and suggests a novel role for the C-terminus of PECAM-1 in cytoprotective signaling."
Bergom C. , Paddock C. , Gao C. , Holyst T. , Newman D.K. , Newman P.J.
J. Cell Sci.121:1235-1242(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 2 AND 3);TISSUE SPECIFICITY
11.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-74; ASN-141; ASN-360; ASN-424 AND ASN-540

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