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Index > Protein center > Jup(Gene name) > Rat
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  • Jup (Gene name),
  • Junction plakoglobin (Protein name ),  PLAK_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Jup;
    Protein name:
    Junction plakoglobin;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer. Component of an E-cadherin/ catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ.
    Function:
    Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
    Subcellular Location:
    Cell junction adherens junction Cell junction desmosome Cytoplasm cytoskeleton Membrane Peripheral membrane protein Cytoplasmic in a soluble and membrane-associated form.
    Protein Attributes:
    Sequence length:
    745
    Sequence:
    50:
    MEVMNLIEQP | IKVTEWQQTY | TYDSGIHSGV | NTCVPSVSSK | GLLDEDDTCG | 
    100:
    RQYTLKKTTT | YTQGVPQSQG | DLEYQMSTTA | RAKRVREAMC | PGVSGEDSSL | 
    150:
    LLATQVEGQT | TNLQRLAEPS | QLLKSAIVHL | INYQDDAELA | TRALPELTKL | 
    200:
    LNDEDPVVVT | KAAMIVNQLS | KKEASRRALM | GSPQLVAAVV | RTMQNTSDLD | 
    250:
    TARCTTSILH | NLSHHREGLL | AIFKSGGIPA | LVRMLSSPVE | SVLFYAITTL | 
    300:
    HNLLLYQEGA | KMAVRLADGL | QKMVPLLNKN | NPKFLAITTD | CLQLLAYGNQ | 
    350:
    ESKLIILANG | GPQGLVQIMR | NYSYEKLLWT | TSRVLKVLSV | CPSNKPAIVE | 
    400:
    AGGMQALGKH | LTSNSPRLVQ | NCLWTLRNLS | DVATKQEGLE | NVLKILVNQL | 
    450:
    SVDDVNVLTC | ATGTLSNLTC | NNSKNKTLVT | QNSGVEALIH | AILRAGDKDD | 
    500:
    ITEPAVCALR | HLTSRHPEAE | MAQNSVRLNY | GIPAIVKLLN | QPNQWPLVKA | 
    550:
    TIGLIRNLAL | CPANHAPLQE | AAVIPRLVQL | LVKAHQDAQR | HVAAGTQQPY | 
    600:
    TDGVRMEEIV | EGCTGALHIL | ARDPMNRMEI | FRLNTIPLFV | QLLYSSVENI | 
    650:
    QRVAAGVLCE | LAQDKEAADA | IDAEGASAPL | MELLHSRNEG | TATYAAAVLF | 
    700:
    RISEDKNPDY | RKRVSVELTN | SLFKHDPAAW | EAAQSMIPIN | EPYADDMDAT | 
    745:
    YRPMYSSDVP | LDPLDMHMDM | DGDYPMDTYS | DGLRPPYPAA | DHMLA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Junction plakoglobin
    Cat.:
    E15107h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Junction plakoglobin
    Cat.:
    U15107h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Junction plakoglobin
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Rat Junction plakoglobin
    Polyclonal Antibody for Rat Junction plakoglobin
    Polyclonal Antibody for Rat Junction plakoglobin
    Polyclonal Antibody for Rat Junction plakoglobin
    Polyclonal Antibody for Rat Junction plakoglobin
    Monoclonal Antibody for Rat Junction plakoglobin
    Monoclonal Antibody for Rat Junction plakoglobin
    Monoclonal Antibody for Rat Junction plakoglobin
    Monoclonal Antibody for Rat Junction plakoglobin
    Monoclonal Antibody for Rat Junction plakoglobin
    Protein for Rat Junction plakoglobin
    Protein for Rat Junction plakoglobin
    Protein for Rat Junction plakoglobin
    Protein for Rat Junction plakoglobin
    Protein for Rat Junction plakoglobin

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Prostate.
    2. 2.
      Lubec G. , Kang S.U. , Lubec S.
      Submitted (2007-09) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-12; 58-81; 192-203 AND 262-279;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
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