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Index > Protein center > PLA2G6(Gene name) > Human
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  • PLA2G6 (Gene name),
  • 85/88 kDa calcium-independent phospholipase A2 (Protein name ),  PLPL9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PLA2G6(PLPLA9);
    Protein name:
    85/88 kDa calcium-independent phospholipase A2(CaI-PLA2);
    Alternative:
    Intracellular membrane-associated calcium-independent phospholipase A2 beta(iPLA2-beta);Group VI phospholipase A2(GVI PLA2);Patatin-like phospholipase domain-containing protein 9(PNPLA9);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms large oligomeric 270-350 kDa structures.
    Function:
    Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
    Subcellular Location:
    Isoform SH-iPLA2 Cytoplasm
    Protein Attributes:
    Sequence length:
    806
    Sequence:
    50:
    MQFFGRLVNT | FSGVTNLFSN | PFRVKEVAVA | DYTSSDRVRE | EGQLILFQNT | 
    100:
    PNRTWDCVLV | NPRNSQSGFR | LFQLELEADA | LVNFHQYSSQ | LLPFYESSPQ | 
    150:
    VLHTEVLQHL | TDLIRNHPSW | SVAHLAVELG | IRECFHHSRI | ISCANCAENE | 
    200:
    EGCTPLHLAC | RKGDGEILVE | LVQYCHTQMD | VTDYKGETVF | HYAVQGDNSQ | 
    250:
    VLQLLGRNAV | AGLNQVNNQG | LTPLHLACQL | GKQEMVRVLL | LCNARCNIMG | 
    300:
    PNGYPIHSAM | KFSQKGCAEM | IISMDSSQIH | SKDPRYGASP | LHWAKNAEMA | 
    350:
    RMLLKRGCNV | NSTSSAGNTA | LHVAVMRNRF | DCAIVLLTHG | ANADARGEHG | 
    400:
    NTPLHLAMSK | DNVEMIKALI | VFGAEVDTPN | DFGETPTFLA | SKIGRLVTRK | 
    450:
    AILTLLRTVG | AEYCFPPIHG | VPAEQGSAAP | HHPFSLERAQ | PPPISLNNLE | 
    500:
    LQDLMHISRA | RKPAFILGSM | RDEKRTHDHL | LCLDGGGVKG | LIIIQLLIAI | 
    550:
    EKASGVATKD | LFDWVAGTST | GGILALAILH | SKSMAYMRGM | YFRMKDEVFR | 
    600:
    GSRPYESGPL | EEFLKREFGE | HTKMTDVRKP | KVMLTGTLSD | RQPAELHLFR | 
    650:
    NYDAPETVRE | PRFNQNVNLR | PPAQPSDQLV | WRAARSSGAA | PTYFRPNGRF | 
    700:
    LDGGLLANNP | TLDAMTEIHE | YNQDLIRKGQ | ANKVKKLSIV | VSLGTGRSPQ | 
    750:
    VPVTCVDVFR | PSNPWELAKT | VFGAKELGKM | VVDCCTDPDG | RAVDRARAWC | 
    800:
    EMVGIQYFRL | NPQLGTDIML | DEVSDTVLVN | ALWETEVYIY | EHREEFQKLI | 
    806:
    QLLLSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    SMR:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human CaI-PLA2
    Cat.:
    E0411r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human CaI-PLA2
    Cat.:
    E0411h
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human CaI-PLA2
    Cat.:
    E0411m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CaI-PLA2
    Cat.:
    U0411m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CaI-PLA2
    Cat.:
    U0411r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CaI-PLA2
    Cat.:
    U0411h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human CaI-PLA2
    Cat.:
    P0411Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CaI-PLA2
    Cat.:
    P0411Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CaI-PLA2
    Cat.:
    P0411Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CaI-PLA2
    Monoclonal Antibody for Human CaI-PLA2
    Monoclonal Antibody for Human CaI-PLA2
    Protein for Human CaI-PLA2
    Protein for Human CaI-PLA2
    Protein for Human CaI-PLA2

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    Linearity
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    References
    1. 1.
      "Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity."
      Larsson P.K.A. , Claesson H.-E. , Kennedy B.P.
      J. Biol. Chem.273:207-214(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LH-IPLA2; ANKYRIN-IPLA2-1 AND ANKYRIN-IPLA2-2)
      tissue: B-cell.
      tissue: Testis.
    2. 2.
      "Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1."
      Ma Z. , Wang X. , Nowatzke W. , Ramanadham S. , Turk J.
      J. Biol. Chem.274:9607-9616(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS LH-IPLA2 AND SH-IPLA2)
      tissue: Pancreatic islet.
    3. 3.
      "The human calcium-independent phospholipase A2 gene. Multiple enzymes with distinct properties from a single gene."
      Larsson Forsell P.K.A. , Kennedy B.P. , Claesson H.-E.
      Eur. J. Biochem.262:575-585(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)
      tissue: Testis.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)
    6. 6.
      NIEHS SNPs program
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-58; GLY-63; GLN-70; ASN-183 AND THR-343
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LH-IPLA2)
    8. 8.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LH-IPLA2 AND SH-IPLA2)
      tissue: Brain.
    11. 11.
      "iPLA2beta: front and center in human monocyte chemotaxis to MCP-1."
      Mishra R.S. , Carnevale K.A. , Cathcart M.K.
      J. Exp. Med.205:347-359(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CHEMOTAXIS;SUBCELLULAR LOCATION
    12. 12.
      "Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions."
      Kienesberger P.C. , Oberer M. , Lass A. , Zechner R.
      J. Lipid Res.50:S63-S68(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FAMILY
    13. 13.
      "Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome."
      Malhotra A. , Edelman-Novemsky I. , Xu Y. , Plesken H. , Ma J. , Schlame M. , Ren M.
      Proc. Natl. Acad. Sci. U.S.A.106:2337-2341(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHARMACEUTICAL USE
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NBIA2A VAL-691 DEL
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NBIA2B THR-545 AND TRP-632;VARIANTS NBIA2A GLU-310 AND VAL-691 DEL
    16. 17.
      "Characterization of PLA2G6 as a locus for dystonia-parkinsonism."
      Paisan-Ruiz C. , Bhatia K.P. , Li A. , Hernandez D. , Davis M. , Wood N.W. , Hardy J. , Houlden H. , Singleton A. , Schneider S.A.
      Ann. Neurol.65:19-23(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS PARK14 GLN-741 AND TRP-747
    17. 18.
      "Recessive truncating NALCN mutation in infantile neuroaxonal dystrophy with facial dysmorphism."
      Koeroglu C. , Seven M. , Tolun A.
      J. Med. Genet.50:515-520(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NBIA2A GLY-484 AND MET-661
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