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Index > Protein center > Pdgfra(Gene name) > Mouse
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  • Pdgfra (Gene name),
  • Alpha-type platelet-derived growth factor receptor (Protein name ),  PGFRA_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Pdgfra;
    Protein name:
    Alpha-type platelet-derived growth factor receptor(PDGF-R-alpha);
    Alternative:
    Platelet-derived growth factor alpha receptor;CD140 antigen-like family member A;CD140 antigen-like family member A;Alpha-type platelet-derived growth factor receptor;
    CD:
    CD140a;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720. Interacts with the SH2 domain of SHF via phosphorylated Tyr-720.
    Function:
    Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1089
    Sequence:
    50:
    MGTSHQVFLV | LSCLLTGPGL | ISCQLLLPSI | LPNENEKIVQ | LNSSFSLRCV | 
    100:
    GESEVSWQHP | MSEEDDPNVE | IRSEENNSGL | FVTVLEVVNA | SAAHTGWYTC | 
    150:
    YYNHTQTDES | EIEGRHIYIY | VPDPDMAFVP | LGMTDSLVIV | EEDDSAIIPC | 
    200:
    RTTDPETQVT | LHNNGRLVPA | SYDSRQGFNG | TFSVGPYICE | ATVKGRTFKT | 
    250:
    SEFNVYALKA | TSELNLEMDA | RQTVYKAGET | IVVTCAVFNN | EVVDLQWTYP | 
    300:
    GEVRNKGITM | LEEIKLPSIK | LVYTLTVPKA | TVKDSGEYEC | AARQATKEVK | 
    350:
    EMKRVTISVH | EKGFVEIEPT | FGQLEAVNLH | EVREFVVEVQ | AYPTPRISWL | 
    400:
    KDNLTLIENL | TEITTDVQKS | QETRYQSKLK | LIRAKEEDSG | HYTIIVQNED | 
    450:
    DVKSYTFELS | TLVPASILDL | VDDHHGSGGG | QTVRCTAEGT | PLPEIDWMIC | 
    500:
    KHIKKCNNDT | SWTVLASNVS | NIITELPRRG | RSTVEGRVSF | AKVEETIAVR | 
    550:
    CLAKNNLSVV | ARELKLVAPT | LRSELTVAAA | VLVLLVIVIV | SLIVLVVIWK | 
    600:
    QKPRYEIRWR | VIESISPDGH | EYIYVDPMQL | PYDSRWEFPR | DGLVLGRILG | 
    650:
    SGAFGKVVEG | TAYGLSRSQP | VMKVAVKMLK | PTARSSEKQA | LMSELKIMTH | 
    700:
    LGPHLNIVNL | LGACTKSGPI | YIITEYCFYG | DLVNYLHKNR | DSFMSQHPEK | 
    750:
    PKKDLDIFGL | NPADESTRSY | VILSFENNGD | YMDMKQADTT | QYVPMLERKE | 
    800:
    VSKYSDIQRS | LYDRPASYKK | KSMLDSEVKN | LLSDDDSEGL | TLLDLLSFTY | 
    850:
    QVARGMEFLA | SKNCVHRDLA | ARNVLLAQGK | IVKICDFGLA | RDIMHDSNYV | 
    900:
    SKGSTFLPVK | WMAPESIFDN | LYTTLSDVWS | YGILLWEIFS | LGGTPYPGMM | 
    950:
    VDSTFYNKIK | SGYRMAKPDH | ATSEVYEIMV | QCWNSEPEKR | PSFYHLSEIV | 
    1000:
    ENLLPGQYKK | SYEKIHLDFL | KSDHPAVARM | RVDSDNAYIG | VTYKNEEDKL | 
    1050:
    KDWEGGLDEQ | RLSADSGYII | PLPDIDPVPE | EEDLGKRNRH | SSQTSEESAI | 
    1089:
    ETGSSSSTFI | KREDETIEDI | DMMDDIGIDS | SDLVEDSFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse PDGF-R-alpha
    Cat.:
    E0111h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse PDGF-R-alpha
    Cat.:
    E0111c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse PDGF-R-alpha
    Cat.:
    E0111m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Mouse PDGF-R-alpha
    Cat.:
    E0111r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse PDGF-R-alpha
    Cat.:
    U0111c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse PDGF-R-alpha
    Cat.:
    U0111r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PDGF-R-alpha
    Cat.:
    U0111m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse PDGF-R-alpha
    Cat.:
    U0111h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Mouse PDGF-R-alpha
    Cat.:
    P0111Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PDGF-R-alpha
    Cat.:
    P0111Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PDGF-R-alpha
    Cat.:
    P0111Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse PDGF-R-alpha
    Monoclonal Antibody for Mouse PDGF-R-alpha
    Monoclonal Antibody for Mouse PDGF-R-alpha
    Monoclonal Antibody for Mouse PDGF-R-alpha
    Monoclonal Antibody for Mouse PDGF-R-alpha
    Protein for Mouse PDGF-R-alpha
    Protein for Mouse PDGF-R-alpha
    Protein for Mouse PDGF-R-alpha
    Protein for Mouse PDGF-R-alpha

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene."
      Stiles C.D. , Wang C.
      Mol. Cell. Biol.10:6781-6784(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Mouse platelet-derived growth factor alpha receptor: sequence, tissue-specific expression and correlation with metastatic phenotype."
      Do M.S. , Fitzer-Attas C. , Gubbay J. , Greenfeld L. , Feldman M. , Eisenbach L.
      Oncogene7:1567-1575(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Colon.
      tissue: Embryonic head.
      tissue: Placenta.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      "The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites."
      Soriano P.
      Development124:2691-2700(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    6. 6.
      "Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis."
      Karlsson L. , Lindahl P. , Heath J.K. , Betsholtz C.
      Development127:3457-3466(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
    7. 7.
      "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization."
      Hooshmand-Rad R. , Lu L. , Heldin C.-H. , Claesson-Welsh L. , Welsh M.
      Exp. Cell Res.257:245-254(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
    8. 8.
      "Obstructive uropathy in mice and humans: potential role for PDGF-D in the progression of tubulointerstitial injury."
      Taneda S. , Hudkins K.L. , Topouzis S. , Gilbertson D.G. , Ophascharoensuk V. , Truong L. , Johnson R.J. , Alpers C.E.
      J. Am. Soc. Nephrol.14:2544-2555(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    9. 9.
      "Insight into the physiological functions of PDGF through genetic studies in mice."
      Betsholtz C.
      Cytokine Growth Factor Rev.15:215-228(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION;DISRUPTION PHENOTYPE
    10. 10.
      "Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cells."
      Wu E. , Palmer N. , Tian Z. , Moseman A.P. , Galdzicki M. , Wang X. , Berger B. , Zhang H. , Kohane I.S.
      PLoS ONE3:E3794-E3794(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    11. 11.
      "Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts."
      Schneider L. , Cammer M. , Lehman J. , Nielsen S.K. , Guerra C.F. , Veland I.R. , Stock C. , Hoffmann E.K. , Yoder B.K. , Schwab A. , Satir P. , Christensen S.T.
      Cell. Physiol. Biochem.25:279-292(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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